Lung Development and Repair

肺的发育和修复

• 批准号: 8053601
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.38万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8053601
• 关键词: Address; Adult; Alveolar sac; Area; Automobile Driving; Biology; Blood Vessels; Cell Lineage; Cell physiology; Cells; Clinical; Collaborations; Complex; Consensus; Data; Defect; Dependency; Development; Disease; Environmental Risk Factor; Epigenetic Process; Epithelial; Fibroblasts; Goals; Histocompatibility Testing; Immune system; Investigation; Kidney; Knowledge; Lung; Lung diseases; Lymphatic vessel; Maintenance; Mammary gland; Mediating; Mesenchymal; Molecular; Morbidity - disease rate; Morphogenesis; Natural regeneration; Neonatal; Nerve; New Mexico; Organ; Outcome; Pathway interactions; Process; Prostate; Request for Proposals; Research; Research Personnel; Respiration Disorders; Scientist; Signal Pathway; Smooth Muscle; Stem cells; System; Techniques; Tissues; Tube; Western World; Wound Healing; body system; catalyst; injury and repair; insight; lung development; meetings; mortality; neonate; posters; progenitor; repaired; response to injury; stem; stem cell biology; symposium; tissue regeneration

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Lung Development and Repair, organized by Brigid L.M. Hogan, Ross Metzger and Edward E. Morrisey, which will be held in Santa Fe, New Mexico from February 6 - 11, 2011. The lung is a complex three-dimensional organ. Its vital functions depend upon the initial establishment and maintenance of dynamic interactions between multiple tissue types. These include the highly branched system of airway tubes and terminal alveolar sacs, blood and lymphatic vessels, nerves, smooth muscle and fibroblasts, and cells of the immune system. Defects in these interactions underlie many serious respiratory disorders, both in the neonate and adult. The Keystone Symposia meeting on Lung Development and Repair will highlight recent advances in our understanding of the molecular and cellular processes driving the development of the lung and how its organization is maintained over the long term in the adult, as well as how these mechanisms are perturbed in disease. New ideas and approaches will be catalyzed by examples from other organ systems. The meeting will also address a major goal in lung biology: to identify the progenitor cells that mediate tissue regeneration and repair after damage by environmental factors or disease. PUBLIC HEALTH RELEVANCE: Pulmonary disease is one of the leading causes of morbidity and mortality in the Western world. Given its high clinical burden, additional investigation into the basic mechanisms underlying lung development, repair, and regeneration will provide important insight into neonatal and adult lung disease.

描述（由申请人提供）：本提案请求支持题为“肺发育与修复”的 Keystone 研讨会，该会议由 Brigid L.M. Hogan、Ross Metzger 和 Edward E. Morrisey 组织，将于 2 月 6 日至 2 月 6 日在新墨西哥州圣达菲举行2011 年 11 月 11 日。肺是一个复杂的三维器官。其重要功能取决于多种组织类型之间动态相互作用的初始建立和维持。这些包括气道管和终末肺泡囊、血管和淋巴管、神经、平滑肌和成纤维细胞以及免疫系统细胞的高度分支系统。这些相互作用的缺陷是新生儿和成人许多严重呼吸系统疾病的基础。关于肺发育和修复的 Keystone 研讨会将重点介绍我们对驱动肺发育的分子和细胞过程的理解的最新进展，以及成人如何长期维持其组织，以及这些机制如何受到干扰在疾病中。其他器官系统的例子将催化新的想法和方法。会议还将讨论肺生物学的一个主要目标：识别在环境因素或疾病损伤后介导组织再生和修复的祖细胞。 公共卫生相关性：肺部疾病是西方世界发病和死亡的主要原因之一。鉴于其较高的临床负担，对肺发育、修复和再生的基本机制的进一步研究将为新生儿和成人肺病提供重要的见解。