Supercritical carbon dioxide processing of lipids and nutraceuticals: Fundamentals and novel process development

脂质和营养保健品的超临界二氧化碳加工：基础知识和新工艺开发

• 批准号: 46456-2012
• 负责人: Temelli, Feral
• 金额: $ 2.99万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593168
• 关键词: Supercritical; carbon; dioxide; processing; lipids

The proposed research program focuses on the application of supercritical fluid technology to Canada's natural biological resources to develop novel processes and to obtain high quality value-added products. Carbon dioxide (CO2) is the supercritical fluid of choice for food applications. At temperatures and pressures above its critical point (31oC, 7.4 MPa), supercritical (SC) CO2 has properties in between those of a liquid and a gas. The use of petroleum-based organic solvents for the processing of food and natural health products is being questioned due to safety concerns. SC-CO2 extraction eliminates the use of organic solvents, leaving no solvent residue in the final product since CO2 separates as a gas upon pressure reduction. This is especially important in the rapidly growing field of natural health products/nutraceuticals since the consumers are demanding "natural" extracts. Thus, there has been a tremendous growth in the SC-CO2 extraction of health benefiting components from various plant materials at industrial scale. Development of novel applications of SC-CO2 technology through better understanding of the fundamental principles governing this process and evaluation of the products obtained are the main goals of this research program. The use of supercritical fluids in my program involves the unit operations of extraction, fractionation, reactions, membrane separation and particle formation applied to lipids and nutraceuticals. As such, my program is unique in North America and well respected globally. The next phase of my research program will focus on enhancing our understanding of the fundamentals in terms of solubility and phase behavior of lipids/nutraceuticals in SC-CO2. Various physical properties necessary for engineering modeling will be determined. A major focus will be membrane separations for the isolation of bioactives and particle formation techniques targeting micro/nano particles to design novel delivery systems for nutraceuticals, targeting high-value functional food, nutraceutical and cosmetic applications. The nutraceuticals of interest are omega-3 fatty acids, phytosterols, tocopherols and carotenoids, which have been demonstrated to have beneficial effects against heart disease and cancer.

拟议的研究计划着重于将超临界流体技术应用于加拿大自然生物资源来开发新型过程并获得高质量增值产品。二氧化碳（CO2）是食品应用首选的超临界流体。在其临界点（31oC，7.4 MPa）上方的温度和压力下，超临界（SC）CO2具有液体和气体之间的特性。由于安全问题，正在质疑基于石油的有机溶剂来处理食物和天然保健产品。 SC-CO2提取消除了有机溶剂的使用，最终产物中没有溶剂残留物，因为CO2在减压后作为气体分离。由于消费者要求“天然”提取物，因此在天然保健产品/营养物的快速增长领域中尤其重要。因此，在工业规模上从各种植物材料中提取健康的成分的SC-CO2提取的SC-CO2提取的巨大增长。通过更好地理解管理此过程的基本原则和对获得产品的评估是该研究计划的主要目标，从而开发SC-CO2技术的新颖应用。在我的程序中，超临界流体的使用涉及提取，分级，反应，膜分离和颗粒形成的单位操作。因此，我的计划在北美和全球受人尊敬。我的研究计划的下一个阶段将着重于增强我们在SC-CO2中脂质/营养素的溶解度和相行为方面的理解。将确定工程建模所需的各种物理特性。主要的重点是膜分离，用于靶向微/纳米颗粒的生物活性和颗粒形成技术，以设计营养素的新型递送系统，靶向高价值功能性食品，营养和化妆品应用。感兴趣的营养素是Omega-3脂肪酸，植物固醇，生育酚和类胡萝卜素，这些脂肪酸已被证明对心脏病和癌症具有有益的作用。