Biophotonics: Dynamical Cellular Imaging by Compact Arrays of Blue and Ultraviolet Light Emitting Diodes

生物光子学：通过蓝色和紫外发光二极管紧凑阵列进行动态细胞成像

• 批准号: 0423566
• 负责人: Arto Nurmikko
• 金额: --
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0423566&HistoricalAwards=false
• 关键词: Biophotonics; Dynamical; Cellular; Imaging; Compact

0423566NurmikkoThe proposed research will adapt and advance compact wide bandgap semiconductor light emitter devices (LEDs) at short wavelengths for their application to imaging of biological materials/systems. In particular, they will design, fabricate, and tailor blue and violet LEDs into versatile multi-element arrays that will enable the real-time imaging of the dynamics of neural cell networks via fluorescence-based excitation, on-chip. Further, ultraviolet LEDs will be employed to impart photochemical excitation of such cellular networks in a spatio-temporally selective manner for the goal of implementing an interactive interface between neural circuits and man-made optoelectronic circuits.

0423566NURMIKKOTHE提出的研究将适应和推进短波长的紧凑型宽带半导体光发射器设备（LED），以便将其应用于生物材料/系统的成像。特别是，他们将设计，制造和量身定制蓝色和紫罗兰色的LED，以通过基于荧光的激发片上的片上芯片进行多功能多元素阵列，从而实现神经细胞网络动力学的实时成像。此外，将采用紫外线LED以时空选择性的方式赋予这种细胞网络的光化学激发，以实现神经回路和人为光电电路之间的交互式接口。