Parental influences on recovery after early brain injury

父母对早期脑损伤后康复的影响

• 批准号: 312374-2011
• 负责人: Gibb, Robbin
• 金额: $ 1.75万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548712
• 关键词: Parental; influences; recovery; after; early

Injury to the brain is associated with a wide range of behavioural sequelae that may severely compromise the cognitive and motor capacities of the individual, leading to a significant decrement in the quality of life. Brain injury can occur at anytime during the lifespan but some stages of life pose a greater risk for damage than others. Particularly vulnerable times to experience brain injury are during certain periods of gestation and early infancy. The sensitivity of the brain to perinatal injury therefore provides an important reason for studying factors that might influence outcomes from damage to the infant brain. Furthermore, by documenting the functional deficits and resulting morphology following brain injury, we can gain insight into the nature of the normal ontogenetic processes that occur within the brain and how they support behaviour. The research proposed includes and examination of how maternal and paternal experience in the prenatal period influences the developing brain and modulates outcome after perinatal brain injury. In addition, I propose to study how environmental influences in the postnatal period can alter developmental trajectories set in the prenatal period. In summary, the focus of the proposed research is on the role of parental experience (either prenatal or preconception) on brain development and plasticity in offspring. The goal is to further understand the impact that pre-birth experience has on the wiring of the developing brain and ultimately how it recovers from a perinatal cortical injury. This research should provide a deeper understanding of how very early experiences shape brain responses to later experiences.

大脑的损伤与广泛的行为后遗症有关，这些后遗症可能严重损害了个体的认知能力和运动能力，从而导致生活质量显着下降。在生命周期内的任何时候都可能发生脑损伤，但生活的某些阶段比其他阶段造成更大的损害风险。在妊娠和婴儿期的某些时期，特别是脆弱的脑损伤时期。 因此，大脑对围产期损伤的敏感性为研究可能影响婴儿大脑损害结果的因素提供了一个重要原因。 此外，通过记录脑损伤后的功能缺陷和产生的形态，我们可以深入了解大脑内发生的正常种植过程的性质以及它们如何支持行为。 拟议的研究包括和检查产妇和父亲在产前期间如何影响发育中的大脑，并调节围产期脑损伤后的结果。 此外，我建议研究产后时期的环境影响如何改变产前期间设定的发育轨迹。 总而言之，拟议的研究的重点是父母经验（产前或先入为主）在后代的脑发育和可塑性上的作用。 目的是进一步了解出生前经验对发育中大脑的接线的影响，并最终从围产期皮层损伤中恢复过来。 这项研究应该更深入地了解早期体验如何影响大脑对以后的经历的反应。