Using game theory in primates to study the distributed neuronal and time-casual underpinnings of interactive social behavior

利用灵长类动物的博弈论来研究交互式社交行为的分布式神经元和时间休闲基础

• 批准号: 10197791
• 负责人: Ziv Williams
• 金额: $ 40.98万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197791
• 关键词: Address; Affect; Alcoholism; Amygdaloid structure; Animal Model; Anterior; Area; Behavior; Behavior Control; Behavior Disorders; Behavioral; Brain; Code; Computational Technique; Cues; Data; Decision Making; Deep Brain Stimulation; Disease; Dorsal; Elements; Event; Facial Expression; Foundations; Functional disorder; Future; Game Theory; Human; Impairment; Individual; Investigation; Joints; Macaca mulatta; Major Depressive Disorder; Measures; Mediating; Modeling; Neurons; Neurosciences; Outcome; Play; Population; Primates; Prisoner' s Dilemma; Rewards; Schizophrenia; Site; Social Behavior; Social Environment; Social Interaction; Structure; Sum; Techniques; Testing; Time; Time Study; Training; Validation; Work; autism spectrum disorder; base; cingulate cortex; experience; gaze; innovation; multimodality; neural circuit; neurocognitive disorder; neuroregulation; relating to nervous system; response; social; time use

Using game theory in primates to study the distributed neuronal and time- causal underpinnings of interactive social behavior Despite the importance of joint interactive social behavior and its broad involvement in many neurocognitive disorders, its single-neuronal basis, population-level encoding and time-causal underpinnings are still largely unknown. A major part of this limitation has come from our inability to ask such questions in humans. Game theory, and the iterated Prisoner's Dilemma (iPD) game in particular, provides a well-studied platform for investigating and dissociating the multi-dimensional encoding of interactive social decisions. Here, we will build on recent innovations by our group with dual interacting primate-pairs, neural population recording and deep brain stimulation (DBS) in order to systematically investigate the basic neuronal building blocks of interactive social behavior. In preliminary studies performed by our groups, we have already identified some of the key neuronal computations underlying joint social decisions. We have also established important behavioral validation measures, social context controls and cross-pair confirmations for the primate model. In this study, we will investigate, for the first time, the involvement of three principal areas theorized to comprise the “social brain” in distributively encoding and modulating distinct aspects of interactive social behavior. These areas include the dorsal anterior cingulate cortex, anterior intraparietal area and the basolateral amygdala. We will specifically examine the single-neuronal and population encoding of self vs. other agency, joint interaction, social context and agent identity. We will test how these representations are modulated by social cues and examine the targeted modulation of the different areas by both standard and event-triggered DBS. Overall, this proposal represents a completely new line of investigation that is not possible to conduct in humans, and opens up an important unexplored area in neuroscience. The proposed set of studies will provide the first comprehensive roadmap of the primate “social brain” at the neuronal and population level, and offer critical guidance for future targeted treatments of social behavioral disorders.

使用灵长类动物的博弈论来研究分布式神经和时间- 互动社会行为的因果基础 尽管联合互动社交行为很重要并且广泛参与许多领域 神经认知障碍，其单神经元基础，群体水平编码和时间因果关系 这种限制的主要原因仍然是未知的。 在人类博弈论和迭代囚徒困境（iPD）博弈中提出这样的问题。 特别是，提供了一个经过充分研究的平台，用于调查和分离多维 在这里，我们将利用我们团队最近的创新成果对交互式社会决策进行编码。 相互作用的灵长类动物对、神经群体记录和深部脑刺激 (DBS) 彻底研究互动社会行为的基本神经构建模块。 我们小组进行的初步研究，我们已经确定了一些关键的神经元 我们还建立了重要的行为验证基础的计算。 在这项研究中，我们对灵长类动物模型进行了测量、社会背景控制和跨对确认。 将首次调查理论上构成的三个主要领域的参与情况 “社会大脑”分布式编码和调节互动社会行为的不同方面。 这些区域包括背侧前扣带皮层、前顶内区和基底外侧区 我们将专门检查自我与他人的单神经元和群体编码。 我们将测试这些表征如何。 受社会线索调节，并通过标准和标准检查不同领域的有针对性的调节 总体而言，该提案代表了一种全新的调查路线，但并非如此。 可以在人类身上进行，并开辟了神经科学中一个重要的未探索领域。 拟议的一组研究将提供灵长类动物“社交大脑”的第一个全面路线图 神经学和人口水平，并为未来的社会针对性治疗提供关键指导 行为障碍。