CCSS Expansion Study Supplement

CCSS 扩展研究补充材料

基本信息

批准号：
10876211
负责人：
Gregory Armstrong
金额：
$ 96.3万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10876211
关键词：
Address Adolescent Child Childhood Childhood Cancer Survivor Study Cohort Studies Collection DNA sequencing Data Data Collection Diagnosis Digital Imaging and Communications in Medicine Disease susceptibility Eligibility Determination Future Genetic Predisposition to Disease Genotype Health Infrastructure Institution Intervention Investigation Late Effects Malignant Childhood Neoplasm Malignant Neoplasms Methodology Methods Modernization Morbidity - disease rate Outcome Paper Participant Pilot Projects Process Publications Quality of life Radiation therapy Radiometry Records Research Research Personnel Resources Risk SNP array Source Survival Rate Survivors Testing biobank childhood cancer survivor cohort computerized data processing data standards follow-up health related quality of life high risk population improved mortality multidisciplinary recruit screening guidelines survivorship

项目摘要

ABSTRACT The Childhood Cancer Survivor Study (CCSS) is a multi-institutional, multi-disciplinary collaborative research resource established to systematically evaluate long-term outcomes among children diagnosed with cancer who survived five or more years from diagnosis. With the successful recruitment and longitudinal follow-up of the cohort that includes survivors diagnosed and treated over three decades (1970-1999), the CCSS is the world’s largest established open resource for survivorship research with 38,036 eligible survivors available for investigation of late mortality, and 25,665 participants who have contributed health-related and quality of life outcomes. The resource includes comprehensive annotation of treatment exposures, ongoing longitudinal follow-up and an established biorepository from which genotype (SNP array) and DNA sequencing of 8,380 survivors are available to investigators for identification of genetic susceptibility for disease- and treatment- related late effects. Radiation therapy (RT) has substantially evolved over the past two decades since the establishment of the CCSS cohort. As opposed to previous CCSS methods which required paper copies of RT planning documents for review by the CCSS Radiation Dosimetry Center at MD Anderson, data from modern RT planning, collection and processing multi-institutional RT DICOM data spanning two decades will require a new and robust infrastructure. In this pilot study, we propose to collect and process 100 radiotherapy records from each of five representative CCSS institutions with the aim of a developing and testing a standardized data collection and processing methodology for use in a future CCSS expansion.

抽象的儿童癌症幸存者研究（CCSS）是一项多机构、多学科的合作研究建立资源系统地评估被诊断患有癌症的儿童的长期结果通过成功的招募和纵向随访，患者在诊断后存活了五年或更长时间。 CCSS 的队列包括三十年（1970-1999）期间诊断和治疗的幸存者，CCSS 是世界上最大的幸存者研究开放资源，有 38,036 名符合资格的幸存者可供使用对晚期死亡率的调查，以及对健康相关和生活质量做出贡献的 25,665 名参与者该资源包括治疗暴露的综合注释、持续的纵向研究。后续行动和已建立的生物样本库，其中包含 8,380 个样本的基因型（SNP 阵列）和 DNA 测序研究人员可以利用幸存者来鉴定疾病和治疗的遗传易感性自放射治疗（RT）以来的过去二十年里，相关的迟发效应有了很大的发展。与之前需要纸质 RT 副本的 CCSS 方法不同，CCSS 队列的建立。供 MD 安德森 CCSS 辐射剂量测定中心审查的规划文件，数据来自现代 RT 规划、收集和处理跨越二十年的多机构 RT DICOM 数据将需要在这项试点研究中，我们建议收集和处理 100 份放射治疗记录。来自五个代表性 CCSS 机构中的每一个，旨在开发和测试标准化数据用于未来 CCSS 扩展的收集和处理方法。