Wearable Monitor for Recording the Activity of Brown Adipose Tissue

用于记录棕色脂肪组织活动的可穿戴监视器

• 批准号: 8779862
• 负责人: FRED STERZER
• 金额: $ 14.99万
• 依托单位: MMTC, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8779862
• 关键词: Adrenergic beta-Antagonists; Adult; Adverse effects; Affect; Alcohol consumption; Authorization documentation; Brown Fat; Burn injury; Caffeine; Calories; Cause of Death; Child; Clothing; Data Storage and Retrieval; Desire for food; Development; Devices; Diabetes Mellitus; Digestive System Disorders; Drug usage; Elements; Energy Metabolism; Equipment; Exploratory/Developmental Grant; Exposure to; Fatty acid glycerol esters; Funding; Goals; Hour; Human Volunteers; Individual; Institutes; Institutional Review Boards; Joints; Kidney Diseases; Measurement; Measures; Medical; Memory; Metabolic; Methods; Modeling; Monitor; Noise; Obesity; Pharmaceutical Preparations; Phase; Positron-Emission Tomography; Prevalence; Procedures; Process; Protocols documentation; Public Health; Relative (related person); Reporting; Scanning; Simulate; Site; Skin; Small Business Innovation Research Grant; Smoking; Temperature; Testing; Time; Tissues; Universities; Variant; Vertebral column; Weather; combat; design; diet and exercise; digital; dosage; drug development; fighting; improved; instrument; instrumentation; microwave electromagnetic radiation; miniaturize; operation; programs; prototype; public health relevance

DESCRIPTION (provided by applicant): Brown Adipose Tissues (BAT) are tissues that when activated become metabolically active and take calories from normal white fat and burn them. Safe methods for creating and activating (BAT) would therefore be of great value in fighting obesity, a leading preventable cause of death with increasing prevalence in adults and children and one of the most serious public health problems of the 21st century. Current efforts to develop BAT stimulation paradigms are hindered by the inability to continuously monitor the activity of BAT with available medical scans. Positron Emission Tomography (PET) scans and other similar types of scanners that can detect activated BAT use large, expensive equipment and are only useful for providing single snapshots in time of the existence of activated BAT. The proposed Phase I SBIR program is for the development of monitors that can safely, noninvasively, and continuously record the activity of BAT of an individual over a period of at least 24 hours and that can be worn by the individuals while carrying out their normal activities. The wearable BAT monitors will be miniaturized and improved versions of the large instruments that were successfully used (P<0.01) to detect activated BAT by measuring the microwave thermal noise emitted by activated BAT in a recently completed joint Johns Hopkins University/MMTC R21 program funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) entitled "Non-Invasive Measurements of Brown Adipose Tissues", and will include miniaturized devices for storing the measured activity of BAT for periods of at least 24 hours. The availability of wearable continuous BAT activation monitors would be of great value not only in the development of drugs that can activate BAT without causing unacceptable side effects, the first obesity drugs that would affect energy expenditure rather than appetite, but also in answering the following types of important questions: How long do activations and degree of activations of BAT due to exposure to cold last as functions of durations of exposures and temperatures? How long and how deep do deactivations of BAT due to adrenergic beta-blockers last as functions of dosages and are there other widely used drugs that deactivate BAT? To what extend do exercise, diet, smoking, consumption of alcohol, caffeine, type of clothing in cold weather, etc., affect the activity of BAT? For any safe drugs tht can enhance the metabolic activity of BAT, how long does this activation last, how much of such drugs does a particular individual have to take to get a significant increase in the metabolic activity of BAT?

描述（由申请人提供）：棕色脂肪组织（BAT）是一种组织，当被激活时，其代谢变得活跃，从正常白色脂肪中获取热量并燃烧它们。因此，安全的创造和激活方法 (BAT) 在对抗肥胖方面具有重要价值，肥胖是一种可预防的主要死亡原因，在成人和儿童中患病率不断增加，也是 21 世纪最严重的公共卫生问题之一。目前开发 BAT 刺激范例的努力因无法利用现有的医学扫描持续监测 BAT 的活动而受到阻碍。正电子发射断层扫描 (PET) 扫描和其他类似类型的可检测激活的 BAT 的扫描仪使用大型、昂贵的设备，并且仅适用于在激活的 BAT 存在时提供单个快照。拟议的第一阶段 SBIR 计划旨在开发能够安全、无创、连续记录个人至少 24 小时内 BAT 活动的监视器，并且个人可以在进行正常活动时佩戴该监视器。可穿戴式 BAT 监测器将是大型仪器的小型化和改进版本，这些仪器在最近完成的约翰·霍普金斯大学/MMTC R21 资助的联合项目中，通过测量激活的 BAT 发出的微波热噪声，成功地用于检测激活的 BAT（P<0.01）。由国家糖尿病、消化和肾脏疾病研究所 (NIDDK) 题为“棕色脂肪组织的非侵入性测量”，并将包括用于存储的小型化设备测量至少 24 小时内 BAT 的活动。可穿戴式连续 BAT 激活监测仪的出现不仅对于开发能够激活 BAT 而不会引起不可接受的副作用的药物（第一种会影响能量消耗而不是食欲的肥胖药物）具有重要价值，而且还可以回答以下类型重要问题：由于暴露于寒冷而导致的 BAT 激活和激活程度会持续多长时间，作为暴露持续时间和温度的函数？肾上腺素能 β 受体阻滞剂导致 BAT 失活的持续时间和深度与剂量有关，是否还有其他广泛使用的使 BAT 失活的药物？运动、饮食、吸烟、饮酒、咖啡因、寒冷天气的衣服类型等在多大程度上影响 BAT 的活性？对于任何可以增强 BAT 代谢活性的安全药物，这种激活持续多长时间？特定个体需要服用多少此类药物才能显着提高 BAT 代谢活性？