Supercritical carbon dioxide processing of lipids and nutraceuticals: Fundamentals and novel process development

脂质和营养保健品的超临界二氧化碳加工：基础知识和新工艺开发

• 批准号: 46456-2012
• 负责人: Temelli, Feral
• 金额: $ 2.99万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545021
• 关键词: Supercritical; carbon; dioxide; processing; lipids

The proposed research program focuses on the application of supercritical fluid technology to Canada's natural biological resources to develop novel processes and to obtain high quality value-added products. Carbon dioxide (CO2) is the supercritical fluid of choice for food applications. At temperatures and pressures above its critical point (31oC, 7.4 MPa), supercritical (SC) CO2 has properties in between those of a liquid and a gas. The use of petroleum-based organic solvents for the processing of food and natural health products is being questioned due to safety concerns. SC-CO2 extraction eliminates the use of organic solvents, leaving no solvent residue in the final product since CO2 separates as a gas upon pressure reduction. This is especially important in the rapidly growing field of natural health products/nutraceuticals since the consumers are demanding "natural" extracts. Thus, there has been a tremendous growth in the SC-CO2 extraction of health benefiting components from various plant materials at industrial scale. Development of novel applications of SC-CO2 technology through better understanding of the fundamental principles governing this process and evaluation of the products obtained are the main goals of this research program. The use of supercritical fluids in my program involves the unit operations of extraction, fractionation, reactions, membrane separation and particle formation applied to lipids and nutraceuticals. As such, my program is unique in North America and well respected globally. The next phase of my research program will focus on enhancing our understanding of the fundamentals in terms of solubility and phase behavior of lipids/nutraceuticals in SC-CO2. Various physical properties necessary for engineering modeling will be determined. A major focus will be membrane separations for the isolation of bioactives and particle formation techniques targeting micro/nano particles to design novel delivery systems for nutraceuticals, targeting high-value functional food, nutraceutical and cosmetic applications. The nutraceuticals of interest are omega-3 fatty acids, phytosterols, tocopherols and carotenoids, which have been demonstrated to have beneficial effects against heart disease and cancer.

拟议的研究计划侧重于将超临界流体技术应用于加拿大的天然生物资源，以开发新颖的工艺并获得高质量的增值产品。二氧化碳 (CO2) 是食品应用的首选超临界流体。在高于其临界点（31oC，7.4 MPa）的温度和压力下，超临界 (SC) CO2 的性质介于液体和气体之间。由于安全问题，使用石油基有机溶剂加工食品和天然保健品受到质疑。 SC-CO2 萃取无需使用有机溶剂，最终产品中不会留下任何溶剂残留，因为二氧化碳在减压时以气体形式分离。这在快速增长的天然保健品/营养保健品领域尤其重要，因为消费者需要“天然”提取物。因此，以工业规模从各种植物材料中 SC-CO2 提取有益健康成分的技术取得了巨大的发展。该研究计划的主要目标是通过更好地理解控制该过程的基本原理并评估所获得的产品来开发 SC-CO2 技术的新颖应用。在我的程序中超临界流体的使用涉及应用于脂质和营养制品的提取、分馏、反应、膜分离和颗粒形成的单元操作。因此，我的项目在北美是独一无二的，并且在全球范围内受到尊重。我的研究计划的下一阶段将重点加强我们对 SC-CO2 中脂质/营养保健品的溶解度和相行为基础知识的理解。将确定工程建模所需的各种物理特性。主要重点是用于分离生物活性物质的膜分离和针对微/纳米颗粒的颗粒形成技术，以设计新颖的营养保健品输送系统，针对高价值功能食品、营养保健品和化妆品应用。令人感兴趣的营养保健品是 omega-3 脂肪酸、植物甾醇、生育酚和类胡萝卜素，它们已被证明对预防心脏病和癌症具有有益作用。