New Methods for Asymmetric Carbon-Carbon and Carbon-Heteroatom Bond Formation

不对称碳-碳和碳-杂原子键形成的新方法

• 批准号: RGPIN-2017-05039
• 负责人: Pansare, Sunil
• 金额: $ 1.6万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632815
• 关键词: New; Methods; Asymmetric; Carbon; Heteroatom

The preparation of functionalized molecules is a central theme in organic chemistry and it is at the core of the related applied sciences such as medicine and biotechnology. A large number of biologically active organic molecules, including several medicinal agents on the market, can exist in two distinct structural forms which are non-superimposable mirror images. These are known as enantiomers. Interestingly, only one of the two possible enantiomers has the desired biological activity whereas the other is either inactive or toxic. Consequently, chemical methods for the preparation of single enantiomers are of great practical significance. The central theme of this proposal is the development of such preparative methods, and these are broadly described as methods for 'asymmetric synthesis' of organic compounds.

功能化分子的制备是有机化学的中心主题，也是医学和生物技术等相关应用科学的核心。大量的生物活性有机分子，包括市场上的几种药物，可以以两种不同的结构形式存在，这两种结构形式是不可重叠的镜像。这些被称为对映体。有趣的是，两种可能的对映体中只有一种具有所需的生物活性，而另一种则要么无活性，要么有毒。因此，化学方法制备单一对映体具有重要的实际意义。该提案的中心主题是开发此类制备方法，这些方法被广泛描述为有机化合物的“不对称合成”方法。