Neuronal based prosthetic control of volitional movement

基于神经元的意志运动假肢控制

• 批准号: 8610164
• 负责人: Ziv Williams
• 金额: $ 26.78万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8610164
• 关键词: Animals; Area; Brain Stem; Cell Nucleus; Cervical spinal cord structure; Communication; Computer Simulation; Computers; Development; Devices; Event; Feedback; Implant; Individual; Injury; Intention; Limb structure; Macaca mulatta; Measures; Modeling; Monkeys; Motor; Movement; Natural regeneration; Neuraxis; Neuronal Plasticity; Neurons; Neurostimulation procedures of spinal cord tissue; Patients; Physiologic pulse; Play; Primates; Production; Prosthesis; Retinal; Role; Social Impacts; Spinal; Spinal Cord; Spinal cord injury; Stimulus; Structure of subthalamic nucleus; System; Testing; Training; Visual; Work; abstracting; awake; base; central nervous system injury; design; disability; insight; limb movement; motor control; motor deficit; novel strategies; reconstitution; repaired; response; sensory feedback; vector; visual feedback

Abstract The inability to communicate underlies one of the most disabling aspects of injury to the central nervous system, and includes the inability to perform rudimentary tasks such as flexing and extending ones' limb or moving a simple cursor on a screen. While the majority of studies thus far have targeted the intrinsic repair or regeneration of damaged areas of the central nervous system such as brainstem or proximal cervical spinal cord, alternative approaches for redirecting information between areas that remain functionally intact is largely unexplored. Work by our group and others has demonstrated that neuronal activity in cortical and subcortical areas responsible for motor control can accurately predict volitional movement intention, and that delivery of event-related electrical stimuli in areas responsible for motor production can reproducibly alter targeted limb movement. In the current study, we aim to extend these findings by systematically matching and altering motor intent with movement production in primates performing a motor directional task. To this end, we will obtain single-neuronal recording from the same subcortical areas shown to predict motor intention and use a similar system design to deliver electrical stimuli to the ventral spinal cord in order to approximate and alter movement production. Changes in neuronal activity will be examined over multiple trials as observed movements predicted by neuronal activity are made to either correspond or mismatch movements produced by spinal cord stimulation. These findings will provide a unique perspective into the individual roles that motor neuronal plasticity and spinal efferent activity play in adaptive motor control, and may offer valuable new insight into the development of prosthetic designs aimed at restoring volitional movement.

抽象的 无法沟通是中枢神经损伤最严重的问题之一 神经系统，包括无法执行基本任务，例如弯曲和 伸展肢体或在屏幕上移动简单的光标。虽然迄今为止大多数研究 针对中枢神经系统受损区域的内在修复或再生 例如脑干或近端颈脊髓，重定向的替代方法 功能完好的区域之间的信息很大程度上尚未被探索。我们小组的工作 等人已经证明，皮质和皮质下区域的神经元活动负责 运动控制可以准确预测意志运动意图，并传递与事件相关的信息 负责运动产生的区域的电刺激可以重复地改变目标肢体 移动。在当前的研究中，我们的目标是通过系统地匹配和扩展这些发现 通过执行运动定向任务的灵长类动物的运动产生来改变运动意图。到 为此，我们将从相同的皮层下区域获得单神经元记录来预测 运动意图并使用类似的系统设计将电刺激传递到腹侧脊髓 为了近似和改变运动产生。神经元活动的变化将是 通过多项试验进行检查，因为观察到的神经元活动预测的运动是为了 脊髓刺激产生的对应或不匹配的运动。这些发现将 为运动神经元可塑性和脊髓的个体作用提供了独特的视角 传出活动在自适应运动控制中发挥作用，并可能提供有价值的新见解 开发旨在恢复意志运动的假肢设计。