Marietta Community Actively Researching Exposure Study

玛丽埃塔社区积极开展暴露研究

• 批准号: 7848649
• 负责人: Erin N Haynes
• 金额: $ 9.72万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848649
• 关键词: Address; Adult; Affect; Age; Air; Animals; Apoptosis; Awareness; Biochemical; Biological; Biological Markers; Blood; Blood - brain barrier anatomy; Brain; Canada; Child; Child Development; Chinese People; Chronic; Code; Cognitive; Collection; Communities; Complex; Data; Development; Differentiation and Growth; Distress; Dopamine; Dose; Dust; Elements; Environmental Exposure; Environmental Health; Environmental Risk Factor; Exhibits; Exposure to; Fetus; Functional disorder; Gasoline; Hair; Health; Health Policy; Home environment; Human; Infant; Knowledge; Language Tests; Lead; Location; Long-Term Effects; Manganese; Manuals; Mathematics; Measures; Memory; Mental disorders; Metal exposure; Metals; Moods; Motor; Nail plate; Neighborhoods; Neonatal; Neuraxis; Neurodevelopmental Deficit; Neurologic; Newborn Infant; Odors; Ohio; Oral; Outcome; Parkinsonian Disorders; Pathway interactions; Performance; Personal Financing; Pilot Projects; Placenta; Policies; Pollution; Population; Predisposition; Process; Public Health; Quality Control; Rattus; Reaction Time; Recruitment Activity; Relative (related person); Research; Research Design; Research Project Grants; Resources; Risk; Rural; Sampling; Sensory; Specimen; Study Section; Symptoms; Taste Perception; Testing; Time; Tooth structure; Toxic Environmental Substances; Toxicant exposure; Training; Universities; Visual; Water; advocacy organizations; air cleaner; air monitoring; base; dissemination research; drinking water; early childhood; interest; meetings; member; neurobehavior; neurobehavioral; neurodevelopment; neuropsychiatry; neurotoxic; neurotoxicity; response; sample collection; symposium

Project Summary Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis: Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1: Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2: Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3: Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Project Narrative Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children.

项目概要 锰 (Mn) 是一种必需元素，但过量会产生神经毒性。尽管事实上 婴儿和幼儿可能比成人面临更大的锰神经毒性风险， 很少有研究评估长期接触锰对儿童的影响 发展。俄亥俄州玛丽埃塔是一个阿巴拉契亚乡村社区，一直是 50 多年来，美国和加拿大唯一的金属精炼厂。对此，社区 成立了清洁空气邻居组织 (NCA)。辛辛那提大学（UC） NCA 要求帮助他们了解其接触情况和相关的健康影响， 如果有的话。对于这个项目，玛丽埃塔社区积极开展暴露研究 （CARES），社区已经确定了研究议程，确定了研究 问题、目标、具体目的并确定项目范围内可用的资源 社区进行研究。社区成员将参与所有 研究项目的各个方面，包括环境采样、神经行为 评估、项目协调和生物标本采集。初级 本应用的目的是检查锰暴露的生物指标 儿童并了解长期接触锰对儿童的影响。加州大学将 提供环境健康研究方面的培训、监督和专业知识，以解决 以下假设：幼儿时期接触锰显着 与 7-8 岁高暴露儿童的神经发育缺陷有关 与年龄匹配的低/未暴露组相比。为了检验假设， 将实现以下社区驱动的具体目标。具体目标 1：评估 俄亥俄州玛丽埃塔市高锰暴露社区内的环境锰暴露 低锰暴露社区，剑桥，俄亥俄州。具体目标 2：评估比较 高锰暴露对儿童神经行为的影响 俄亥俄州玛丽埃塔社区和俄亥俄州剑桥的低锰暴露社区。具体的 目标 3：评估接触锰的儿童神经运动影响的比较 俄亥俄州玛丽埃塔的暴露社区和剑桥的低锰暴露社区 俄亥俄州。鉴于儿童对有毒物质暴露的独特易感性以及 有机会在长期暴露的社区中研究锰暴露，我们预计这一点 项目将对地方和国家与锰相关的公共卫生政策产生重大影响 接触。项目叙述 接触锰 (Mn) 会导致神经缺陷，这里是 全球以 MMT（一种抗爆剂）形式接触锰的潜力巨大 替代汽油中的铅。玛丽埃塔社区积极开展暴露研究 (CARES) 是一项以社区为基础的研究，旨在探讨长期健康影响 儿童接触锰。