The Influence of Parental Experience On Brain Development, Behaviour, and Neuroplasticity

父母经历对大脑发育、行为和神经可塑性的影响

• 批准号: RGPIN-2016-05266
• 负责人: Gibb, Robbin
• 金额: $ 2.55万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=761410
• 关键词: Influence; Parental; Experience; Brain; Development

One of the fundamental questions in behavioural neuroscience relates to how the brain develops to produce our complex motor, social, and cognitive abilities in adulthood. It is now clear that brain development does not follow a blueprint but rather the nascent brain is sculpted by preconception, prenatal, and postnatal experiences to produce a brain that can do marvelous things. But not all brains are the same and there is remarkable variability ranging from brilliance to less than optimal outcomes.Having demonstrated that both positive and negative experiences at different times can influence brain and behavioral development, I propose to systematically examine the effects of such experiences at several developmental time points including preconception (both sires and dams), gestational (dams), perinatal, and adolescence. Short term objectives: 1. Characterization of the lifelong behavioral outcomes of offspring exposed to parental (maternal or paternal) experiences in the preconception and prenatal periods. .2. Characterization of neuroanatomical outcomes of offspring exposed to parental (maternal or paternal) experiences in the preconception and prenatal periods.3. Epigenetic analyses of offspring brain and parental germlines (sperm and ova) following parental (maternal or paternal) experiences in the preconception and prenatal periods.Long Term Objectives: 1. To study the interaction of parental experience with later offspring experience either in the perinatal period or in adolescence.2. To study how maternal and paternal experiences interact at mating or during gestation to affect brain development in offspring.3. To determine whether the negative behavioral and anatomical effects of paternal or maternal experiences such as alcohol exposure can be reversed with dietary supplements, tactile stimulation, or complex-housing in the exposed parent or whether the effects of early positive experiences can be reversed by negative experiences (stress, drugs). The overall goal of the proposed studies is to understand the “rules” that describe cerebral plasticity and its relation to behavior in development. Little is known about prenatal, including preconception experiences on brain development. Thus, our contributions have addressed the sparsely studied domains of paternal preconception experience and influence of both “positive” and “negative” prenatal (preconception and gestational) experience on offspring outcomes. By using behavioral analyses that span the developmental period to adulthood we have made new insights into how the same experience in either the prenatal or preconception period have altered impacts on offspring brain development and observed behavioral outcomes at different times during development. We seek to better understand the nature of brain development and how experiences interact to contribute to neuroplasticity and behavior.

行为神经科学关系中关于大脑如何发展以产生我们复杂的运动，社会和认知能力的基本问题之一。现在很明显，大脑发育不会遵循蓝图，而是通过先入为主，产前和产后的经历雕刻而来的大脑，以产生可以做奇妙事物的大脑。但是，并非所有的大脑都是相同的，从光彩到最佳成果的变化显着。它证明，在不同时间的正面和负面经历都会影响大脑和行为发展，我建议在几个发展时间内进行此类经验的影响，包括预先观点（爵士和大坝），gestational（gestational（dams）），以及perinational，ad的效果。短期目标：1。表征在祖国和产前期间暴露于父母（母亲或父亲）经历的后代的终身行为结果。 .2。在孕前和产前期间暴露于父母（母亲或父亲）经历的后代的神经解剖学结局的表征。3。对后代大脑和父母种系的表观遗传学分析（精子和OVA）在父母（母亲或父亲）经历后的经历和产前期间的经历。长期的目标：1。研究父母的经验与临时时期或Ademoledcente的后代经验的相互作用。2。研究在交配中或妊娠期间如何相互作用，以影响后代的大脑发育。3。为了确定父亲或饮酒等产妇经历的负面行为和解剖学作用是否可以通过饮食补充剂，触觉刺激或在暴露的父母中造成复杂性的逆转，或者是否可以通过负面体验（压力，药物）来逆转早期积极经历的影响。拟议研究的总体目标是了解描述脑可塑性及其与发展行为关系的“规则”。关于产前的知之甚少，包括关于大脑发育的先入经验。这就是我们的贡献解决了“积极”和“负面”和“消极”产前（孕前和妊娠）对后代结果的稀疏研究领域。通过使用跨越发展时期的行为分析，我们已经对产前或孕前期相同的经历如何改变了对后代大脑发育的影响，并在发育过程中不同时间观察到了行为结果。我们寻求更好地理解大脑发育的本质以及经验如何相互作用以促进神经塑性和行为。