StuDy AimED at Increasing AlCohol AbsTinEnce (DEDICATE)

旨在提高酒精戒断率的研究（奉献）

基本信息

批准号：
10577022
负责人：
Hagar Hallihan
金额：
$ 18.6万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10577022
关键词：
Advanced Development Affect African American Aftercare Age Alcohol consumption Alcohol dependence Alcohols Amygdaloid structure Award Behavior Therapy Benchmarking Brain region Brief Psychotherapy Chronic Disease Client satisfaction Clinical Research Collaborations Competence Complement Data Data Analyses Data Collection Disease Elderly Enrollment Ensure Environment Evaluation Evidence based treatment Female Focus Groups Functional Magnetic Resonance Imaging Future Goals Health Impairment Individual Institution Intervention Intervention Trial Interview Knowledge Leadership Life Mediating Mentors Mentorship National Institute on Alcohol Abuse and Alcoholism Neurobiology Neurosciences Outcome Participant Persons Phase Positioning Attribute Prefrontal Cortex Prevention Protocols documentation Public Health Qualitative Research Questionnaires Randomized Randomized, Controlled Trials Recommendation Research Research Methodology Research Personnel Research Training Rewards Science Senior Scientist Smoking Structure Symptoms System Target Populations Testing Therapeutic Intervention Training Treatment Efficacy Urine Ventral Striatum Woman acceptability and feasibility age group aged alcohol abstinence alcohol abuse therapy alcohol screening alcohol use disorder arm behavioral clinical trial behavioral study brain dysfunction clinically relevant cognitive control contingency management cost design effective therapy effectiveness evaluation efficacy evaluation efficacy testing experience feasibility testing follow-up functional MRI scan high risk drinking improved innovation male meetings motivational enhancement therapy negative affect neural neural circuit neuroimaging neuromechanism patient population pilot trial primary outcome problem solving therapy programs randomized, clinical trials reduced alcohol use remote delivery reward circuitry satisfaction skills therapy design therapy development treatment effect videoconference young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The long-term objective of this award is to support Dr. Hagar Hallihan, an African American woman, in advanced training in clinical research and neuroscience and establishing an independent research program. Her research program focuses on developing clinically relevant and effective integrated behavioral interventions to improve treatment efficacy and better understand the neuro mechanism of treatment for young adults with alcohol use disorder (AUD). Her mentorship team is a transdisciplinary group of senior scientists with research expertise in behavioral clinical trials, behavioral intervention development, AUD in young adults, neuroimaging data, and quantitative and qualitative research methods. She will continue working with her current T32 mentor, Dr. Ma, a senior scientist with extensive experience mentoring trainees. This will be complemented by content and mentoring expertise from Drs. Ajilore, Rospenda, and Wu. Collectively, this team will provide an outstanding training environment that will allow Dr. Hallihan to fill critical gaps in her knowledge and skill set relating to the study of behavior interventions and neural mechanisms underlying treatment for young adults with AUD. Her training goals are to develop skills in (1) designing and assessing effectiveness of mechanistic randomized clinical trials, (2) competency in statistical and fMRI data analyses, and (3) knowledge and skills in the neurobiology of alcohol addiction. In addition, she will develop professional skills in scientific leadership and interdisciplinary team science. Achieving these goals will strengthen her scholarly activities, establish important collaborations, and acquire critical data that will ensure her successful transition to independence. The proposed research plan builds on Dr. Hallihan’s prior research training in AUD among young adults. AUD, a chronic disease of impaired ability to stop or control alcohol use, is a costly major public health problem, most prevalent in young adults (aged18-24 yr). Heavy alcohol consumption impairs brain structure and function, more severely in young adults than in older adults. However, evidence-based treatments for AUD in young adults are lacking, and the neural mechanisms following available behavior treatments are poorly understood. The aims of the K99 phase are (1) to develop an integrated contingency management (CM) and Problem-Solving Therapy (PST), CM-PST intervention to improve alcohol abstinence among young adults with AUD, and (2) test feasibility and acceptability of the intervention. The aims of the R00 phase are to (1) test the efficacy of CM-PST vs CM alone in a 2-arm pilot RCT, and (2) assess neural mechanisms associated with CM-PST treatment effects in young adults with AUD. Support from this award will enable Dr. Hallihan to launch an independent program of research that contributes to the field by 1) developing and implementing an innovative intervention to improve alcohol abstinence among young adults with AUD, and 2) assess neural mechanisms of successful treatment among young adults with AUD to inform future intervention and prevention efforts and ultimately reduce the public health burden of AUD.

项目概要/摘要该奖项的长期目标是支持非裔美国女性 Hagar Hallihan 博士临床研究和神经科学方面的高级培训以及建立独立的研究计划。她的研究项目侧重于开发临床相关且有效的综合行为旨在提高治疗效果并更好地了解年轻人治疗的神经机制的干预措施她的指导团队是一个由资深科学家组成的跨学科小组。拥有行为临床试验、行为干预开发、年轻人 AUD 方面的研究专业知识，她将继续与她一起研究神经影像数据以及定量和定性研究方法。现任T32导师马博士是一位资深科学家，拥有丰富的指导学员经验。辅以 Ajilore、Rospenda 和 Wu 博士的内容和指导专业知识。团队将提供出色的培训环境，使 Hallihan 博士能够填补她的关键空白与行为干预和神经机制研究相关的知识和技能她的培训目标是培养 (1) 设计和评估方面的技能。机械随机临床试验的有效性，(2) 统计和功能磁共振成像数据分析能力，（3）酒精成瘾神经生物学方面的知识和技能此外，她还将发展专业知识。科学领导和跨学科团队科学的技能将增强她的能力。学术活动，建立重要的合作，并获取关键数据，以确保她的成功拟议的研究计划以 Hallihan 博士之前在 AUD 的研究培训为基础。在年轻人中，AUD 是一种导致停止或控制饮酒能力受损的慢性疾病，是一种昂贵的疾病。公共健康问题，最常见于年轻人（18-24 岁）。大脑结构和功能，年轻人比老年人更严重。然而，这是有证据支持的。年轻人 AUD 的治疗方法尚缺乏，并且现有行为的神经机制 K99 阶段的目标是 (1) 制定综合应急方案。管理（CM）和问题解决疗法（PST），CM-PST 干预以改善戒酒患有 AUD 的年轻人，以及 (2) 测试干预措施的可行性和可接受性 R00 的目标。该阶段的目标是 (1) 在 2 组试点随机对照试验中测试 CM-PST 与单独 CM 的功效，以及 (2) 评估神经该奖项将支持与 CM-PST 对年轻人的治疗效果相关的机制。使 Hallihan 博士能够启动一项独立的研究计划，该计划通过以下方式对该领域做出贡献：1) 开发实施创新干预措施，以改善患有 AUD 的年轻人的戒酒情况，以及 2) 评估患有 AUD 的年轻人成功治疗的神经机制，为未来提供信息干预和预防工作，最终减轻澳元的公共卫生负担。