BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM

共同促进大脑健康：基于小组的直播数字节目

• 批准号: 10747235
• 负责人: Deborah E. Barnes
• 金额: $ 5万
• 依托单位: TOGETHER SENIOR HEALTH, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10747235
• 关键词: Address; Aging; Alzheimer' s disease related dementia; Awareness; Behavior Therapy; Businesses; Caregivers; Dedications; Dementia; Development; Elderly; Evidence based program; Exercise; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Home; Impaired cognition; Informal Social Control; Intervention; Maintenance; Market Research; Marketing; Mental Depression; Movement; Persons; Pharmaceutical Preparations; Phase; Physical Function; Positioning Attribute; Quality of life; Randomized, Controlled Trials; Rest; Risk; Scanning; Small Business Innovation Research Grant; Social isolation; Testing; Woman; Work; brain health; cognitive benefits; cognitive function; comparison group; daily functioning; dementia risk; design; digital; evidence base; human centered design; improved; innovation; live stream; mild cognitive impairment; mindfulness; physical inactivity; prevent; programs; social engagement

Together Senior Health, Inc. (TOGETHER) is a woman-owned small business that is dedicated to helping older adults with cognitive decline or Alzheimer’s disease and related dementias (ADRD) maintain quality of life and independence by offering innovative, evidence-based, online, livestream, group programs. Our first product on the TOGETHER audio/video platform is Moving TogetherTM—which combines movements to support daily function with mindful body awareness exercises and social engagement and is designed for people with mild ADRD and their caregivers who participate together from home. The primary goal of our Phase II Small Business Innovation Research (SBIR) grant is to expand our product line by developing and testing a comprehensive BRAIN HEALTH TOGETHER program for people living with mild cognitive impairment (MCI). There are no medications that can prevent development of ADRD in people with MCI; however, there is growing evidence that behavioral interventions targeting modifiable dementia risk factors—such as physical inactivity, social isolation, and depression—may help improve cognitive function and could potentially delay dementia onset. Our preliminary results suggest that our product, Moving Together, is associated with significant improvements in cognitive function, physical function, social isolation, and self-regulation as well as increased default mode network connectivity on pre/post resting state functional magnetic resonance imaging (rs-fMRI) scans in people with MCI. We believe that these benefits would be even greater if Moving Together were combined with a comprehensive brain health coaching program. Our Phase II Specific Aims are to: 1) Work with our Scientific Advisory Board and use human-centered design to develop evidence-based content for Brain Health Together, a 12-week, group-based, live-streaming, digital program that will combine Moving Together with brain health coaching to address modifiable dementia risk factors in people with MCI; 2) Perform a randomized, controlled trial to determine whether the Brain Health Together program improves cognitive function in people with MCI over 12 weeks compared to a Successful Aging comparison group; and 3) Determine whether weekly maintenance classes help to sustain the effects of the Brain Health Together program over 12 weeks after the intervention. If we can demonstrate that BRAIN HEALTH TOGETHER has immediate and sustained cognitive benefits in people with MCI, it will position TOGETHER as a national leader in evidence-based programs to improve quality of life and prevent decline in older adults with cognitive impairment. Technical and Business Assistance (TABA) funding will enable TOGETHER to access external market research expertise to identify and position our BRAIN HEALTH TOGETHER program with different potential user segments with targeted messages and meaningful content that is most relevant to each segment.

Together Senior Health, Inc. (TOGETHER) 是一家女性拥有的小型企业，致力于帮助老年人 患有认知能力下降或阿尔茨海默氏病和相关痴呆症 (ADRD) 的成年人可以维持生活质量 通过提供创新的、基于证据的、在线、直播、团体项目来实现独立。 TOGETHER 音频/视频平台是 Moving TogetherTM，它结合了运动来支持日常工作 具有正念身体意识练习和社交参与的功能，专为轻度患者设计 ADRD 及其护理人员在家中一起参与我们第二阶段小型项目的主要目标。 商业创新研究 (SBIR) 拨款旨在通过开发和测试 针对轻度认知障碍患者的全面“BRAIN HEALTH TOGETHER”计划 (MCI)。但是，没有药物可以预防 MCI 患者出现 ADRD； 越来越多的证据表明，针对可改变的痴呆风险因素（例如身体状况）的行为干预 缺乏活动、社交孤立和抑郁——可能有助于改善认知功能，并可能延迟 我们的初步结果表明，我们的产品“一起移动”与痴呆症的发病有关。 认知功能、身体功能、社会隔离和自我调节以及 增加静息态功能磁共振成像前/后的默认模式网络连接 (rs-fMRI) 对 MCI 患者进行扫描 我们相信，如果“一起行动”，这些好处会更大。 与全面的大脑健康辅导计划相结合，我们的第二阶段具体目标是：1) 与我们的科学顾问委员会合作，使用以人为本的设计来开发基于证据的内容 Brain Health Together 是一个为期 12 周、以小组为基础的直播数字项目，将结合移动 与大脑健康辅导一起解决 MCI 患者的可改变的痴呆风险因素 2) 执行； 一项随机对照试验，旨在确定 Brain Health Together 计划是否可以改善认知能力 与成功衰老对照组相比，MCI 患者的功能超过 12 周；3) 确定每周维护课程是否有助于维持大脑健康的影响 如果我们能够证明“BRAIN HEALTH TOGETHER”已在干预后 12 周内实施。 为 MCI 患者带来即时和持续的认知益处，它将共同定位为国家领导者 参与以证据为基础的计划，以改善老年人的生活质量并防止认知能力下降 技术和商业援助 (TABA) 资金将使 TOGETHER 能够获得援助。 外部市场研究专业知识来确定和定位我们的“BRAIN HEALTH TOGETHER”计划 不同的潜在用户群，具有针对性的消息和有意义的内容，这是最重要的 与每个细分市场相关。