RUI: Immunobiologic Studies of a Marsupial

RUI：有袋动物的免疫生物学研究

• 批准号: 9305401
• 负责人: William Stone
• 金额: $ 17万
• 依托单位: Trinity University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9305401&HistoricalAwards=false
• 关键词: RUI; Immunobiologic; Studies; Marsupial

9305401 Stone The overall objective of this project is to initiate molecular immunobiologic studies of the marsupial, Monodelphis domestica, the gray, short-tailed opossum. It has already been found that Monodelphis exhibits a typical primary immune response but an atypical secondary response. Other recent results suggest that the typical eutherian isotype switch from immunoglobulin M to Immunoglobulin G is lacking in this species. Further studies will compare Monodelphis immune responses with the mouse, a typical eutherian organism. In collaboration with other laboratories, molecular approaches will be used to study the major histocompatibility system and the T cell receptor. This research will continue to involve bright, young undergraduate students. %%% The mammalian immune system is the subject of much research in the context of human health, and much is known about immune function in the mouse and man. In contrast, very little is known about the analogous mechanisms of self recognition and defense in other animals. The overall objective of this project is to characterize the immune response of the marsupial, Monodelphis domestica, the gray, short-tailed opossum. This species is the only laboratory- adapted marsupial in America. Because marsupials separated from eutherian mammals about 130 million years ago, knowledge of their immune system may shed light on the origin of the mammalian immune system. Studies will be carried out at the cellular and biochemical levels and molecular immunobiologic studies will be initiated. With prior NSF support it has been found that Monodelphis exhibits a typical primary immune response. Further studies will compare Monodelphis immune responses with the mouse, a typical eutherian mammal. In collaboration with other laboratories molecular approaches will be used to identify MHC genes, and study the T cell receptor. This research will continue to involve bright, young undergraduate students. ***

9305401 Stone 该项目的总体目标是启动有袋动物 Monodelphis Domestica（灰色短尾负鼠）的分子免疫生物学研究。 已经发现 Monodelphis 表现出典型的初级免疫反应，但表现出非典型的次级反应。 最近的其他结果表明，该物种缺乏从免疫球蛋白 M 到免疫球蛋白 G 的典型真兽同种型转换。 进一步的研究将比较 Monodelphis 与小鼠（一种典型的真兽生物）的免疫反应。 与其他实验室合作，将使用分子方法研究主要组织相容性系统和 T 细胞受体。 这项研究将继续吸引聪明的年轻本科生。 %%% 哺乳动物的免疫系统是人类健康领域许多研究的主题，并且人们对小鼠和人类的免疫功能了解很多。 相比之下，人们对其他动物的自我识别和防御的类似机制知之甚少。 该项目的总体目标是表征有袋动物 Monodelphis Domestica（灰色短尾负鼠）的免疫反应。 该物种是美国唯一经过实验室改造的有袋动物。 由于有袋动物在大约 1.3 亿年前与真兽类哺乳动物分离，因此对其免疫系统的了解可能有助于了解哺乳动物免疫系统的起源。 将在细胞和生化水平上进行研究，并将启动分子免疫生物学研究。 在 NSF 之前的支持下，已经发现 Monodelphis 表现出典型的初级免疫反应。 进一步的研究将比较 Monodelphis 与小鼠（一种典型的真兽类哺乳动物）的免疫反应。 与其他实验室合作，分子方法将用于识别 MHC 基因，并研究 T 细胞受体。 这项研究将继续吸引聪明的年轻本科生。 ***