Center for Appalachian Research in Environmental Sciences

阿巴拉契亚环境科学研究中心

• 批准号: 10610031
• 负责人: Erin N Haynes
• 金额: $ 153万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610031
• 关键词: Acceleration; Address; Affect; Air; Air Pollution; Analytical Chemistry; Appalachian Region; Arsenic; Asthma; Bioinformatics; COVID-19 surveillance; Career Mobility; Chemicals; Chromium; Chronic Disease; Chronic Obstructive Pulmonary Disease; Clinical Data; Clinical Research; Coal Mining; Colorectal Cancer; Communication; Communities; Community Outreach; Complex; Core Facility; Data Science; Dedications; Diabetes Mellitus; Discipline; Disparity; Dissemination and Implementation; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Environmental Science; Exposure to; Faculty; Fostering; Foundations; Funding; Geology; Goals; Grant; Health; Health Promotion; Health Sciences; Heart; Heart Diseases; Incidence; Infrastructure; Joints; Kentucky; Knowledge; Lead; Learning; Life Style; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Medically Underserved Area; Mentors; Mentorship; Mission; Molecular Toxicology; Natural Gas; Nickel; Obesity; Oils; Particulate; Pilot Projects; Policies; Policy Developments; Population; Procedures; Process; Public Health; Radon; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Rural Appalachia; Science; Scientist; Services; Superfund; Trace Elements; Training; Translating; Translational Research; Universities; Water; Water Pollutants; air contaminant; base; career; career development; citizen science; clinical decision-making; community engaged research; community engagement; design; disease disparity; environmental justice; equity, diversity, and inclusion; experience; exposure pathway; health assessment; health communication; health disparity; health equity; health science research; improved; innovation; interest; member; multidisciplinary; novel; organic contaminant; outreach; population health; programs; research facility; research study; responsible research conduct; rural dwellers; skills; socioeconomic disadvantage; success; synergism; tobacco smoke exposure; translational pipeline; wastewater surveillance; water quality; waterborne

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will build on our early successes, capitalize on lessons learned, and enhance our mission through a dual focus on better understanding exposure pathways and emerging environmental health threats and optimizing research translation. Our Mission is to focus on exposure pathways to better match with community concerns and to emphasize research translation. Our Values reflect strong, multidirectional community-academic partnerships, with a renewed commitment to meaningful processes, procedures, and policies that respect and promote diversity, equity, and inclusivity. Responsible conduct of research is at the foundation of our Center, appreciating the essential value of rigorous and reproducible multidisciplinary team science. Our goals are to (a) advance multidisciplinary environmental health science (EHS); (b) analyze organic contaminants and trace- elements; (c) cultivate early-stage stage and established investigators; (d) learn with and from the community, helping to inform and translate our research; and (e) build science communication skills with investigators and community partners to boost research translation. We will advance EHS across the translational spectrum around three highly integrated science themes informed by residents of rural Appalachia: 1) Health Impacts of Waterborne Contaminants (WATER); 2) Health Impacts of Indoor and Outdoor Airborne Contaminants (AIR); and 3) Emerging Environmental Health Threats (EMERGING THREATS). The central hypothesis is that exposure to established contaminants via environmental exposure pathways (e.g., water, air) and emerging environmental health threats, combined with lifestyle and societal risk factors, contributes to the disproportionately high incidence of chronic diseases and health disparities in rural Appalachia. UK-CARES draws on a strong and diverse base of EHS and community-engaged research to meet the needs of communities in rural Appalachia. We will support and mentor investigators so they can reach the translational milestones in research: (1) asking fundamental questions; (2) applying and synthesizing; (3) implementing and adjusting; (4) moving ideas to practice; and (5) creating impact. In short, UK-CARES will leverage its resources to enhance EHS at UK while also reducing health risks and disparities in rural Appalachia. An Integrated Health Sciences Facility Core, Analytical Chemistry Core for Environmental Sciences, and Community Engagement Core are integral to this effort, as these cores will provide dedicated support in analytical chemistry, trace-elements analysis, biospecimen management, and bioinformatics and bridge Center and community priorities. The Pilot Project Program supports developing research and new scientific directions, advancing the careers of scientists interested in tackling challenging environmental health questions. UK- CARES will positively impact rural Appalachia through collaborative EHS designed to generate and disseminate new knowledge and translate research to inform clinical decision making and policy development.

