Lateral Hypothalamic Circuits for Feeding and Reinforcement

用于喂养和强化的外侧下丘脑回路

基本信息

批准号：
9102036
负责人：
Garret D Stuber
金额：
$ 40.78万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9102036
关键词：
Address Amygdaloid structure Behavior Behavioral Binge Eating Binge eating disorder Brain Brain region Cells Complex Consumption Data Development Diagnosis Disease Eating Eating Disorders Elements Feeding behaviors Food Future Gene Expression Glutamates Habenula Health Hypothalamic structure Indium Lateral Lesion Maps Mental Depression Mental disorders Methods Molecular Profiling Mus Neurons Obesity Opsin Organism Output Pattern Pharmaceutical Preparations Play Population Positive Reinforcements Process Proteins Psychological reinforcement Rabies virus Research Rewards Role Societies Structure Substance abuse problem Testing Therapeutic Therapeutic Intervention Ventral Tegmental Area addiction base cell type design drug of abuse feeding food consumption improved in vivo motivational processes nervous system disorder neural circuit neural patterning neuropsychiatric disorder neuropsychiatry new therapeutic target novel parabrachial nucleus research study reward processing

项目摘要

DESCRIPTION (provided by applicant): While seeking out and consuming caloric substances is essential for survival, specific brain circuits that control adaptive food seeking as well as consumption, likely become dysregulated to promote a variety of maladaptive behaviors such as addiction and binge eating. Thus, experiments designed to further understand the specific neural circuit components that control food consumption and reinforcement are of critical importance for identifying important novel targets for the development of future treatments for eating disorders. Here we propose to study the precise neural circuits of the lateral hypothalamus that regulate natural reward seeking and consumption. We plan to map the precise circuit connectivity and function between genetically defined neuronal populations of the lateral hypothalamus and afferent and efferent structures, as well to characterize the neuronal activity patterns within these circuits during reward seeking and consumption behaviors. We will also test of the necessity and sufficiency of precise circuit elements to these processes. Collectively, these experiments will elucidate the precise neural circuits that interface the laterl hypothalamus with other brain structure to orchestrate reward processing. These experiments will likely uncover many novel circuits critical for reward seeking and consumption to target for future therapeutic interventions for neuropsychiatric disorders such as addiction and depression, as well eating disorders and obesity.

描述（由申请人提供）：虽然寻找和消耗热量物质对于生存至关重要，但控制适应性食物寻找和消耗的特定大脑回路可能会失调，从而促进各种适应不良行为，例如成瘾和暴饮暴食。因此，旨在进一步了解控制食物消耗和强化的特定神经回路成分的实验对于确定开发未来饮食失调治疗的重要新靶标至关重要。在这里，我们建议研究调节自然奖励寻求和消费的外侧下丘脑的精确神经回路。我们计划绘制遗传定义的外侧下丘脑神经元群与传入和传出结构之间的精确回路连接和功能，并表征这些回路在奖励寻求和消费行为期间的神经元活动模式。我们还将测试精密电路元件对这些过程的必要性和充分性。总的来说，这些实验将阐明连接下丘脑外侧与其他大脑结构以协调奖励处理的精确神经回路。这些实验可能会发现许多对奖励寻求和消费至关重要的新回路，以针对成瘾和抑郁等神经精神疾病以及饮食失调和肥胖症等神经精神疾病的未来治疗干预。