Esophageal cancer in West Kenya

西肯尼亚的食道癌

• 批准号: 9001998
• 负责人: Valerie McCormack
• 金额: $ 17.02万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-04 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9001998
• 关键词: Address; Adult; Affect; Africa; African; Age; Air Pollution; Alcohol consumption; Alcohols; Altitude; Area; Aromatic Polycyclic Hydrocarbons; Beverages; Biological Markers; Biomass; Blood; Burn injury; Cancer Etiology; Cancer Patient; Cancer Prognosis; Carcinogens; Case-Control Studies; Cereals; Cessation of life; Charcoal; Collection; DNA Repair; Deglutition Disorders; Diagnosis; Diet; Disease; Employee Strikes; Epidemiology; Esophageal Squamous Cell Carcinoma; Ethanol; Evaluation; Exposure to; Fertilizers; Funding; Health; Histology; Household; Incidence; International Agency for Research on Cancer; Intervention; Interview; Kenya; Life; Location; Malignant Neoplasms; Malignant neoplasm of esophagus; Malnutrition; Measures; Micronutrients; Milk; Minerals; Nutrient; Outcome; Participant; Patients; Plants; Play; Pollution; Population; Recruitment Activity; Research; Research Design; Risk; Risk Factors; Role; Running; Rural; Selenium; Smoking; Soil; Source; Staging; Tea; Time; Tobacco; Tobacco use; Tooth Loss; Trace Elements; Urine; Vitamins; Weight; Woman; Wood material; attenuation; base; biobank; burden of illness; cancer diagnosis; case control; design; drinking; esophageal cancer prevention; fortification; member; men; novel; outcome forecast; problem drinker; response; tobacco exposure; urinary

 DESCRIPTION (provided by applicant): Cancer of the esophagus is one of the most frequently diagnosed cancers in parts of East Africa, yet this cancer is extremely rare in West Africa. West Kenya, a region at altitude in Africa's Rift Valley, is one of East Africa's endemic areas. Typically patients are diagnosed at very late stages, and most die within months. No large-scale studies have been conducted to systematically investigate the potential causes of this cancer. Building on a successfully conducted pilot case-control study in which esophageal cancer patients are compared to non-cancer patients, we propose to continue and expand this study to investigate potential risk factors for the disease. Risk factors are obtained through interviews with participants, and include information on alcohol, tobacco, exposures to indoor pollution and hot beverage drinking. We also aim to investigate a novel hypothesis that deficiencies of some minerals in the diet may contribute to this disease in this area. The co-location of the East African esophageal cancer belt with the African rift valley suggest the dietary deficiencies may play a role as the diet is locally-source and cereal/plant based. Dietary deficiencies are difficult to evaluate in esophageal cancer patients, as patients have typically lost considerable weight by the time of diagnosis so urine and blood levels of vitamins and minerals are affected by their disease. As household members often have very similar diets, we will evaluate whether nutrient levels in such a household member can be used to approximate the patient's levels usual nutrient levels before they were ill. The factors being studied are all modifiable, thus if they are found to be causes of esophageal cancer in West Kenya, interventions could be implemented to remove exposures to carcinogens (e.g. advice on alcohol intake, particularly stronger spirits), or through fortification of fertilizers.

 描述（由申请人提供）：食道癌是东非部分地区最常见的癌症之一，但这种癌症在西非极为罕见，位于非洲大裂谷的西肯尼亚地区是其中之一。东非的流行地区的患者通常在很晚的时候就被诊断出来，大多数人在几个月内就死亡了，目前还没有进行大规模的研究来系统地调查这种癌症的潜在原因。通过将食管癌患者与非癌症患者进行比较，我们建议继续并扩大这项研究，以调查该疾病的潜在危险因素。危险因素是通过对参与者的访谈获得的，包括有关酒精、烟草、室内污染和暴露的信息。我们还旨在研究一个新的假设，即饮食中某些矿物质的缺乏可能导致该地区的这种疾病，东非食道癌带与非洲大裂谷的共处表明饮食缺乏可能是导致这种疾病的原因。玩由于饮食是本地来源且以谷物/植物为主，因此很难评估食道癌患者体重的膳食缺乏，因为患者在诊断时通常已经损失了相当多的维生素和矿物质，因此尿液和血液中的维生素和矿物质水平受到影响。由于家庭成员的饮食通常非常相似，我们将评估该家庭成员的营养水平是否可以用来近似患者患病前的营养水平。所研究的因素都是可以修改的。他们被发现在西肯尼亚，由于食道癌是导致食道癌的原因，因此可以采取干预措施来消除致癌物的暴露（例如建议摄入酒精，尤其是烈性烈酒），或通过强化肥料。

项目成果

Intra-household agreement of urinary elemental concentrations in Tanzania and Kenya: potential surrogates in case-control studies.

坦桑尼亚和肯尼亚尿元素浓度的家庭内部一致性：病例对照研究中的潜在替代品。

• 发表时间: 2019-04
• 作者: Middleton, Daniel R S;McCormack, Valerie A;Munishi, Michael O;Menya, Diana;Marriott, Andrew L;Hamilton, Elliott M;Mwasamwaja, Amos O;Mmbaga, Blandina T;Samoei, David;Osano, Odipo;Schüz, Joachim;Watts, Michael J
• 通讯作者: Watts, Michael J

Esophageal cancer male to female incidence ratios in Africa: A systematic review and meta-analysis of geographic, time and age trends.

非洲食管癌男性与女性发病率：对地理、时间和年龄趋势的系统回顾和荟萃分析。

• 发表时间: 2018-04
• 影响因子: 2.6
• 作者: Middleton, Daniel R S;Bouaoun, Liacine;Hanisch, Rachel;Bray, Freddie;Dzamalala, Charles;Chasimpha, Steady;Menya, Diana;Mbalawa, Charles Gombé;N'Da, Guy;Woldegeorgis, Mathewos A;Njie, Ramou;Koulibaly, Moussa;Buziba, Nathan;Ferro, Josefo;Nouho
• 通讯作者: Nouho

Expanding oesophageal cancer research and care in eastern Africa.

扩大东非的食道癌研究和护理。

• 发表时间: 2022-05
• 作者: African Esophageal Cancer Consortium

Traditional and commercial alcohols and esophageal cancer risk in Kenya.

肯尼亚的传统和商业酒精与食道癌风险。

• 发表时间: 2019-02-01
• 影响因子: 6.4
• 作者: Menya, Diana;Kigen, Nicholas;Oduor, Margaret;Maina, Stephen Karuru;Some, Fatma;Chumba, David;Ayuo, Paul;Osano, Odipo;Middleton, Daniel Rs;Schüz, Joachim;McCormack, Valerie A
• 通讯作者: McCormack, Valerie A

Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence.

来自八个不同发病率国家的食管鳞状细胞癌的突变特征。

• 发表时间: 2021-11
• 影响因子: 30.8
• 作者: Moody, Sarah;Senkin, Sergey;Islam, S M Ashiqul;Wang, Jingwei;Nasrollahzadeh, Dariush;Cortez Cardoso Penha, Ricardo;Fitzgerald, Stephen;Bergstrom, Erik N;Atkins, Joshua;He, Yudou;Khandekar, Azhar;Smith;Carreira, Christine;Gaborieau
• 通讯作者: Gaborieau