Multidimensional Mass Spectrometry Methods for the Study of Polymer Structures, Architectures, and Interactions

用于研究聚合物结构、结构和相互作用的多维质谱方法

• 批准号: 1308307
• 负责人: Chrys Wesdemiotis
• 金额: $ 44万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1308307&HistoricalAwards=false
• 关键词: Multidimensional; Mass; Spectrometry; Methods; Study

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Chrys Wesdemiotis at the University of Akron and his group will develop multidimensional mass spectrometry methodologies for the microstructure characterization of synthetic polymers. Liquid chromatography and ion mobility separation will be combined with tandem mass spectrometry to characterize novel amphiphiles, hybrid materials, glycopolymers, biodegradable polymers, and self-assembled macromolecular systems. The ultimate goal is accurate identification of the corresponding compositions, connectivities, and architectures in order to ascertain the structural elements that control macroscopic properties and, thus, facilitate the design of advanced materials for specific tasks. Many synthetic polymers are engineered for biomedical applications. These materials are invisible to cells unless proteins attach to their surface. A second goal of this project is to probe if changes occur to proteins that interact with synthetic polymers and to quantify protein adhesion on polymers prepared for biomedical and clinical use. A third, related objective concerns the advancement of methods that probe the surface layer of synthetic polymers, so that alterations resulting from environmental factors or segregation phenomena can be determined.A major motivation for the planned studies is the need for sensitive chemical analyses of the novel materials produced for industrial and clinical purposes at the University of Akron and its industrial partners in Northeast Ohio. The methods developed in this project will help chemists to design and produce better performing and commercially important materials for a variety of uses such as medical implants, drug delivery compounds, and high performance plastics. At the same time, the planned research activities will educate and train American undergraduate, graduate, and postgraduate students, including students from underrepresented groups, in modern materials research and mass spectrometry techniques, two areas with growing employment opportunities that are vital for the nation's technological progress.

在化学测量和成像计划的支持下，阿克伦大学及其小组的Chrys Wesdemiotis教授将开发多维质谱法，用于合成聚合物的微观结构表征。 液相色谱和离子迁移率分离将与串联质谱法相结合，以表征新型的两亲物，杂种材料，糖聚合物，可生物降解的聚合物和自组装的大分子分子系统。 最终目标是准确识别相应的组合物，连接性和体系结构，以确定控制宏观特性的结构元素，从而有助于设计高级材料的特定任务。 许多合成聚合物都是针对生物医学应用设计的。 除非蛋白质附着在其表面上，否则这些材料对细胞是看不见的。 该项目的第二个目标是探测与合成聚合物相互作用的蛋白质发生的变化，并在为生物医学和临床使用准备的聚合物上量化蛋白质粘附。 第三个相关的客观涉及探测合成聚合物表面层的方法的进步，因此可以确定由环境因素或隔离现象所产生的改变。计划研究的主要动机是需要对Akron大学和北部工业派别的工业和临床目的产生的新型材料的敏感化学分析。 该项目中开发的方法将帮助化学家设计和生产更好的性能和商业上重要的材料，用于多种用途，例如医疗植入物，药物输送化合物和高性能塑料。 同时，计划的研究活动将教育和培训美国本科，研究生和研究生，包括来自代表性不足的团体的学生，现代材料研究和质谱技术，这两个领域具有越来越多的就业机会，这对于美国技术进步至关重要。