The Study of Elusive Neutrals and Ion Structures by Neutralization-Reionization Mass Spectrometry Methods

中和-再电离质谱方法研究难以捉摸的中性子和离子结构

• 批准号: 9725003
• 负责人: Chrys Wesdemiotis
• 金额: $ 29.41万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-15 至 2002-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9725003&HistoricalAwards=false
• 关键词: Study; Elusive; Neutrals; Ion; Structures

The Organic and Macromolecular Chemistry Program supports the studies of Professor Chrys Wesdemiotis on the synthesis of neutral, gas-phase intermediates and their characterization by neutralization-reionization mass spectroscopy. Neutral intermediates, such as carbyne, silanone, amino acid radicals and hypermetalated species, will be prepared from the corresponding mass-selected cations or anions under conditions of endothermic neutralization at low kinetic energy. Ionization energies, proton affinities and heats of formation of these neutral intermediates will be extracted from the measured neutralization endothermicity. The different stabilities and reactivities of amino acids and peptides neutralized by proton attachment will be exploited to distinguish proton binding sites and their relative proton affinities in multi-functional biomolecules. Graduate and undergraduate students carrying out the experiments will be exposed to the construction of the neutralization-reionization mass spectrometer, its application to different chemical systems, and the analysis of the resulting data. With this New award, the Organic and Macromolecular Chemistry Program supports the research and educational activities of Professor Chrys Wesdemiotis of the University of Akron. Professor Wesdemiotis will focus his research on the synthesis and characterization of neutral intermediates that are currently thought to be short-lived intermediates in a number of chemical transformations. A number of intermediates will be prepared in the gas phase and examined under low-energy neutralization conditions in order to obtain long-sought thermodynamic parameters. The educational activities of Professor Wesdemiotis will include the training of undergraduate and graduate students in the theory and applications of neutralization-reionization mass spectroscopy.

有机和大分子化学计划支持Chrys Wesdemiotis教授对中性，气相中间体的合成及其通过中和解决定质谱的表征。 中性中间体，例如Carbyne，Silanone，氨基酸自由基和高素质的物种，将从相应的质量选择的阳离子或阴离子在低动能的吸热性中和。 这些中性中间体形成的电离能，质子亲和力和热量将从测得的中和吸热性中提取。 通过质子附着中和的氨基酸和肽的不同稳定性和反应性将被利用，以区分多功能生物分子中质子结合位点及其相对质子亲和力。 进行实验的研究生和本科生将暴露于中和解决定质谱仪的构建，其应用于不同的化学系统以及所得数据的分析。 有了这个新奖项，有机和大分子化学计划支持阿克伦大学克莱斯·韦斯迪莫蒂斯教授的研究和教育活动。 Wesdemiotis教授将把他的研究集中在中性中间体的合成和表征上，这些中性中间体目前被认为是许多化学转化中的短寿命中间体。 许多中间体将在气相中制备，并在低能中和条件下进行检查，以获得长期的热力学参数。 Wesdemiotis教授的教育活动将包括对中和解决定质谱的理论和应用的培训。