Supercritical fluid technology for processing of lipids and bioactives

用于加工脂质和生物活性物质的超临界流体技术

• 批准号: RGPIN-2017-04384
• 负责人: Temelli, Feral
• 金额: $ 3.42万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=689583
• 关键词: Supercritical; fluid; technology; processing; lipids

The proposed research program focuses on the application of supercritical fluid technology to Canada's natural biological resources to develop novel processes and to obtain high quality value-added products. Carbon dioxide (CO2) is the supercritical fluid of choice for food applications. At temperatures and pressures above its critical point (31oC, 7.4 MPa), supercritical (SC) CO2 has properties in between those of a liquid and a gas. The use of petroleum-based organic solvents for the processing of food and natural health products is being questioned due to safety concerns. SC-CO2 extraction eliminates the use of organic solvents, leaving no solvent residue in the final product since CO2 separates as a gas upon pressure reduction. This is especially important in the rapidly growing field of natural health products/nutraceuticals since the consumers are demanding “natural” extracts. Thus, there has been a tremendous growth in the SC-CO2 extraction of health benefiting bioactive components from various plant materials at industrial scale. Development of novel applications of the SC-CO2 technology through better understanding of the fundamental principles governing this process and evaluation of the products obtained are the main goals of this research program. The use of supercritical fluids in my program involves the unit operations of extraction, fractionation, reactions, membrane separation and particle formation applied to lipids and nutraceuticals. As such, my program is unique in North America and well respected globally. The next phase of my research program will focus on enhancing our understanding of the fundamentals in terms of solubility and phase behavior of the complex mixtures of lipids and bioactives in SC-CO2. Various physical properties necessary for engineering modeling and process design such as interfacial tension and contact angle will be determined. A major focus will be column and membrane separations for the isolation of bioactives and particle formation techniques targeting micro/nano particles to design novel delivery systems for bioactives, especially for high-value functional food, nutraceutical and cosmetic applications. The bioactives of interest are omega-3 fatty acids, phytosterols, tocopherols and carotenoids, which have been demonstrated to have beneficial effects against heart disease and cancer. The proposed program will contribute to the training of highly qualified personnel in the area of food engineering, which is in high demand for value-added processing of our agricultural resources.

拟议的研究计划着重于将超临界流体技术应用于加拿大自然生物学资源，以开发新过程并获得高质量增值产品。二氧化碳（CO2）是食品应用首选的超临界流体。在其临界点（31oC，7.4 MPa）上方的温度和压力下，超临界（SC）CO2具有液体和气体之间的特性。由于安全问题，正在质疑基于石油的有机解决方案来处理食品和天然保健产品。 SC-CO2提取消除了有机溶液的使用，最终产物中没有溶液居住，因为CO2在减压后作为气体分离。由于消费者要求“天然”提取物，因此在天然保健产品/营养素的快速增长领域中尤其重要。这是，健康的SC-CO2提取的SC-CO2提取从工业规模上受益于各种植物材料的生物活性成分的巨大增长。通过更好地理解管理此过程和评估所获得产品的基本原则是该研究计划的主要目标，从而开发SC-CO2技术的新颖应用。在我的程序中，超临界流体的使用涉及提取，分级，反应，膜分离和颗粒形成的单位操作。因此，我的计划在北美和全球受人尊敬。我的研究计划的下一个阶段将集中在SC-CO2中脂质和生物活性剂的复杂混合物的溶解度和相行为方面增强我们对基本面的理解。将确定工程建模和过程设计所需的各种物理特性，例如界面张力和接触角。主要的重点将是针对生物/纳米颗粒的生物活性剂和颗粒形成技术的柱和膜分离，以设计生物活性剂的新型输送系统，尤其是用于高价值功能性食品，营养和化妆品应用。感兴趣的生物活性剂是Omega-3脂肪酸，植物固醇，生育酚和类胡萝卜素，这些脂肪酸已被证明对心脏病和癌症具有有益的作用。拟议的计划将有助于对食品工程领域的高素质人员进行培训，这是对我们农业资源的增值加工需求的高需求。