A formal group theory-based model in primates for studying interactive social behavior and its dysfunction

用于研究互动社会行为及其功能障碍的基于正式群体理论的灵长类动物模型

• 批准号: 10567456
• 负责人: Ziv Williams
• 金额: $ 50.05万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10567456
• 关键词: Affect; Alcoholism; Amygdaloid structure; Animal Model; Animals; Anterior; Area; Behavior; Code; Cues; Dimensions; Disease; Dissociation; Dorsal; Ecology; Elements; Facial Expression; Functional disorder; Future; Human; Individual; Intervention; Investigation; Joints; Learning; Macaca mulatta; Major Depressive Disorder; Modeling; Neurology; Neurons; Neurosciences; Outcome; Paint; Parietal; Play; Population; Primates; Psychology; Role; Schizophrenia; Site; Social Behavior; Social Environment; Social Interaction; Specificity; Structure; Techniques; Testing; Time; Time Study; autism spectrum disorder; base; cingulate cortex; experience; experimental study; field study; gaze; member; neural; neurocognitive disorder; neuromechanism; neuroregulation; psychosocial; response; social; social cognition; social group; theories; time use

A formal group theory-based model in primates for studying interactive social behavior and its dysfunction Unlike most forms of solitary behavior that have been broadly studied through animal models, remarkably little is known about the single-neuronal or causal bases of interactive social behavior and its dysfunction. One of the major reasons for this limitation is the general lack of animal models and framework for studying the neural substrates of social behavior whereby two or more individuals interact in real-time and in a way that is amenable to neuronal analysis or perturbation techniques. This limited understanding impacts not only wide spanning fields of study such as ecology, neurology and psychology but also our ability to treat conditions such as autism-spectrum disorder in which social behavior is prominently affected. Primates are highly social animals that share many behaviors in common with humans and can serve as a potential model for understanding the basic elements that underlie interactive behavior. In this proposal, we aim to build on our team’s unique combined experience with jointly interacting primate pairs and groups, social theory, multi-site neuronal recordings and time-resolved neuromodulation techniques to begin identifying some of the basic neuronal encoding components of interactive behaviors, their representation within and across cortical populations, and their dynamic across short and long temporal scales. Using social group theory in primates together with population modeling and perturbation techniques, we will investigate core social constructs such as agency identity, group dynamics and decision strategies essential for effective social behavior. We will also test specific hypotheses on the causal contribution that distinct frontal, temporal and parietal areas play in social interaction and what exact aspects are involved. Taken together, this proposal aims to provide a formal theory- based model by which to begin investigating interactive social behavior at the single-neuronal, population and circuit-based levels. We believe that this is an essential new line of investigation and has the potential to open up a poorly explored but important field within neuroscience and from which to begin testing neuro-modulatory interventions aimed at treating psychosocial disorders.

用于研究互动社交的灵长类动物基于正式群体理论的模型 行为及其功能障碍 与通过动物模型进行广泛研究的大多数形式的孤独行为不同， 已知互动社会行为的单神经元或因果基础及其功能障碍。 造成这种限制的主要原因是普遍缺乏研究神经元的动物模型和框架。 社会行为的基础，两个或更多个人以一种实时互动的方式进行互动 这种有限的理解不仅影响广泛。 跨越生态学、神经学和心理学等研究领域，还包括我们治疗此类疾病的能力 作为自闭症谱系障碍，灵长类动物的社会行为受到显着影响。 与人类有许多共同行为的动物，可以作为潜在的模型 了解交互行为背后的基本要素 在本提案中，我们的目标是建立在我们的基础之上。 团队在灵长类动物对和群体的共同互动、社会理论、多地点方面拥有独特的综合经验 神经元记录和时间分辨神经调节技术开始识别一些基本的 交互行为的神经编码成分，它们在皮质内和皮质之间的表示 种群及其在短期和长期时间尺度上的动态。在灵长类动物中使用社会群体理论。 与人口建模和扰动技术一起，我们将研究核心社会结构，例如 作为有效社会行为所必需的机构身份、群体动态和决策策略。 测试关于不同额叶、颞叶和顶叶区域在社交中所起因果作用的具体假设 综合起来，该提案旨在提供一个正式的理论—— 基于模型开始研究单个神经元、群体和群体的互动社会行为 我们相信这是一条重要的新研究路线，并且有潜力开放。 神经科学中一个尚未探索但很重要的领域，并从该领域开始测试神经调节 这些袭击旨在治疗心理社会障碍。