Race, Natriuretic Peptides and Physiological Perturbations

种族、利尿钠肽和生理干扰

基本信息

批准号：
10591601
负责人：
Pankaj Arora
金额：
$ 19.38万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10591601
关键词：
Adipose tissue Adrenergic beta-Antagonists Adult African American African American population Alabama Atrial Natriuretic Factor Award Biological Biometry Brain natriuretic peptide Cardiovascular Diseases Cardiovascular system Cerebrovascular Disorders Cessation of life Classification Clinical Clinical Research Collection Cyclic GMP Development Diet Disease Disease susceptibility Enrollment Epidemiology Ethics Excretory function Exercise Exercise Physiology Five-Year Plans Funding Genetic Genetic Markers Goals Grant Heart Heart Atrium Heart failure High Prevalence Hormones Hospitalization Human Hypertension Impairment Individual International Intervention Intervention Studies Kidney Knowledge Leadership Master of Science Measures Medicine Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Metabolic Metabolism Methods Metoprolol Metoprolol Succinate Muscle N-terminal Natriuretic Peptides Outcome Oxygen Participant Patients Pharmaceutical Preparations Pharmacology Study Physiological Physiology Prevalence Principal Investigator Production Protocols documentation Public Health Public Health Schools Race Renin-Angiotensin-Aldosterone System Research Research Design Research Personnel Rest Skeletal Muscle Sodium Sodium Chloride Standardization Stress System Systems Biology Testing Therapeutic Thinness Time Training Translational Research Underrepresented Minority Universities VO2max Vasodilation Work Writing antagonist cardiovascular disorder risk cardiovascular health collaborative environment community engagement design efficacy testing ethnic disparity experience genetic testing health disparity hemodynamics hypertension treatment insight interest new therapeutic target normotensive novel therapeutics patient oriented patient oriented research personalized medicine pharmacologic physiologic stressor primary endpoint pro-brain natriuretic peptide (1-76)professor programs racial difference racial disparity racial population recruit response saluretic secondary endpoint skills social social health determinants uptake urinary valsartan

项目摘要

PROJECT SUMMARY/ABSTRACT The applicant, Pankaj Arora, MD is an Assistant Professor of Medicine in the Division of Cardiovascular Disease at University of Alabama at Birmingham. The applicant’s goal is to become an independent investigator in clinical and translational research and advance the understanding of how disorders in the natriuretic peptide (NP) system contribute to the development of hypertension, heart failure and cardiovascular disease. The applicant has shown a prior interest in understanding the genetics, NP system biology and an ability to conduct high-quality patient-oriented research. This Mentored Patient-Oriented Research Career Development Award (K23) describes a five-year plan that will allow the applicant to achieve independence as an investigator, under the primary mentorship of Thomas J. Wang MD, an internationally-recognized leader in the field of NP physiology. The applicant wishes to obtain knowledge and expertise in 4 specific domains: (1) patient-oriented physiologic studies, (2) the pathophysiologic basis of race-related differences in cardiovascular disease susceptibility, (3) exercise physiology, and (4) patient-oriented pharmacologic studies. African-Americans have increased prevalence of cardiovascular disease which contributes to racial disparities in outcomes such as death and hospitalization. NPs are natriuretic and vasodilatory hormones produced by the heart in response to increased wall stress in the atria and ventricles. In preliminary work for this proposal, we found that African-American race is associated with NP deficiency. Little is known about the physiological consequences of the lower resting NP levels found in African-Americans. The current proposal will seek to determine if there exists racial differences in how the heart responds to physiological perturbations such as exercise and beta blockers. The specific aims are (1) To compare the NP response to beta blockers in African- American and white individuals (2) To compare the NP response to exercise in African-American and white individuals. Understanding these differences in release of NPs may have biological and therapeutic importance in the treatment of hypertension and heart failure. The Mentored Patient-Oriented Research Career Development award (K23) will provide Dr. Arora with the necessary time to fully engage in multifaceted, carefully designed patient-oriented research protocols while serving as a means to receive additional formal didactics. During the course of the award period, the applicant will pursue a Master of Science in Public Health in Clinical & Translational Science at UAB’s School of Public Health to advance his skills in patient-oriented research (epidemiology, biostatistics, study design, grant- writing, and leadership courses). UAB’s rich collaborative, interdisciplinary environment with national recognition for community engagement will provide Dr. Arora with a platform to successfully conduct the research proposed in the plan. The proposed studies will prepare the investigator to design and conduct interventional studies (e.g. R01) in specific racial subgroups to personalize existing and novel therapeutics around the NP system.

