International Pooling Project of Mammographic Density

国际乳腺X线密度汇集项目

• 批准号: 8306431
• 负责人: Valerie McCormack
• 金额: $ 5.61万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8306431
• 关键词: Accounting; Address; Adipose tissue; Age; Alcohols; Area; Asia; Biological Markers; Breast; Central Africa; Cervix Uteri; Country; Data; Databases; Ethnic group; Exposure to; Fatty acid glycerol esters; First Births; Future; General Population; Genetic; Hawaii; Height; Hormones; Human Papillomavirus; Image; Incidence; Individual; International; International Agency for Research on Cancer; Japanese Population; Lead; Life Style; Malignant Neoplasms; Mammary Gland Parenchyma; Mammographic Density; Mammography; Maps; Measurable; Measurement; Measures; Menopausal Status; Meta-Analysis; Methods; Metric; Modality; Modeling; Monitor; Multinational Perspectives; North America; Pathway interactions; Pike fish; Population; Population Heterogeneity; Prevalence; Relative (related person); Research; Resources; Risk Assessment; Risk Factors; Role; Screening procedure; Smoking; Testing; Time; Tissues; Variant; Western World; Woman; cancer risk; comparative; imaging modality; malignant breast neoplasm; parity; trend

DESCRIPTION (provided by applicant): Women with a high percentage of fibroglandular tissue in their breast, as opposed to fatty tissue, have an increased breast cancer risk (up to 5-fold higher) in the subsequent 10 or more years. This attribute, known as mammographic density (MD), varies between women and can change within the same woman over time. Having both genetic and environmental determinants, between-country differences in MD may account for the over 6-fold international variations in breast cancer incidence rates. Only one study has investigated this to date, i.e. a US/Hawaii/Japanese comparison (Maskarinec et al. 2007). We aim to initiate a more widespread International Pooling Project of Mammographic Density to: (i) pool and obtain standardised comparable data on MD from countries spanning the breast cancer incidence range; (ii) describe international variations in overall and age-specific MD distributions and assess whether they are explained by individual-level risk factors for MD; (iii) quantify the extent to which international variations in MD correlated with corresponding breast cancer incidence rates and Pike's proposed model of breast tissue ageing; (iv) assess a range of MD metrics (absolute/relative/age-specific/cumulative); (v) continue and expand this pooled resource into the future. The International Pooling Project of Mammographic Density would be the first such initiative for MD, which could later be expanded to include new methods of MD measurement, imaging modalities and a broader range of determinants. Being led by the International Agency for Research on Cancer, we emphasize an international perspective for this marker, especially urgent as breast cancer is now the most common cancer in women in almost every country worldwide. If MD does underpin international variations in breast cancer incidence, the monitoring of MD-distributions would become an important early indicator of changes in breast cancer risk. PUBLIC HEALTH RELEVANCE: One of the strongest quantitative markers of breast cancer risk measurable on a mammogram in all women is mammographic density. The International Pooling Project on Mammographic Density will create the first standardized pooled data/imaging resource that includes women from all continents. It will be used to describe and account for international variations in mammographic density and to what extent they account for international variations in breast cancer incidence rates.

描述（由申请人提供）：与脂肪组织相比，乳房中纤维腺组织比例较高的女性在接下来的 10 年或更长时间内患乳腺癌的风险会增加（高达 5 倍）。这一属性被称为乳房 X 光密度 (MD)，在女性之间存在差异，并且同一女性可能会随着时间的推移而发生变化。由于遗传和环境决定因素，MD 的国家间差异可能是乳腺癌发病率国际差异超过 6 倍的原因。迄今为止，只有一项研究对此进行了调查，即美国/夏威夷/日本的比较（Maskarinec 等人，2007 年）。我们的目标是发起一个更广泛的国际乳房X光密度汇集项目，以：（i）汇集并获得来自乳腺癌发病范围国家的标准化可比MD数据； (ii) 描述总体和特定年龄 MD 分布的国际差异，并评估这些差异是否可以通过个人层面的 MD 风险因素来解释； (iii) 量化 MD 的国际差异与相应乳腺癌发病率和 Pike 提出的乳腺组织衰老模型的相关程度； (iv) 评估一系列 MD 指标（绝对/相对/特定年龄/累积）； (v) 未来继续并扩大这一汇集资源。国际乳房X光密度汇集项目将是第一个针对MD的此类倡议，该项目随后可能会扩大到包括新的MD测量方法、成像模式和更广泛的决定因素。在国际癌症研究机构的领导下，我们强调这一标志物的国际视角，这一点尤其紧迫，因为乳腺癌现在是全球几乎每个国家女性最常见的癌症。如果 MD 确实是乳腺癌发病率国际差异的基础，那么对 MD 分布的监测将成为乳腺癌风险变化的重要早期指标。 公共健康相关性：所有女性可通过乳房 X 光检查测量的乳腺癌风险最强的定量标志物之一是乳房 X 光密度。国际乳房X光密度汇集项目将创建第一个标准化汇集数据/成像资源，其中包括来自各大洲的女性。它将用于描述和解释乳房X线照相密度的国际差异，以及它们在多大程度上解释乳腺癌发病率的国际差异。