BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM

共同促进大脑健康：基于小组的直播数字节目

• 批准号: 10493302
• 负责人: Deborah E. Barnes
• 金额: $ 97.91万
• 依托单位: TOGETHER SENIOR HEALTH, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493302
• 关键词: Address; Age; Aging; Alzheimer' s disease related dementia; American; Awareness; Behavior Therapy; Blood Pressure; Brain; Businesses; Caregivers; Clinical; Cognitive; Control Groups; Dementia; Development; Diabetes Mellitus; Elderly; Emotional; Evidence based program; Exercise; Goals; Health; Home; Hypertension; Impaired cognition; Informal Social Control; Intervention; Life Style; Maintenance; Mediating; Mental Depression; Mission; Movement; Outcome; Participant; Personal Satisfaction; Persons; Pharmaceutical Preparations; Phase; Physical Function; Positioning Attribute; Process; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Research Proposals; Rest; Risk; Risk Factors; Risk Reduction; Small Business Innovation Research Grant; Social isolation; Techniques; Testing; Training; Vulnerable Populations; Woman; Work; base; brain health; cognitive benefits; cognitive function; comparison group; daily functioning; dementia risk; design; diabetes management; dietary supplements; digital; evidence base; exercise program; experience; functional MRI scan; group intervention; human centered design; improved; improved functioning; innovation; live stream; mild cognitive impairment; mindfulness; modifiable risk; phase 1 study; physical inactivity; prevent; programs; social; social engagement; trial comparing; virtual

Together Senior Health, Inc. (TOGETHER) is a woman-owned small business that is dedicated to helping older adults with cognitive decline or Alzheimer’s disease and related dementias (ADRD) maintain quality of life and independence by offering innovative, evidence-based, online, livestream, group programs. Our first product on the TOGETHER audio/video platform is Moving TogetherTM—which combines movements to support daily function with mindful body awareness exercises and social engagement and is designed for people with mild ADRD and their caregivers who participate together from home. The primary goal of this Phase II Small Business Innovation Research (SBIR) grant is to expand our product line by developing and testing a comprehensive BRAIN HEALTH TOGETHER program for people living with mild cognitive impairment (MCI). This goal represents a critically important next step for our company from both public health and business perspectives. Older adults with MCI represent a large market with important unmet needs: approximately 20% of older adults (>2.7 million Americans) are currently living with MCI, which places them at increased risk of developing ADRD. There are no medications that can prevent development of ADRD in people with MCI; however, there is growing evidence that behavioral interventions targeting modifiable dementia risk factors—such as physical inactivity, social isolation, and depression—may help improve cognitive function and could potentially delay dementia onset. Our preliminary results suggest that our product, Moving Together is associated with significant improvements in cognitive function, physical function, social isolation, and self-regulation as well as increased default mode network connectivity on pre/post resting state functional magnetic resonance imaging (rs-fMRI) scans in people with MCI. We believe that these benefits would be even greater if Moving Together were combined with a comprehensive brain health coaching program. Therefore, our Specific Aims are to: 1) Work with our Scientific Advisory Board and use humancentered design to develop evidence-based content for Brain Health Together, a 12-week, group-based, livestreaming, digital program that will combine Moving Together with brain health coaching to address modifiable dementia risk factors in people with MCI; 2) Perform a randomized, controlled trial to determine whether the Brain Health Together program improves cognitive function in people with MCI over 12 weeks compared to a Successful Aging comparison group; and 3) Determine whether weekly maintenance classes help to sustain the effects of the Brain Health Together program over 12 weeks after the intervention. If we can demonstrate that BRAIN HEALTH TOGETHER has immediate and sustained cognitive benefits in people with MCI, it will position TOGETHER as a national leader in evidence-based programs to improve quality of life and prevent decline in older adults with cognitive impairment.

Together Senior Health, Inc. (TOGETHER) 是一家女性拥有的小型企业，致力于帮助 患有认知能力下降或阿尔茨海默病及相关痴呆症 (ADRD) 的老年人可维持生活质量 通过提供创新、循证、在线、直播、团体项目来实现独立性。 TOGETHER 音频/视频平台上的产品是 Moving Together™——它将动作结合起来 通过正念身体意识练习和社交参与来支持日常功能，专为 患有轻度 ADRD 的人及其护理人员在家中一起参与该活动的主要目标。 第二阶段小型企业创新研究 (SBIR) 拨款旨在通过开发来扩展我们的产品线 并针对轻度认知障碍患者测试全面的“BRAIN HEALTH TOGETHER”计划 这一目标对我们公司来说是至关重要的下一步。 患有 MCI 的老年人代表了一个巨大的市场，其重要的未满足需求： 大约 20% 的老年人（超过 270 万美国人）目前患有 MCI，这使他们处于 发生 ADRD 的风险增加 没有药物可以预防 ADRD 的发生。 然而，越来越多的证据表明，行为干预的目标是可改变的 痴呆症风险因素——例如缺乏身体活动、社交孤立和抑郁——可能有助于改善 认知功能，并可能延缓痴呆症的发作。我们的初步结果表明，我们的产品， 一起运动与认知功能、身体功能、社交功能的显着改善相关 隔离和自我调节以及在静息状态前/后增加默认模式网络连接 我们相信功能性磁共振成像 (rs-fMRI) 扫描对 MCI 患者有这些好处。 如果“一起行动”与全面的大脑健康辅导相结合，效果会更好 因此，我们的具体目标是： 1) 与我们的科学顾问委员会合作并使用 以人为本的设计，为 Brain Health Together 开发基于证据的内容，这是一个为期 12 周、基于小组的、 直播数字节目将“一起移动”与大脑健康辅导相结合，以解决 MCI 患者可改变的痴呆危险因素；2) 进行随机对照试验以确定 Brain Health Together 计划是否可以在 12 周内改善 MCI 患者的认知功能 与成功老化对照组进行比较；以及 3) 确定是否每周进行维护课程 如果可以的话，帮助维持 Brain Health Together 计划的效果超过 12 周。 证明“BRAIN HEALTH TOGETHER”对以下方面具有直接和持续的认知益处： 患有 MCI 的人，它将共同定位为循证计划的国家领导者，以 改善生活质量并防止患有认知障碍的老年人的衰退。