The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)

基于神经科学的心理健康评估和预测中心 (NEUROMAP)

基本信息

批准号：
10002251
负责人：
MARTIN P. PAULUS
金额：
$ 222.04万
依托单位：
LAUREATE INSTITUTE FOR BRAIN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10002251
关键词：
Address Affect Aftercare Anorexia Nervosa Anxiety Anxiety Disorders Award Base of the Brain Behavioral Bioinformatics Biological Biological Assay Biological Markers Biological Process Biological Psychiatry Biological Sciences Brain Brain imaging Cells Centers of Research Excellence Chicago Clinical Clinics and Hospitals Complex Core Facility Country Desire for food Development Disease Eating Disorders Electrocardiogram Electroencephalography Exposure to Extinction (Psychology)Extramural Activities Functional Magnetic Resonance Imaging Functional disorder Funding Future Goals Illinois Individual Individual Differences Inflammatory Infrastructure Inpatients Institutes Interoception Laboratories Machine Learning Magnetic Resonance Imaging Major Depressive Disorder Measures Mental Depression Mental Health Mental disorders Mentors Midwestern United States Mood Disorders Moods National Institute of Mental Health Neuraxis Neurosciences Oklahoma Outcome Outpatients Patient Recruitments Patients Peer Review Phase Pilot Projects Population Process Productivity Psychiatric therapeutic procedure Psychiatrist Psychiatry Reporting Research Research Infrastructure Research Institute Research Personnel Research Project Grants Risk Role Schizophrenia Signal Transduction Standardization Stimulus Symptoms Technical Expertise Techniques Time United States National Institutes of Health Universities base brain research career development conditioned fear data warehouse experimental study habituation health assessment health practice improved infrastructure development innovation insight motivated behavior multidisciplinary multimodality neuroimaging novel diagnostics outcome prediction predicting response predictive modeling programs recruit relating to nervous system response statistics tool

项目摘要

Project Summary Mood and anxiety disorders will account for approximately $16 x 109 lost productivity or 25% of global GDP over the next 20 years. Eating disorders are among the deadliest psychiatric diseases and Anorexia Nervosa is two to three times more deadly than schizophrenia, bipolar and major depressive disorder. The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) aims to provide a (a) scientific, (b) operational, and (c) educational infrastructure for innovative neuroscience-based research to use individual differences on several biological levels together with sophisticated statistical approaches to generate clinically meaningful predictions of risk and outcomes for mood, anxiety, and eating disorders. The Laureate Institute for Brain Research (LIBR) in Tulsa, OK, is ideally placed to provide this infrastructure because: (a) LIBR has recruited young investigators with an impressive track record of scientific productivity, (b) LIBR is situated adjacent to the Laureate Psychiatric Clinic and Hospital (LPCH), one of the Midwest's largest psychiatric facilities that provides LIBR with a pipeline for patient recruitment, and (c) LIBR closely collaborates with the University of Tulsa (TU) on computational statistics and University of Oklahoma, Tulsa (OU) on bioassay research. The Specific Aims of NeuroMAP are: (1) To provide a state of the art neuroimaging and laboratory infrastructure to conduct biological experiments with multi-level assessments using core facilities; (2) To provide a mentoring infrastructure to a group of young investigators to conduct studies that identify predictive biological markers and processes for patients with mood or anxiety disorders; (3) To create a career development infrastructure to accelerate the investigator's transition from young investigator to established investigator; (4) To build an operational infrastructure that provides the tools necessary to conduct the research projects, standardize assessments and provide a data repository for future pilot projects. NeuroMAP will consists of: (a) an Administrative Core (Paulus): to establish the infrastructure necessary to expand the research efforts of the young investigators; (b) Research Core (Bodurka, Teague, McKinney): to provide the technical expertise to utilize multi-level approaches (from cell markers to symptoms) to quantify individual differences and generate outcome predictions. The Center proposes 5 different projects: (1) Cerebellar Role In Fear Conditioning And Extinction. (Cha) Mentor: Amit Etkin, Stanford; (2) Predicting Response To Exposure Therapy In Anxiety Disorders Using Neural And Behavioral Markers Of Interoceptive Habituation (Feinstein) Mentor: Murray Stein, UCSD; (3) Interoceptive dysfunction and Appetite Dysregulation in Depression (Simmons) Mentor: Luan Phan, University of Illinois Chicago; (4) Response To Inflammatory Challenge In Major Depressive Disorder (Savitz) Mentor: Mike Irwin, UCLA; (5) Dysfunctional Interoceptive Accuracy In Anorexia Nervosa, (Khalsa) Mentor: Walt Kaye, UCSD.

项目概要情绪和焦虑障碍将造成约 16 x 109 美元的生产力损失，或全球 GDP 的 25% 未来20年。饮食失调是最致命的精神疾病和神经性厌食症之一其死亡率是精神分裂症、双相情感障碍和重度抑郁症的两到三倍。该中心基于神经科学的心理健康评估和预测 (NeuroMAP) 旨在提供 (a) 科学的、 (b) 运营和 (c) 教育基础设施，用于基于个人的创新神经科学研究几个生物学水平上的差异以及复杂的统计方法来产生临床对情绪、焦虑和饮食失调的风险和结果进行有意义的预测。获奖者研究所位于俄克拉荷马州塔尔萨的脑研究中心 (LIBR) 非常适合提供这种基础设施，因为：(a) LIBR 拥有招募了具有令人印象深刻的科学生产力记录的年轻研究人员，(b) LIBR 位于毗邻 Laureate 精神病诊所和医院 (LPCH)，这是中西部最大的精神病医院之一为 LIBR 提供患者招募渠道的设施，以及 (c) LIBR 与塔尔萨大学 (TU) 的计算统计学和俄克拉荷马大学塔尔萨分校 (OU) 的生物测定研究。 NeuroMAP 的具体目标是： (1) 提供最先进的神经影像和实验室利用核心设施进行生物实验和多层次评估的基础设施； (2) 至为一组年轻的研究人员提供指导基础设施，以开展识别预测的研究情绪或焦虑障碍患者的生物标记和过程；（三）开创事业开发基础设施，以加速研究者从年轻研究者向成熟研究者的转变研究者; (4) 建立一个可操作的基础设施，提供进行研究所需的工具项目、标准化评估并为未来试点项目提供数据存储库。 NeuroMAP 将包括： (a) 行政核心（Paulus）：建立必要的基础设施以扩大年轻研究者的研究努力； (b) 研究核心（Bodurka、Teague、McKinney）：提供利用多层次方法（从细胞标记物到症状）来量化个体的技术专业知识差异并生成结果预测。该中心提出了 5 个不同的项目： (1) 小脑角色在恐惧调节和消退中。（Cha）导师：Amit Etkin，斯坦福大学； (2) 预测暴露反应使用内感受习惯的神经和行为标记治疗焦虑症（范斯坦）导师：Murray Stein，加州大学圣地亚哥分校； (3) 抑郁症的内感受功能障碍和食欲失调（西蒙斯）导师：Luan Phan，伊利诺伊大学芝加哥分校； (4) 对炎症挑战的反应重度抑郁症（Savitz）导师：Mike Irwin，加州大学洛杉矶分校； (5) 内感受准确性功能失调神经性厌食症，（Khalsa）导师：Walt Kaye，加州大学圣地亚哥分校。