Degradable Cardiac Patch with Immuno-modulatory function

具有免疫调节功能的可降解心脏贴片

• 批准号: 508415-2017
• 负责人: Santerre, Paul
• 金额: $ 6.64万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=621911
• 关键词: Degradable; Cardiac; Patch; Immuno; modulatory

Cardiovascular disease (CVD) is the leading cause of death in the world. Specifically, in 2012,CVD was responsible for ~17.5 million deaths globally and 62,000 deaths in Canada, costingthe Canadian economy more than $21.2 billion. Myocardial infarction or heart attacksrepresent the main cause of CVD-related deaths, resulting in irreversible heart muscledamage due to the limited regenerative capacity of the heart. This can ultimately lead to endstageheart failure, which is currently treated using heart transplantation and ventricular assistdevices (VADs). However, a shortage of donor organs as well as the high cost of VADs andtheir lack of long-term suitability for all patient types are significant limitations of thesestandard treatments. Tissue engineering and the development of cardiac tissue has becomea promising method for the repair and replacement of damaged myocardium and a means ofpreventing end-stage heart failure. In this project, and utilizing the biomaterial expertise ofSanterre lab and the cardiovascular biology expertise of the Bendeck lab (both at theUniversity of Toronto) and clinical expertise of the Dr. Epelman lab at the University Hospitalnetwork, a novel degradable polyurethane scaffold, using a biomaterial platform that has beenshown to modulate the early immune response upon implantation, will be combined withcardiac cells, which will be derived from adipose stem cells, in order to develop a functionaland vascularized cardiac patch. The properties, performance and survival of the resultingengineered patch will studied for their in vivo benefit.

心血管疾病（CVD）是世界上死亡的主要原因。具体而言，在2012年，CVD在全球造成约1750万人死亡，在加拿大造成62,000人死亡，使加拿大经济造成了超过212亿加元的损失。心肌梗死或心脏病发作表明与CVD相关的死亡的主要原因，导致心脏不可逆的心脏肌肉发达，这是由于心脏再生能力有限。这最终可能导致末端心脏失败，目前使用心脏移植和心室辅助设备（VADS）对其进行处理。但是，缺乏供体器官以及VADS的高成本和对所有患者类型的长期适合性的缺乏，这是该治疗的重大局限性。组织工程和心脏组织的发展已成为修复和替代受损的心肌的有前途的方法，以及一种预防末期心力衰竭的手段。在这个项目中，并利用了本特克实验室的生物材料专业知识和Bendeck Lab的心血管生物学专业知识（既在多伦多大学的大学）和Epelman博士实验室的临床专业知识，该大学医院网络Noge Hospital Network是一种新颖的可脱脂的多甲烷型鞋垫，使用生物材料造成生物材料造成生物材料的脱发植入后可以调节早期免疫反应的平台将与心脏细胞（将源自脂肪干细胞得出），以形成功能性和血管性心脏斑块。生成的贴片的特性，性能和生存将研究其体内益处。