ABCD-USA Consortium: Research Project

ABCD-美国联盟：研究项目

基本信息

批准号：
9150522
负责人：
MARTIN P. PAULUS
金额：
$ 222.36万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9150522
关键词：
10 year old Address Adolescence Adolescent Adolescent Development Affect Age Alcohol or Other Drugs use Alcohols American Amygdaloid structure Anterior Aversive Stimulus Base of the Brain Behavior Behavioral Behavioral Genetics Bioinformatics Biological Biological Assay Brain Brain imaging California Categories Characteristics Child Child Development Childhood Clinical assessments Communities Data Data Analyses Data Collection Development Drug Prescriptions Drug usage Ensure Environment Epidemiology Event Future Genetic Goals Health Human Illicit Drugs Individual Individual Differences Informatics Institutes Insula of Reil Interview Life Link Longitudinal Studies Machine Learning Magnetic Resonance Imaging Marijuana Mental Health Methodology Minority Monitor Negative Reinforcements Neurobiology Neurocognition Neurocognitive Neuropsychological Tests Online Systems Outcome Pain Participant Pathway interactions Patient Self-Report Pattern Pharmaceutical Preparations Phenotype Population Prevalence Preventive Intervention Procedures Process Psychopathology Quality Control Recruitment Activity Reporting Research Research Personnel Research Project Grants Risk Risk Factors Sampling Severities Site Social Functioning Standardization Substance Use Disorder Surveys Symptoms System Techniques Technology Testing Time Uncertainty Universities Youth adolescent substance use base behavioral health brain health brain research cognitive development cognitive testing cohesion cohort computerized connectome design early onset emerging adult experience forest handheld mobile device high risk illicit drug use misuse of prescription only drugs modifiable risk named group neurobiological mechanism neuroimaging novel psychological outcomes relating to nervous system response stimulus processing success temporal measurement time use trend

项目摘要

DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period associated with dramatic increases in rates of substance use. Identifying the pathways to substance use and its effects on child and adolescent development is critically important, as the effects of substance use during ongoing maturation likely have long-lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from the University of California, San Diego and Laureate Institute for Brain Research is in response to RFA-DA-15-015 as part of the ABCD-USA Consortium (5/13), to prospectively determine the neurodevelopmental and behavioral predictors and consequences of substance use on children and adolescents. A representative community sample of 1086 9-10 year olds enriched for high- risk characteristics will be recruited, contributing to the sample f 11,111 to be collected from 11 hubs across the ABCD- USA Consortium. All participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, mobile monitoring and careful assessment of substance use, environment, psychopathological symptoms, and social functioning every 2 years. Interim annual interviews and quarterly web-based assessments will provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. These Consortium-wide data obtained during the course of this project will elucidate: 1) the effects of substance use patterns on the adolescent brain; 2) the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the "gateway interactions" between use of different substances. This hub's Research Project focuses on mechanisms of substance use disorder, special populations with high use prevalence, and the use of drugs other than marijuana. (1) We will determine whether individual differences in neural processing of antireward (i.e., negative reinforcement mechanisms) in amygdala, insula, and anterior cingulate are associated with increased negative emotionality and pain, predict initiation of use and problem use, and are in turn further dysregulated by substance use. (2) We will determine whether protective environment factors and ethnic identification in minority youth are linked to healthier antireward processing and better substance use outcomes. (3) We will determine whether antireward neural processing predicts increased use of illicit drugs other than MJ including misuse of prescription drugs, if such use predicts subsequent exaggerated antireward processing, and if gateway interactions exist between substances. Finally, we will use machine learning approaches to develop a youth-specific risk calculator that will enable us to identify individually- based modifiable risk factor, providing brain-based targets of future novel prevention and intervention approaches.

描述（由申请人提供）：青春期是一个关键的神经发育时期，与物质使用率急剧增加相关，确定物质使用的途径及其对儿童和青少年发育的影响至关重要，因为物质使用对持续成熟的影响。可能对大脑功能和行为、健康和心理结果产生长期影响。加州大学圣地亚哥分校和获奖者大脑研究所的本研究项目网站申请是对 RFA-DA-15-015 的回应。 ABCD-USA 联盟 (5/13) 的一项研究将招募 1086 名 9-10 岁儿童的代表性社区样本，以前瞻性地确定神经发育和行为预测因子以及药物使用对儿童和青少年的影响。，从 ABCD-美国联盟的 11 个中心收集样本 f 11,111 所有参与者都将接受全面的基线评估，包括最先进的大脑评估。每两年对药物使用、环境、精神病理症状和社会功能进行成像、综合神经心理学测试、生物测定、移动监测和仔细评估，中期年度访谈和每季度基于网络的评估将提供行为、发展和生活的精确时间分辨率。在该项目过程中获得的这些联盟范围内的数据将阐明：1）物质使用模式对青少年大脑的影响；2）物质使用对行为和健康结果的影响；精神病理学和物质使用模式之间的双向关系；4）个体遗传、行为、神经生物学和环境差异对风险状况和物质使用结果的影响；5）不同物质使用之间的“网关相互作用”。 (1) 我们将确定杏仁核中反奖励（即负强化机制）的神经处理是否存在个体差异，岛叶和前扣带回与负面情绪和疼痛增加相关，预测使用的开始和问题使用，进而因物质使用而进一步失调（2）我们将确定少数族裔青少年的保护性环境因素和种族认同是否相关。 (3) 我们将确定反奖励神经处理是否会预测 MJ 以外的非法药物的使用增加，包括处方药的滥用，如果这种使用预测随后的夸大的反奖励处理，以及是否存在网关交互作用。最后，我们将使用机器学习方法开发针对青少年的风险计算器，使我们能够识别基于个人的可修改风险因素，为未来新颖的预防和干预方法提供基于大脑的目标。