Neural circuit elements that orchestrate cue-reward associations

协调提示-奖励关联的神经回路元件

基本信息

批准号：
9815755
负责人：
Garret D Stuber
金额：
$ 41.56万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9815755
关键词：
Architecture Axon Behavior Behavioral Brain Brain region Calcium Cell Nucleus Cells Chronic Communities Cues Data Data Set Development Diagnosis Disease Dopamine Drug Addiction Drug usage Electrophysiology (science)Elements Estradiol Female Foundations Future Genes Goals Gonadal Hormones Gonadal Steroid Hormones Hormonal Hormone Responsive Hypothalamic structure Image Incentives Individual Learning Link Medial Mediating Mental disorders Mus Neurons Neurosciences Neurotensin Output Pattern Pharmaceutical Preparations Physiological Play Population Preoptic Areas Process Property Research Resolution Rewards Role Slice Societies Specificity Stimulus Substance abuse problem Testing Time Training Ventral Tegmental Area addiction awake cell type classical conditioning conditioning drug of abuse experimental study improved in vivo incentive salience insight male motivated behavior nervous system disorder neural circuit neuropsychiatric disorder neuropsychiatry new therapeutic target optogenetics public health relevance relating to nervous system reproductive reproductive hormone response steroid hormone two-photon

项目摘要

Project Summary: The neural circuitry that encodes and mediates the establishment of cue-reward associations, an adaptive process that is essential for survival, likely becomes dysfunctional in neuropsychiatric illnesses such as drug addiction. While the full encoding of cue-reward associations require a distributed network of brain nuclei acting in concert to orchestrate behavioral output, neurons in ventral tegmental area and upstream circuits in cortex and hypothalamus are thought to play an important role in reward prediction and assigning incentive salience to environmental cues such as those that become associated with repeated drug use. In this application, we propose to state of the art deep brain two-photon imaging in awake and behaving mice to study how the encoding properties within these circuits emerge and are altered during primary reward exposure as well in associative learning. These experiments will provide important mechanistic information to explain how reward circuits encode and control the development and expression of cue-reward associations relevant to addiction.

项目概要：编码和介导提示奖励关联建立的神经回路，一种适应性对于生存至关重要的过程可能会因药物等神经精神疾病而变得功能失调瘾。虽然提示奖励关联的完整编码需要脑核的分布式网络协调一致地协调行为输出、腹侧被盖区的神经元和上游回路皮层和下丘脑被认为在奖励预测和分配激励中发挥着重要作用环境因素的显着性，例如与重复吸毒相关的因素。在这个应用中，我们建议对清醒和行为小鼠进行最先进的深部脑双光子成像研究这些电路中的编码特性如何在初级奖励暴露期间出现和改变善于联想学习。这些实验将提供重要的机制信息来解释如何奖励回路编码并控制与相关的线索奖励关联的发展和表达瘾。