Cancer Control and Survivorship Program

癌症控制和生存计划

基本信息

批准号：
10582678
负责人：
Gregory Armstrong
金额：
$ 7.02万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10582678
关键词：
Address Area Behavioral Biometry Cancer Center Cancer Center Support Grant Cancer Control Cancer Survivorship Cardiopulmonary Childhood Childhood Cancer Survivor Study Childhood Cancer Treatment Chronic Disease Clinical Research Clinical Services Cognitive deficits Cohort Studies Collaborations Comprehensive Cancer Center Consensus Data Department chair Discipline Division of Cancer Epidemiology and Genetics Education Employment Endocrine Enrollment Epidemiology Fatigue Funding Future Genetic Genetic Research Goals Grant Guidelines Health Health behavior Incidence Individual Infrastructure Institution International Intervention Knowledge Late Effects Lead Leadership Life Expectancy Long-Term Survivors Malignant Childhood Neoplasm Medicine Modeling Morbidity - disease rate NCI-Designated Cancer Center Names Nature Neoplasms Neurosciences Observational Study Oncology Outcome Outcomes Research Pediatric Oncology Group Peer Review Population Postdoctoral Fellow Premature Mortality Prevalence Productivity Psychology Publications Quality of life Research Research Infrastructure Research Personnel Resource Sharing Resources Risk Risk Factors Role Saint Jude Children&apos s Research Hospital Schedule Seminal Structure Survival Rate Survivors Therapeutic Training Translating Translations Treatment Side Effects adverse outcome cancer prevention career childhood cancer survivor clinical practice cohort design efficacy evaluation experience high risk high risk population improved innovation insight inter-institutional international center member multidisciplinary next generation sequencing preservation programs psychosocial randomized, clinical trials recruit remediation reproductive screening survivorship treatment strategy working group

项目摘要

PROJECT SUMMARY/ABSTRACT—Cancer Control and Survivorship Program The overarching goal of the Cancer Control and Survivorship Program (CCSP) is to conduct highly innovative clinical, genetic, and observational research, and translate our findings into effective strategies to avert or mitigate treatment-related complications and improve the quality of life of childhood cancer survivors. Drs. Leslie L. Robison, chair of the Department of Epidemiology and Cancer Control, and Melissa Hudson, director of the Division of Cancer Survivorship, lead the Program. Their leadership roles in the CCSP's two NCI-funded cohorts, St. Jude Lifetime Cohort Study (SJLIFE) and the Childhood Cancer Survivor Study (CCSS), have facilitated seminal discoveries characterizing the magnitude and scope of morbidity of the childhood cancer experience, including the resulting burden of chronic disease and subsequent neoplasms and their contribution to premature mortality. Knowledge gained from this research has influenced the design of contemporary pediatric cancer treatment strategies and provided critical data to guide health surveillance and health preserving interventions for long-term survivors. The CCSP is structured around an extensive shared research infrastructure designed to support and enhance the research conducted by Program members. This infrastructure reflects a combination of departmental-focused resources, augmented by institutional and SJCCC-specific resources plus clinical services external to the institution. The CCSP has a total of 16 members (11 Full and 5 Associate), representing the Departments of Epidemiology & Cancer Control, Oncology, Psychology, Global Pediatric Medicine, and Pediatric Medicine. The design and conduct of innovative research is facilitated by 7 discipline-specific CCSP working groups: Neurosciences, Cardiopulmonary, Endocrine-Reproductive, Genetics, Global Outcomes, Psychosocial-Behavioral, and Epidemiology-Biostatistics, who meet on a regular schedule (bi-weekly or monthly). During the current grant period (2013-2017), CCSP members have actively engaged in intra- and inter- programmatic research collaborations. Research publications by CCSP members totaled 424 and demonstrate the highly collaborative nature of the Program with 50% reflecting an intra-programmatic and 25.9% inter- programmatic collaboration. During the current funding period, CCSP members initiated/conducted trials addressing approaches to enhance health screening for at-risk survivors, promote positive health behaviors, remediate treatment-induced cognitive deficits, and reduce fatigue, contributing a total of 2283 enrollments to interventional non-therapeutic trials. Many of these trials reflect a direct translation of observational research conducted by CCSP members. CCSP members have participated in a wide variety of multi-group collaborations (involving more than 20 NCI-designated Cancer Centers, the NCI Division of Cancer Epidemiology and Genetics, the Children's Oncology Group, and multiple international centers) to characterize treatment and genetic factors conferring high risk for specific late effects. CCSP members have a total of $4.2M in annual peer-reviewed funding, including $4.1M in NCI funding.

项目摘要/摘要——癌症控制和生存计划癌症控制和生存计划 (CCSP) 的总体目标是开展高度创新的临床、遗传和观察研究，并将我们的发现转化为有效的策略来避免或 Leslie 博士表示，可以减轻与治疗相关的并发症并提高儿童癌症幸存者的生活质量。 L. Robison，流行病学和癌症控制系主任，Melissa Hudson，主任癌症生存部门领导该计划，他们在 CCSP 的两个 NCI 资助的队列中发挥领导作用，圣裘德终身队列研究 (SJLIFE) 和儿童癌症幸存者研究 (CCSS) 促进了表征儿童癌症发病率的程度和范围的开创性发现，包括由此造成的慢性疾病和随后的肿瘤的负担及其对早产儿的影响从这项研究中获得的知识影响了当代儿科癌症的设计。治疗策略并提供关键数据来指导健康监测和健康维护干预措施 CCSP 围绕广泛的共享研究基础设施构建，旨在为长期幸存者提供帮助。支持和加强计划成员进行的研究。该基础设施体现了一种结合。以部门为中心的资源，并通过机构和 SJCCC 特定资源以及临床资源进行增强 CCSP 共有 16 名成员（11 名正式成员和 5 名准成员），代表机构的外部服务。流行病学与癌症控制系、肿瘤学系、心理学系、全球儿科医学系以及儿科医学。创新研究的设计和实施由 7 个特定学科的 CCSP 促进。工作组：神经科学、心肺、内分泌生殖、遗传学、全球成果、心理社会行为和流行病学生物统计学，定期开会（每两周一次或在当前资助期间（2013-2017），CCSP 成员积极参与内部和相互之间的活动。 CCSP 成员的研究出版物总计 424 份并展示了该计划的高度协作性质，其中 50% 反映了计划内的合作性质，25.9% 反映了计划间的合作性质在当前资助期间，CCSP 成员发起/进行了试验。采取措施加强对高危幸存者的健康筛查，促进积极的健康行为，补救治疗引起的认知缺陷，并减少疲劳，总共有 2283 人参与其中许多试验反映了观察性研究的直接转化。 CCSP 成员参与了各种多组合作。（涉及超过 20 个 NCI 指定的癌症中心、NCI 癌症流行病学和遗传学部门、儿童肿瘤学组和多个国际中心）来描述治疗和遗传因素 CCSP 成员的年度同行评审总额为 420 万美元。资金，包括 NCI 的 410 万美元资金。