Mass Spectrometry Methods for the Characterization of Polymer Composition, Structure, and Architecture

用于表征聚合物成分、结构和结构的质谱方法

• 批准号: 1012636
• 负责人: Chrys Wesdemiotis
• 金额: $ 43.7万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012636&HistoricalAwards=false
• 关键词: Mass; Spectrometry; Methods; Characterization; Polymer

In this project, funded by the Chemical Measurement and Imaging Program of the Chemistry Division, Professor Chrys Wesdemiotis of the University of Akron and his group will develop new mass spectrometry techniques for the characterization of synthetic polymers. Tandem mass spectrometry studies involving collision-activated as well as electron-transfer dissociation will be performed on a variety of copolymers with the goal to elucidate the corresponding fragmentation pathways and evaluate the information they reveal about copolymer microstructure and sequence. A further goal is to create interfaced separation/mass spectrometry strategies for the analysis of multi-component polymer mixtures. Specifically, interactive liquid chromatography will be examined for the characterization of amphiphilic blends, and ion mobility mass spectrometry for the identification of polymer architectures, in particular the structures of supramolecular polymers. A major impetus for the planned studies is the need of precise and sensitive chemical analyses for the new macromolecular materials designed and produced for industrial, clinical, and biomedical use at the University of Akron and several corporations in Northeast Ohio. The methods developed in this project will help to engineer better, commercially viable materials for a wide variety of applications. In addition, the planned research will educate and train undergraduate, graduate and post-graduate researchers, including students from underrepresented groups, in materials research and mass spectrometry analysis, two areas of increasing employment opportunities both locally and nationally.

在化学分部的化学测量和成像计划资助的该项目中，阿克伦大学及其小组的Chrys Wesdemiotis教授将开发出新的质谱技术来表征合成聚合物。涉及碰撞激活以及电子转移分离的串联质谱研究将对各种共聚物进行，其目标是阐明相应的片段化途径并评估它们有关共聚物显微结构和序列的信息。另一个目标是创建接口分离/质谱策略，以分析多组分聚合物混合物。具体而言，将检查相互作用的液相色谱法，以表征两亲性混合物，以及用于鉴定聚合物架构的离子迁移率质谱法，尤其是超分子聚合物的结构。计划研究的主要动力是需要精确和敏感的化学分析，用于针对阿克伦大学和俄亥俄州东北部的几家公司设计和生产的新的大分子材料。该项目中开发的方法将有助于改善商业上可行的材料，以适应各种应用。此外，计划中的研究将在材料研究和质谱分析中教育和培训本科，研究生和研究生研究人员，包括来自代表性不足的团体的学生，这是本地和全国增加就业机会的两个领域。