Inositide Signaling in Pharmacology and Disease

药理学和疾病中的肌醇信号传导

基本信息

批准号：
8061909
负责人：
ANDREW D ROBERTSON
金额：
$ 1万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8061909
关键词：
1-Phosphatidylinositol 3-Kinase Apoptosis Calcium Signaling Caliber Cell Proliferation Cell physiology Colorado Complex Development Diabetes Mellitus Discipline Disease Enzymes Eukaryotic Cell Gene Expression Health Inositol Inositol Phosphates Insulin Ion Channel Lead Lipids Malignant Neoplasms Membrane Protein Traffic Metabolic syndrome Metabolism Muscle Mutation Neuronal Dysfunction Neurons Nuclear Outcome Pathologic Processes Pathology Pathway interactions Pharmacology Phosphatidylinositols Phospholipase C Phosphotransferases Physiological Physiological Processes Physiology Play Process Proteins Regulation Request for Proposals Research Research Personnel Role Scientist Signal Pathway Signal Transduction Signaling Molecule Specificity Therapeutic Transcriptional Regulation Vesicle cell growth genetic regulatory protein human disease meetings new technology novel pathogen posters symposium trafficking

项目摘要

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Inositide Signaling in Pharmacology and Disease, organized by Marco Falasca, Nullin Divecha, John D. York and Pietro V. De Camilli, which will be held in Keystone, Colorado from February 13 - 18, 2011. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and, in doing so, control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was thought to be limited to the phospholipase C pathway; however, it is now clear that all seven phosphoinositides and more than 30 different inositol phosphates likely have specific and distinct signaling functions. Moreover, there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalization is likely to be critical to the normal functioning of cells. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated. PUBLIC HEALTH RELEVANCE: Phosphoinositides are specialized lipid molecules implicated in cancer, metabolic syndromes and muscle and neuronal pathology. The Keystone Symposia meeting on Inositide Signaling in Pharmacology and Disease will bring together key researchers in different fields with the aim of identifying novel concepts in phosphoinositide signaling that might be exploitable as pharmacological therapeutics.

描述（由申请人提供）：本提案请求支持题为药理学和疾病中的肌醇信号转导的 Keystone 研讨会，由 Marco Falasca、Nullin Divecha、John D. York 和 Pietro V. De Camilli 组织，该会议将在 Keystone 举行，科罗拉多州，2011 年 2 月 13 日至 18 日。磷酸肌醇和磷酸肌醇与关键调节因子相互作用并调节其招募和激活蛋白质，并在此过程中控制多种功能，包括细胞生长和增殖、细胞凋亡、细胞骨架动力学、胰岛素作用、囊泡运输和核功能。最初，肌醇信号传导被认为仅限于磷脂酶 C 途径；然而，现在已经清楚，所有七种磷酸肌醇和超过 30 种不同的磷酸肌醇可能具有特定且独特的信号传导功能。此外，受肌醇信号传导调节的蛋白质越来越多。这就提出了一个问题：肌醇信号传导如何控制不同的过程，同时保持信号传导的特异性。控制肌醇信号分子的水平及其亚细胞区室化可能对细胞的正常功能至关重要。这次会议将汇集来自不同背景的科学家，讨论如何利用理解肌醇信号传导来治疗复杂的人类疾病，这些疾病在肌醇信号传导失调时会表现出来。公共健康相关性：磷酸肌醇是与癌症、代谢综合征以及肌肉和神经元病理学有关的特殊脂质分子。关于药理学和疾病中的肌醇信号传导的 Keystone 研讨会将汇集不同领域的主要研究人员，目的是确定可用作药理学治疗的磷酸肌醇信号传导的新概念。