Polymeric Chemical and Physical Interfaces with Blood and Musculo-skeletal tissues

聚合物与血液和肌肉骨骼组织的化学和物理界面

• 批准号: RGPIN-2018-04424
• 负责人: Santerre, Paul
• 金额: $ 9.32万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=750715
• 关键词: Polymeric; Chemical; Physical; Interfaces; Blood

Polymeric materials are made of very large molecules that self assemble into materials that have practical applications. Polymers are now commonly used in the medical field for many applications including implants for orthopaedics, dental, and vascular devices, along with many others. While for the past 40 years, these polymers have been relatively simple in nature, consisting primarily of materials made of one (i.e. polyethylene) or possibly two (i.e. polyethylene terephthalate) building blocks called monomers, our research laboratory has been exploring more complex structures with four or five completely different monomer building blocks at a time, in order to reflect some of the complex heterogeneity seen in bio-polymers (the biological molecules that carry out most of the function in our body). Upon implantation into the body, one of the first things that happens is that polymers interact with bio-polymers called proteins. These proteins are natural polymers which often contain over 10 different monomers if not more, reflecting hydrophobic, hydrophilic and ionic function. Changes in the structure of proteins are often forced upon the bio-polymers by synthetic polymers that only have one or two monomer structures. This transformation occurs in order to minimize interfacial energy between the surface and proteins. These changes often lead to negative reactions that affect biocompatibility with the cells in tissues, including the foreign body cell reactions with extracellular proteins and other cells within the body; blood clotting activity involving proteins, blood platelets and white blood cells; interfacial bonding between mineralized and extracellular matrix proteins of soft tissues; and bacterial biofilm formation at the interface of biomaterials and the latter tissues. A perspective which remains understudied is how does one use the discovered knowledge of protein interactions with surfaces as “an analytical tool” for inspiring and directing innovative new heterogeneous material chemistry, and generating tailored physical features and/or microdomain structures with morphologies that can influence the above biological processes, such as to arrive at materials which correct the aforementioned problems. It is our desire in this Discovery grant to use our knowledge gained in free radical generated polyurethane chemistry, which affords the chemical diversity of block copolymers, the ability to phase separate to form intermolecular domain structures, and the versatility in processing to readily yield physical cues that influence cell function, to now drive a program on innovative new polymeric biomaterials development. This work will one day lead to new products, conceived by evolving Canadian entrepreneurs in the field, as has been shown possible by the Santerre lab for over two decades now.

聚合物材料由非常大的分子制成，这些分子将自我组装成具有实际应用的材料。现在，聚合物在医疗领域通常用于许多应用，包括骨科，牙科和血管装置以及许多其他应用。 While for the past 40 years, these polymers have been relatively simple in nature, consisting primarily of materials made of one (i.e. polyethylene) or possible two (i.e. polyethylene terephthalate) building blocks called monomers, our research laboratory has been exploring more complex structures with four or five completely different monomer building blocks at a time, in order to reflect some of the complex heterogeneity seen in bio-polymers (the biologic在我们体内执行大部分功能的分子）。植入体内后，发生的第一件事是聚合物与称为蛋白质的生物聚合物相互作用。这些蛋白质是天然聚合物，通常含有10种不同的单体（如果不是更多），反映疏水性，亲水性和离子功能。蛋白质结构的变化通常被仅具有一个或两个单体结构的合成聚合物强迫生物聚合物。发生这种转化是为了最大程度地减少表面和蛋白质之间的界面能量。这些变化通常会导致负面反应，影响与组织中细胞的生物相容性，包括与细胞外蛋白和体内其他细胞的外国体细胞反应；涉及蛋白质，血小板和白细胞的血液凝结活性；软组织的矿化和细胞外基质蛋白之间的界面键合；在生物材料和后来的组织的界面处的细菌生物膜形成。保持理解的观点是，如何使用发现与表面的蛋白质相互作用的知识作为“分析工具”，以启发和指导创新的新型新异质材料化学，并产生量身定制的物理特征和/或微域结构，并具有形态，可以影响上述生物学过程，例如在材料上纠正近似问题，这些过程纠正了近似问题。我们的愿望是在这项发现赠款中使用我们在自由基产生的聚氨酯化学方面获得的知识，从而提供了块共聚物的化学多样性，分开相结合以形成分子间域结构的能力，以及处理中的多功能性，可以随时产生影响细胞功能的物理提示，以推动创新的新型Promerceric aporymericerialialials的开发。这项工作将有一天会导致新产品，这是由现场不断发展的加拿大企业家所构想的，桑特雷实验室已经证明了二十年来。