项目概要——总体 肯塔基大学阿巴拉契亚环境科学研究中心 (UK-CARES) 将 以我们早期的成功为基础，吸取经验教训，并通过双重关注来增强我们的使命 更好地了解暴露途径和新出现的环境健康威胁并优化研究 我们的使命是专注于曝光途径，以更好地满足社区的关注并 强调研究翻译。我们的价值观反映了强大的、多方位的社区学术伙伴关系， 重新致力于尊重和促进有意义的流程、程序和政策 多样性、公平性、包容性是我们中心的基础。 认识到严格且可重复的多学科团队科学的基本价值，我们的目标是： (a) 推进多学科环境健康科学 (EHS)； (b) 分析有机污染物并追踪 (c) 培养早期阶段和成熟的研究人员； (d) 与社区一起学习， 帮助宣传和转化我们的研究；(e) 与研究人员建立科学沟通技能； 我们将在整个转化领域推进 EHS。 围绕阿巴拉契亚农村居民告知的三个高度综合的科学主题：1）健康影响 水性污染物 (WATER)；2) 室内和室外空气污染物 (AIR) 对健康的影响； 3) 新出现的环境健康威胁（EMERGING THREATS） 中心假设是： 通过环境暴露途径（例如水、空气）接触已确定的污染物和新出现的污染物 环境健康威胁与生活方式和社会风险因素相结合，导致 阿巴拉契亚农村地区的慢性病发病率和健康差距不成比例地高。 利用强大而多样化的 EHS 基础和社区参与的研究来满足 我们将支持和指导阿巴拉契亚农村地区的社区，以便他们能够实现转化。 研究的里程碑：（1）提出基本问题；（2）应用和综合；（3）实施和综合； 调整；(4) 将想法付诸实践；(5) 创造影响力。 加强英国的 EHS，同时减少阿巴拉契亚农村地区的健康风险和差异。 健康科学设施核心、环境科学分析化学核心和社区 参与核心是这项工作不可或缺的一部分，因为这些核心将在分析方面提供专门支持 化学、微量元素分析、生物样本管理、生物信息学和桥梁中心和 试点项目计划支持发展研究和新的科学方向， 促进有兴趣解决具有挑战性的环境健康问题的科学家的职业生涯。 CARES 将通过协作 EHS 来积极影响阿巴拉契亚农村地区，旨在产生和 传播新知识并转化研究成果，为临床决策和政策制定提供信息。

项目成果

Use of Theory-Driven Report Back to Promote Lung Cancer Risk Reduction.

使用理论驱动的报告来促进降低肺癌风险。

• 发表时间: 2021-10-11
• 作者: Huntington;Rayens, Mary Kay;Wiggins, Amanda T;Butler, Karen M;Hahn, Ellen J
• 通讯作者: Hahn, Ellen J

Tris(1,3-dichloro-2-propyl) phosphate is a metabolism-disrupting chemical in male mice.

三(1,3-二氯-2-丙基)磷酸酯是一种干扰雄性小鼠新陈代谢的化学物质。

• 发表时间: 2023-02-01
• 影响因子: 3.5
• 作者: Tenlep, Sara Y Ngo;Weaver, Megan;Chen, Jianzhong;Vsevolozhskaya, Olga;Morris, Andrew J;Rashid, Cetewayo S
• 通讯作者: Rashid, Cetewayo S

Quantitative fluoride imaging of teeth using CaF emission by laser induced breakdown spectroscopy.

通过激光诱导击穿光谱法使用 CaF 发射对牙齿进行定量氟化物成像。

• 发表时间: 2023-02-08
• 影响因子: 3.4
• 作者: Martinez, Mauro;Harry, G Jean;Haynes, Erin N;Lin, Pi;Oken, Emily;Horton, Megan K;Wright, Robert O;Arora, Manish;Austin, Christine
• 通讯作者: Austin, Christine

Improving wastewater-based epidemiology performance through streamlined automation.

通过简化的自动化提高基于废水的流行病学绩效。

• 发表时间: 2023-04
• 作者: Dehghan Banadaki, Mohammad;Torabi, Soroosh;Strike, William D;Noble, Ann;Keck, James W;Berry, Scott M
• 通讯作者: Berry, Scott M

Wastewater Surveillance for SARS-CoV-2 at Long-Term Care Facilities: Mixed Methods Evaluation.

长期护理机构 SARS-CoV-2 废水监测：混合方法评估。

• 发表时间: 2023-08-29
• 作者: Keck, James W;Lindner, Jess;Liversedge, Matthew;Mijatovic, Blazan;Olsson, Cullen;Strike, William;Noble, Anni;Adatorwovor, Reuben;Lacy, Parker;Smith, Ted;Berry, Scott M
• 通讯作者: Berry, Scott M