An assessment of market opportunities for pro-healing polymer (PHP) technology

促进愈合聚合物 (PHP) 技术的市场机会评估

• 批准号: 514303-2017
• 负责人: Santerre, Paul
• 金额: $ 1.08万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=618342
• 关键词: assessment; market; opportunities; pro; healing

The discovery/invention that is the subject of this NSERC I2I Market assessment proposal is a novel syntheticpolymer referred to as pro-healing polymer (PHP) (Univ.Toronto Disclosure No. 10002755, US provisionalapplication No.62/037,359, PCT No. PCT/CA2015/000461). PHP has the ability to reduce implant device-associatedinflammation by influencing initial adsorbed protein immediately following implantation. A majorcomplication associated with implanted devices is the formation of a fibrotic capsule as a result of a chronicinflammatory response that in many instances can impede the device's performance. This chronic inflammatoryresponse is mediated by white blood cells, particularly monocytes and derived macrophages. Following thesurgical implantation of a biomaterial, whether it is part of a biomedical device or tissue engineered product,the first biological event that occurs is the adsorption of proteins from protein-rich bodily fluids (e.g. blood,interstitial fluid). Blood monocytes and macrophages that adhere to the implants thus interact with thebiomaterial-associated adsorbed protein layer, rather than directly with the device itself. PHP is prepared usingthree monomers which can be selected to (1) provide desirable mechanical properties depending on therequirements of a proposed application, (2) exhibit biodegradable/bioresorbable or substantiallynon-degradable properties, and (3) be manufactured through both heat and light curing methods. A commonfeature of PHP is the ability to modulate the pro-inflammatory serum protein immunoglobulin G (IgG) to limitexposure of pro-inflammatory domains, thus reducing activation of adherent monocytes and macrophages thatcan damage the implant. The main aim of the proposed market assessment is to assess the market potential ofthe proposed product through assessment of market size, competitive landscape, barriers to entry, and markettrends. Analysis will also be performed to assess potential factors affecting the commercialization of thetechnology, including issues regarding product adoption by end-users, product positioning, potential

该NSERC I2I市场评估建议的发现/发明是一种新颖的合成聚合物，称为亲治疗聚合物（PHP）（UNIV.Toronto披露号10002755） /CA2015/000461）。 PHP具有通过在植入后立即影响初始吸附蛋白来减少植入物与植入物相关造成症的能力。与植入设备相关的主要复杂化是由于慢性炎症反应而形成了纤维化胶囊，在许多情况下，这种反应会阻碍设备的性能。这种慢性炎症反应是由白细胞，尤其是单核细胞和衍生巨噬细胞介导的。在生物材料的外科植入后，无论是生物医学装置还是组织工程产物的一部分，发生的第一个生物学事件是从富含蛋白质的体液（例如血液，间质流体）吸附的蛋白质。因此，粘附于植入物的血液单核细胞和巨噬细胞与生物材料相关的吸附蛋白层相互作用，而不是直接与设备本身。使用三个单体制备PHP，可以选择（1）根据提议的应用的限制提供理想的机械性能，（2）表现出可生物降解/可生物可吸收或实质性降解特性，并通过（3）通过热量和光固化来制造（3）方法。 PHP的一种常见作用是能够调节促炎血清蛋白免疫球蛋白G（IgG）对促炎性结构域的有限X，从而减少粘附的单核细胞和巨噬细胞的激活，从而损害植入物。拟议市场评估的主要目的是通过评估市场规模，竞争格局，进入障碍和市场迁移来评估拟议产品的市场潜力。还将进行分析以评估影响thetechnology商业化的潜在因素，包括有关最终用户采用产品，产品定位，潜在的问题