T32 Translational Addiction Research Fellowship Program

T32 转化成瘾研究奖学金计划

基本信息

批准号：
10628649
负责人：
Julie A Blendy
金额：
$ 32.91万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628649
关键词：
Fellowship Program Research addiction

项目摘要

Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. These inter-related problems have only worsened during the global COVID-19 pandemic, still ongoing. We need to speed the "forward" translation of recent neuroscience and neurogenetic knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in "backward-translation" -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translational researchers, this application proposes continuation of a successful (32 total trainees; 16 in the current funding period) NIDA T32 Translational Addiction Research Fellowship at the University of Pennsylvania. The training program (4 pre- and 4 post- doctoral positions) makes explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.s or M.D.s, who will accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Blendy), the internal and external advisors, the formal didactics, the "dual" (clinical - preclinical) journal clubs, and in the trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi- determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma, stress, cultural norms) influences. Trainees are thus offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging, including PET), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in several interacting academic research entities (Penn Center for Studies on Addiction; Translational Research Laboratories/CNB; Center for AIDS Research; Penn PET Center; the Complex Systems Lab) offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, local opioid treatment clinics, and mobile HIV Prevention units), critical for translating new research findings into the "real world”.

成瘾以及艾滋病毒传播、犯罪和暴力等相关公共卫生问题造成了严重的后果每年在医疗保健、生产力损失和监禁方面造成数十亿美元的损失，这些都是相互关联的。在全球新冠肺炎 (COVID-19) 大流行期间，问题只会变得更加严重，而且我们需要加快这一进程。将最新的神经科学和神经遗传学知识“向前”转化为更有效的临床治疗对于线下的成瘾，对于具有某些已知功效的成瘾治疗，我们现在可以应用新的。 “向后翻译”中的神经科学和遗传工具——例如，找出为什么某种治疗方法对某些人有效个人，但根本不适合其他人，为了帮助满足熟练的转化研究人员的需求，此应用程序。建议继续成功开展（总共 32 名受训人员；当前资助期间有 16 名）NIDA T32 转化项目宾夕法尼亚大学成瘾研究奖学金。培训计划（4 期前和 4 期后）。博士职位）明确了宾夕法尼亚大学长期的翻译传统，将临床和基础相结合研究优势来培养实习生，无论是临床还是临床前，博士还是医学博士，他们将加速未来十年对翻译的重视体现在该计划的各个层面 - 通过 Co-PI（临床和基础，Childress 和 Blendy 博士）、内部和外部顾问、正式的教学法、“双重”（临床 - 临床前）期刊俱乐部以及受训者指导的研究项目。该计划的翻译重点是认识到成瘾是一种复杂的疾病、多因素由遗传脆弱性、药物暴露和一系列调节因素（例如早期创伤、压力、文化规范）的影响因此为学员提供了有关这些的最先进的知识。通过特定于该计划的教学系列以及通过指导项目来相互作用的决定因素范围可能从分子和遗传学研究到大脑系统（神经科学和神经影像学，包括 PET），到临床治疗试验和药物政策，这种广泛的选择是由悠久的历史实现的。大学在成瘾研究方面的卓越表现，体现在几个相互作用的学术研究实体中（宾夕法尼亚大学成瘾研究中心；转化研究实验室/CNB；艾滋病研究中心；宾夕法尼亚大学 PET 中心；复杂系统实验室）为该奖学金提供熟练、成功的导师。研究还在多个附属治疗机构（VA、Presby-Penn、当地阿片类药物治疗）中进行诊所和流动艾滋病毒预防单位），这对于将新研究成果转化为“现实世界”至关重要。

项目成果

期刊论文数量（68）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Epigenetic inheritance of a cocaine-resistance phenotype.

可卡因抗性表型的表观遗传。

DOI：
发表时间：
2013-01
期刊：
影响因子：
25
作者：
Vassoler, Fair M;White, Samantha L;Schmidt, Heath D;Sadri;Pierce, R Christopher
通讯作者：
Pierce, R Christopher

Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors.

α4β2*/α6β2* 烟碱受体的激活可减轻尼古丁戒断期间的焦虑，而不会上调烟碱受体。

DOI：
发表时间：
2014-05
期刊：
影响因子：
0
作者：
Yohn, Nicole L;Turner, Jill R;Blendy, Julie A
通讯作者：
Blendy, Julie A

Impaired cocaine-induced behavioral plasticity in the male offspring of cocaine-experienced sires.

经历过可卡因的雄性后代的可卡因诱导的行为可塑性受损。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Wimmer, Mathieu E;Vassoler, Fair M;White, Samantha L;Schmidt, Heath D;Sidoli, Simone;Han, Yumiao;Garcia, Benjamin A;Pierce, R Christopher
通讯作者：
Pierce, R Christopher

Sustained brain response to repeated drug cues is associated with poor drug-use outcomes.

大脑对重复药物提示的持续反应与不良的药物使用结果有关。

DOI：
发表时间：
2021-09
期刊：
影响因子：
3.4
作者：
Regier, Paul S;Jagannathan, Kanchana;Franklin, Teresa R;Wetherill, Reagan R;Langleben, Daniel D;Gawyrsiak, Michael;Kampman, Kyle M;Childress, Anna Rose
通讯作者：
Childress, Anna Rose

Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice.

可卡因对雄性和雌性小鼠 Nr4a1 染色质二价和 mRNA 的调节。