项目概要/摘要申请人 Pankaj Arora 医学博士是心血管科医学助理教授阿拉巴马大学伯明翰分校的疾病申请人的目标是成为一名独立的人。临床和转化研究的研究者，并促进对疾病如何在利钠肽（NP）系统有助于高血压、心力衰竭和心血管疾病的发生申请人已表现出对了解遗传学、NP 系统生物学和疾病的兴趣。进行高质量的以患者为导向的研究的能力。发展奖（K23）描述了一个五年计划，该计划将允许申请人实现独立性：一名研究员，在国际公认的领导者 Thomas J. Wang 医学博士的指导下申请人希望获得 4 个特定领域的知识和专业知识：(1) 以患者为导向的生理学研究，（2）心血管种族相关差异的病理生理学基础疾病易感性，（3）运动生理学，以及（4）以患者为导向的药理学研究。非裔美国人心血管疾病患病率增加，导致种族差异 NP 是由利尿钠和血管舒张激素产生的。心脏对心房和心室壁应力增加的反应在该提案的初步工作中，我们发现非裔美国人与 NP 缺乏有关，但对其生理学知之甚少。当前的提案将寻求解决非裔美国人静息 NP 水平较低的后果。确定心脏对生理扰动的反应是否存在种族差异，例如具体目标是 (1) 比较非洲人对 NP 的反应美国人和白人 (2) 比较非裔美国人和白人对运动的 NP 反应了解纳米粒子释放的这些差异可能具有生物学和治疗意义。在治疗高血压和心力衰竭方面具有重要意义。以患者为导向的研究职业发展奖 (K23) 将为阿罗拉博士提供充分参与多方面、精心设计的以患者为导向的研究方案的必要时间，同时作为在奖励期间接受额外正式教学的一种手段。将在阿拉巴马大学公立学院攻读临床和转化科学公共卫生理学硕士学位健康以提高他在以患者为导向的研究方面的技能（流行病学、生物统计学、研究设计、资助）写作和领导力课程）。对社区参与的认可将为阿罗拉博士提供一个成功开展研究的平台计划中提出的研究将为研究者设计和进行做好准备。针对特定种族亚组的干预研究（例如 R01），以个性化现有和新型疗法围绕NP系统。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Coronary Artery Calcium Score for Personalization of Antihypertensive Therapy: A Pooled Cohort Analysis.

用于个性化抗高血压治疗的冠状动脉钙评分：合并队列分析。

DOI：
发表时间：
2021-04
期刊：
影响因子：
0
作者：
Parcha, Vibhu;Malla, Gargya;Kalra, Rajat;Li, Peng;Pandey, Ambarish;Nasir, Khurram;Arora, Garima;Arora, Pankaj
通讯作者：
Arora, Pankaj

Diagnostic and prognostic implications of heart failure with preserved ejection fraction scoring systems.

保留射血分数评分系统的心力衰竭的诊断和预后意义。

DOI：
发表时间：
2021
期刊：
影响因子：
3.8
作者：
Parcha, Vibhu;Malla, Gargya;Kalra, Rajat;Patel, Nirav;Sanders;Pandey, Ambarish;Shah, Sanjiv J;Arora, Garima;Arora, Pankaj
通讯作者：
Arora, Pankaj

Trends and Geographic Variation in Acute Respiratory Failure and ARDS Mortality in the United States.

美国急性呼吸衰竭和 ARDS 死亡率的趋势和地理变化。