Mass Spectrometry Methods for the Comprehensive Analysis of Emerging Functional Materials

新兴功能材料综合分析的质谱方法

• 批准号: 1808115
• 负责人: Chrys Wesdemiotis
• 金额: $ 21.9万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1808115&HistoricalAwards=false
• 关键词: Mass; Spectrometry; Methods; Comprehensive; Analysis

In this project, funded by the Chemical Measurement and Imaging Program of the Chemistry Division, Professor Chrys Wesdemiotis and his group at the University of Akron are developing new methods for the characterization of advanced materials used in mechanical, electrical, biomedical, optical, or environmental applications (such as implants, coatings, adhesives, membranes, and "smart surfaces"). The methods are based on mass spectrometry, a powerful tool for characterizing the compositions and structures. They allow accurate and sensitive analysis of the molecular structures of the synthetic macromolecular compounds comprising these materials, enabling meaningful understanding of the relationships between molecular structure and useful properties, thus facilitating the design of better, commercially viable products with desired macroscopic features. The research provides opportunities for undergraduate and graduate students (including students from underrepresented groups) to engage in modern chemical analysis and materials research, two areas with growing employment opportunities that are vital for our nation's technological advancement.A major objective of this research is to integrate mild thermal desorption/degradation with online mass spectrometry for the microstructural characterization of crosslinked polymers and materials with very high molecular weight, such as hydrogels and rubber copolymers. Relatively low temperatures are employed in order to preferentially break weak bonds or to probe sterically crowded sites, yielding oligomeric species that provide molecular connectivity detail as well as insight into crosslinkers and polymer precursors. A further objective concerns the development of surface-layer matrix assisted laser desorption ionization mass spectrometric imaging for the detection of intact molecules within the top 2 nm of synthetic material surfaces. Understanding of the surface composition and detection and characterization of unwanted defects or deliberate surface modifications is imperative for deciding a material?s suitability for a given application, since the surface is the first point of contact with the environment. The Wesdemiotis group uses multidimensional approaches (combining mass analysis, tandem mass spectrometry, and orthogonal separation by polarity and/or shape) to enable sensitive and precise analysis of the composition, structure, and architecture of synthetic macromolecular compounds that are widely employed in industrial, biomedical, and technological applications. They specifically target materials that are challenging to characterize by other methods because of their complexity, size, or topology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

项目成果

Synthesis and Characterization of Well-Defined, Tadpole-Shaped Polystyrene with a Single Atom Junction Point

• DOI: 10.1021/acs.macromol.8b01384
• 发表时间: 2018-11
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Fan Zhang;R. Quirk;Selim Gerişlioğlu;C. Wesdemiotis;Selemon Bekele;M. Tsige;Yung P. Koh;S. Simon;M. Foster

Separation, identification, and confirmation of cyclic and tadpole macromolecules via UPLC-MS/MS

通过 UPLC-MS/MS 分离、鉴定和确认环状和蝌蚪大分子

• DOI: 10.1039/d2an00208f
• 发表时间: 2022
• 期刊: The Analyst
• 作者: O'Neill, Jason M.;Mao, Jialin;Haque, Farihah M.;Barroso-Bujans, Fabienne;Grayson, Scott M.;Wesdemiotis, Chrys
• 通讯作者: Wesdemiotis, Chrys

Analysis of Thermoplastic Copolymers by Mild Thermal Degradation Coupled to Ion Mobility Mass Spectrometry

通过轻度热降解与离子淌度质谱联用分析热塑性共聚物

• DOI: 10.1002/marc.202200306
• 发表时间: 2022
• 期刊: Macromolecular Rapid Communications
• 影响因子: 4.6
• 作者: Alawani, Nadrah;Barrère‐Mangote, Caroline;Wesdemiotis, Chrys
• 通讯作者: Wesdemiotis, Chrys

Sequence isomeric giant surfactants with distinct self-assembly behaviors in solution

测序在溶液中具有独特自组装行为的异构巨型表面活性剂

• DOI: 10.1039/c8cc09207a
• 发表时间: 2019
• 期刊: Chemical Communications
• 影响因子: 4.9
• 作者: Zhang Wei;Shan Wenpeng;Zhang Shuailin;Liu Yuchu;Su Hao;Luo Jiancheng;Xia Yanfeng;Li Tao;Wesdemiotis Chrys;Liu Tianbo;Cui Honggang;Li Yiwen;Cheng Stephen Z D
• 通讯作者: Cheng Stephen Z D

Analysis of monodisperse, sequence-defined, and POSS-functionalized polyester copolymers by MALDI tandem mass spectrometry

• DOI: 10.1177/1469066719828875
• 发表时间: 2019-02-01
• 期刊: EUROPEAN JOURNAL OF MASS SPECTROMETRY
• 影响因子: 1.3
• 作者: Mao, Jialin;Zhang, Wei;Wesdemiotis, Chrys
• 通讯作者: Wesdemiotis, Chrys