An assessment of market opportunities for novel antimicrobial-silica microspheres for dental materials

牙科材料用新型抗菌二氧化硅微球的市场机会评估

基本信息

批准号：
530334-2018
负责人：
Finer, Yoav
金额：
$ 1.09万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2018
资助国家：
加拿大
起止时间：
2018-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=650746
关键词：
assessment market opportunities novel antimicrobial

项目摘要

Recurrent cavities (caries) around previous dental fillings, infection of tissues around dental implants, and infection of skin wounds all present major bacterial infection-associated challenges to healthcare practitioners. These challenges could benefit from local, targeted, and long-term application of antimicrobial materials to reduce bacterial load. However, traditional antimicrobial dental fillings, implants, and wound dressings offer only short-term effects, with poor control over the amount of antimicrobial used. These materials have limited effect on diseases like recurrent dental caries that require a long lasting therapeutic effect of over 10 years.**We have developed a patent-pending novel microspheres that are loaded with antimicrobial drug for very-long-term effect, and used these spheres to make a new antimicrobial composite dental adhesive. This new adhesive, when applied at the filling-tooth interface is able to prevent recurrent cavities by killing bacteria that infiltrate this critical area, while leaving beneficial oral bacteria in the mouth unaffected. This material could also prevent infection at the dental implant-gums interface, as well as infection of skin wounds treated with a dressing containing these particles.**This NSERC I2I Market Assessment proposal will provide answers to several key questions about potential customers' perceptions of key challenges, their willingness to adopt new technology, the total market size, and perceived value of our offering. It will also identify key challenges we will need to overcome to develop these novel composite adhesives for commercialization. This information will be critical as we scale up production of our material and work to provide a commercial offering.

先前补牙材料周围的复发性蛀牙（龋齿）、牙种植体周围组织的感染以及皮肤伤口的感染都给医疗保健从业者带来了与细菌感染相关的重大挑战。这些挑战可以受益于抗菌材料的局部、有针对性和长期应用，以减少细菌负荷。然而，传统的抗菌牙科填充物、种植体和伤口敷料只能提供短期效果，并且对抗菌剂量的控制较差。这些材料对复发性龋齿等需要 10 年以上持久治疗效果的疾病效果有限。**我们开发了一种正在申请专利的新型微球，该微球装载有抗菌药物，可实现非常长期的效果，并使用这些球体可制成新型抗菌复合牙科粘合剂。这种新型粘合剂应用于填充牙齿界面时，能够杀死渗透到这一关键区域的细菌，从而防止蛀牙复发，同时保持口腔中有益的口腔细菌不受影响。这种材料还可以防止牙种植体-牙龈界面处的感染，以及用含有这些颗粒的敷料治疗的皮肤伤口的感染。**这份 NSERC I2I 市场评估提案将为有关潜在客户对产品的看法的几个关键问题提供答案。主要挑战、他们采用新技术的意愿、市场总规模以及我们产品的感知价值。它还将确定我们在开发这些新型复合粘合剂进行商业化时需要克服的关键挑战。当我们扩大材料生产并努力提供商业产品时，这些信息将至关重要。