NeuroMAP Phase II - Administrative Core

NeuroMAP 第二阶段 - 管理核心

• 批准号: 10711135
• 负责人: MARTIN P. PAULUS
• 金额: $ 65.18万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711135
• 关键词: Address; Advisory Committees; Anxiety Disorders; Applications Grants; Award; Behavior; Biological; Brain; Budgets; Clinical assessments; Communities; Competence; Complex; Consultations; Data; Data Analyses; Development; Eligibility Determination; Ensure; Environment; Evaluation; Faculty; Feedback; Fostering; Foundations; Funding; Future; Genetic; Grant; Human Resources; Infrastructure; Institution; Institutional Review Boards; Laboratories; Leadership; Measures; Mental Health; Mentors; Mentorship; Modeling; Mood Disorders; Neurosciences; Oklahoma; Outcome; Persons; Phase; Pilot Projects; Process; Program Development; Questionnaires; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Robin bird; Standardization; Structure; Suggestion; Supervision; Talents; Testing; Thinking; Time Management; Training; Travel; United States National Institutes of Health; Universities; Update; Visit; Work; base; blood-based biomarker; career; career development; computerized data processing; effectiveness research; experience; health assessment; improved; infrastructure development; meetings; neuroimaging; operation; organizational structure; programs; recruit; response; success; supportive environment; training opportunity; virtual

PROJECT SUMMARY: Administrative Core The Administrative Core for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) CoBRE will continue to provide the following specific aims: (1) infrastructure for programmatic development and oversight; (2) an integrated training and mentoring plan for Research Project Leaders (RPLs); (3) operational support of RPL and Pilot Project Investigator (PPI) day-to-day operations; and (4) management of the Pilot Project program. The basic premise of NeuroMAP Administrative Core is that a supportive framework is necessary to create a strong, interdisciplinary, translational team of junior investigators to transition to R- level competitive researchers. NeuroMAP Phase I Administrative Core accomplishments facilitated by the strategic/scientific oversight of the Leadership Team and Advisory Committee (AC) include: (1) the foundation of a supportive base and training platform for five RPLs during Years 1-3, three RPLs during Years 4-5, and eight PPIs; (2) successful matching of External Mentors with extensive R01-level funding experience to RPLs to facilitate career development; (3) four funded R01s by NeuroMAP investigators (two RPLs and two PPIs) and 14 grant applications submitted by PPIs; (4) active integration of NeuroMAP into the local academic community via participation from Oklahoma State University, University of Oklahoma, and University of Tulsa faculty; and (5) successful recruitment of junior investigators to apply for Pilot Projects. During Phase I, the AC made various suggestions to improve NeuroMAP Phase II, which included: (1) tighter focus on grants that can be applied for based on RPL data; (2) increased statistical consultation; (3) expanding biological assessments beyond neuroimaging; (4) consideration of local mentors for RPLs and PPIs. As a result, Phase II adds the following infrastructure developments: (1) past NeuroMAP RPLs and PPIs who earned R01-level funding will now serve as Internal Mentors to current RPLs; (2) availability of Phase I NeuroMAP multilevel Core data (neuroimaging, behavior, questionnaires, clinical assessments) for new Pilot Projects, thereby facilitating hypothesis testing for future R01 grant applications; (3) successful recruitment of Dr. Wesley Thompson, a statistician with a successful track record of R01-level funding who will guide RPLs and PPIs in data analysis planning/execution; and (4) expansion of training opportunities to include research involving blood-based biomarker and genetic data processing and analysis. Accomplishing these aims of the Administrative Core will extend the critical mass of independent investigators necessary for the theme of NeuroMAP to continue to receive NIH funding and identify new treatment targets to reduce the personal, financial and societal burden of mood and anxiety disorders.

项目摘要：行政核心 基于神经科学的心理健康评估和预测的管理核心 (NeuroMAP) CoBRE将继续提供以下具体目标：（1）程序化开发的基础设施 和监督； (2) 研究项目负责人（RPL）综合培训和指导计划； (3) RPL 和试点项目调查员 (PPI) 日常运营的运营支持； (4) 管理 试点项目计划。 NeuroMAP 管理核心的基本前提是一个支持框架 有必要创建一个强大的、跨学科的、由初级研究人员组成的转化团队，以过渡到 R- 水平有竞争力的研究人员。 NeuroMAP 第一阶段行政核心成就由 对领导团队和咨询委员会 (AC) 的战略/科学监督包括：(1) 基金会 为第 1-3 年期间的 5 个 RPL、第 4-5 年期间的 3 个 RPL 提供支持基地和培训平台，以及 八个 PPI； (2) 具有丰富R01级资助经验的外部导师与RPL的成功匹配 促进职业发展； (3) NeuroMAP 研究人员资助的四个 R01（两个 RPL 和两个 PPI） 以及 PPI 提交的 14 份资助申请； (4) NeuroMAP积极融入当地学术 俄克拉荷马州立大学、俄克拉荷马大学和塔尔萨大学参与的社区 学院; (5) 成功招募初级研究员申请试点项目。在第一阶段，AC 提出了改进 NeuroMAP II 期的各种建议，其中包括：（1）更加关注能够 根据RPL数据进行申请； （二）加大统计咨询力度； (3)扩大生物学评估 超越神经影像学； (4) 考虑 RPL 和 PPI 的当地导师。因此，第二阶段增加了 以下基础设施发展：(1) 过去获得 R01 级资金的 NeuroMAP RPL 和 PPI 将 现在担任当前 RPL 的内部导师； (2) 第一期 NeuroMAP 多级核心数据的可用性 （神经影像、行为、问卷、临床评估）新的试点项目，从而促进 未来 R01 拨款申请的假设检验； (3) 成功招募Wesley Thompson博士 拥有 R01 级资助成功记录的统计学家，将指导 RPL 和 PPI 进行数据分析 规划/执行； (4) 扩大培训机会，将涉及血液的研究纳入其中 生物标志物和遗传数据处理和分析。实现行政核心的这些目标将 扩大 NeuroMAP 主题继续发展所需的独立研究者的临界数量 接受 NIH 资助并确定新的治疗目标，以减轻个人、经济和社会负担 情绪和焦虑障碍。