Novel adhesive polymeric membranes for binding degradable composite materials to bone in craniomaxillofacial repair

在颅颌面修复中将可降解复合材料粘合到骨上的新型粘合聚合物膜

• 批准号: 508529-2017
• 负责人: Santerre, Paul
• 金额: $ 13.73万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=664272
• 关键词: Novel; adhesive; polymeric; membranes; binding

Deformities of the face and skull (craniomaxillofacial, CMF) can result from high impact**trauma, congenital malformations or tumours, which can lead to both functional disabilities**and physical disfigurement. Much like a shattered vase, the fractured CMF skeleton requires**alignment and stabilization of multiple pieces for successful reconstruction. In reconstructive**surgery, generally using plates and screws, complications occur in up to half of all cases. The**investigators have been working on the development of a composite material (Bone Tape)**for skull surgical reconstruction. The concept is a strong duct tape like device that can**adhere to bone and be used to reattach fractured pieces and hold them stable until they heal.**The properties of the composite offer a unique combination of strength, versatility and ease of**use, with the flexibility of tape allowing wrapping and bonding to the complex bone contours**found in the skeleton. The composite is also made of materials that will eventually (and**safely) resorb over time after the fracture has healed, leaving only the mended bones behind.**In developing this concept with industry, the clinicians used some commercial dental bone**cements that are not degradable and may generate residual particulate which the surgeons**would prefer to be resorbed and eliminated. Hence, there is a need for the conception of a**degradable adhesive polymer with appropriate physical, surface and biocompatibility**properties that can interphase with composites. This project will ultimately provide the**foundation for such a degradable organic polymer adhesive. Our clinical and scientific team is**committed to translating the novel adhesive along with current composites into practice, in**order to improve treatment and outcomes, with less complications and better lives for those**recovering from serious CMF injuries and deformities.

面部和颅骨畸形（颅颌面，CMF）可能是由高冲击力**创伤、先天性畸形或肿瘤引起的，这可能导致功能障碍**和身体毁容。就像破碎的花瓶一样，断裂的 CMF 骨架需要**对齐和稳定多个部件才能成功重建。在通常使用钢板和螺钉的重建手术中，多达一半的病例会出现并发症。 **研究人员一直致力于开发用于颅骨外科重建的复合材料（骨带）**。这个概念是一种类似于强力管道胶带的装置，可以**粘附在骨头上，用于重新连接骨折块并保持它们稳定直至愈合。**复合材料的特性提供了强度、多功能性和易用性的独特组合* *使用时，胶带具有灵活性，可以包裹和粘合到骨骼中复杂的骨骼轮廓**。该复合材料还由在骨折愈合后随着时间的推移最终（并且**安全地）吸收的材料制成，仅留下修复的骨头。**在与工业界一起开发这一概念时，临床医生使用了一些商业牙骨**不可降解的水泥，可能会产生残留颗粒，外科医生**希望这些颗粒被再吸收和消除。因此，需要具有适当的物理、表面和生物相容性**特性且可以与复合材料相相的**可降解粘合剂聚合物。该项目最终将为这种可降解有机聚合物粘合剂提供**基础。我们的临床和科学团队**致力于将新型粘合剂与当前的复合材料一起转化为实践，**以改善治疗和结果，减少并发症，为那些从严重的 CMF 损伤和畸形中恢复的人带来更好的生活。