Immunoregulatory Networks

免疫调节网络

基本信息

批准号：
8121921
负责人：
ANDREW D ROBERTSON
金额：
$ 0.8万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8121921
关键词：
Area Asthma Autoimmune Diseases Autoimmunity Biological Process Cells Chronic Chronic Disease Collaborations Colorado Complex Crohn&apos s disease Development Disease Equilibrium Faculty Homeostasis Immune Immune response Immune system Infection Inflammatory Insulin-Dependent Diabetes Mellitus Knowledge Lead Malignant Neoplasms Mediating Mentors Methodology Modality Molecular Multiple Sclerosis Outcome Pathway interactions Patient Care Play Population Postdoctoral Fellow Regulation Regulatory T-Lymphocyte Request for Proposals Research Research Personnel Rheumatoid Arthritis Role Scientist Therapeutic Intervention Training Transcriptional Regulation Tumor Immunity Virus Diseases Work cancer therapy cell type clinical practice cytokine graduate student improved insight meetings novel novel therapeutic intervention outcome forecast pathogen prevent response symposium

项目摘要

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Immunoregulatory Networks, organized by Dario A.A. Vignali, Steven F. Ziegler and Hilde Cheroutre, which will be held in Breckenridge, Colorado from April 1 - 6, 2011. Immunoregulatory networks play a pivotal role in preventing autoimmunity and other inflammatory diseases, but also restrict anti-tumor immunity and modulate immune responses to pathogens. While regulatory T cells (Tregs) are a central component of this network, there are many other cell populations and molecular pathways that contribute to these networks. The Keystone Symposia meeting on Immunoregulatory Networks will focus on how different cellular and molecular components integrate and cooperate to prevent autoimmunity and control inflammatory immune responses. This meeting will dissect our current understanding of four key areas: transcriptional control of regulatory cell development and homeostasis, molecular control of immunoregulatory networks, mechanisms of regulatory function, and regulatory T cell plasticity. We also aim to discuss how Tregs interact with different cell types or utilize different cytokines that modulate or indirectly mediate their activity. Finally, we will assess how the advances presented can be utilized to develop novel therapies for autoimmune diseases, inflammatory diseases, chronic infections and cancers. PUBLIC HEALTH RELEVANCE: The immune system is a complex conglomeration of molecules and cells that work synchronously to fine tune responses to pathogens and modulate disease states. These fundamental biological processes are mediated by "immunoregulatory networks", an equally complex network of interactions, checks and balances. The Keystone Symposia meeting on Immunoregulatory Networks will focus on how different cellular and molecular components integrate and cooperate to prevent autoimmunity and control inflammatory immune responses.

描述（由申请人提供）：该提案请求支持由 Dario A.A. 组织的题为“免疫调节网络”的 Keystone 研讨会。 Vignali、Steven F. Ziegler 和 Hilde Cheroutre，将于 2011 年 4 月 1 日至 6 日在科罗拉多州布雷肯里奇举行。免疫调节网络在预防自身免疫和其他炎症性疾病方面发挥着关键作用，但也限制抗肿瘤免疫和调节免疫对病原体的反应。虽然调节性 T 细胞 (Treg) 是该网络的核心组成部分，但还有许多其他细胞群和分子途径对这些网络做出了贡献。免疫调节网络 Keystone 研讨会将重点讨论不同的细胞和分子成分如何整合和合作，以预防自身免疫和控制炎症免疫反应。本次会议将剖析我们目前对四个关键领域的理解：调节细胞发育和稳态的转录控制、免疫调节网络的分子控制、调节功能机制和调节性 T 细胞可塑性。我们还旨在讨论 Tregs 如何与不同的细胞类型相互作用或利用不同的细胞因子来调节或间接介导其活性。最后，我们将评估如何利用所取得的进展来开发针对自身免疫性疾病、炎症性疾病、慢性感染和癌症的新疗法。公共卫生相关性：免疫系统是分子和细胞的复杂集合体，它们同步工作以微调对病原体的反应并调节疾病状态。这些基本的生物过程是由“免疫调节网络”介导的，这是一个同样复杂的相互作用、制衡网络。免疫调节网络 Keystone 研讨会将重点讨论不同的细胞和分子成分如何整合和合作，以预防自身免疫和控制炎症免疫反应。