RUI: Developmental and Biochemical Genetic Studies of a Marsupial

RUI：有袋动物的发育和生化遗传学研究

• 批准号: 8819260
• 负责人: William Stone
• 金额: $ 24.78万
• 依托单位: Trinity University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8819260&HistoricalAwards=false
• 关键词: RUI; Developmental; Biochemical; Genetic; Studies

The major objective of this project is to study certain aspects of the development and biochemical genetics of a small marsupial (the gray short-tailed opossum) which has recently been adapted as a laboratory animal. The only fully pedigreed colony of marsupials in the United States has been established, and this provides the resource for genetic studies not otherwise possible. Because the newborn marsupial is still in a fetal stage, it is an excellent animal model for developmental studies. This research program will study the development of the immune system and the genetic control of various enzyme systems. Since marsupial and placental mammals had a common ancestor more than a million years ago, these studies should shed light on the origin and specialization of these biological systems. This research at an undergraduate institution will also involve bright undergraduate students in basic research with a view toward interesting them in careers in science.

该项目的主要目标是研究最近被改造为实验动物的小型有袋动物（灰色短尾负鼠）的发育和生化遗传学的某些方面。 美国唯一一个完全纯种的有袋动物群体已经建立，这为基因研究提供了其他方式不可能实现的资源。 由于新生有袋动物仍处于胎儿阶段，因此它是发育研究的绝佳动物模型。 该研究计划将研究免疫系统的发展和各种酶系统的遗传控制。 由于有袋动物和胎盘哺乳动物在一百万多年前拥有共同的祖先，这些研究应该揭示这些生物系统的起源和专业化。 这项在本科机构进行的研究还将让聪明的本科生参与基础研究，以期激发他们对科学职业的兴趣。