T32 Translational Addiction Research Fellowship Program

T32 转化成瘾研究奖学金计划

• 批准号: 10400087
• 负责人: Julie A Blendy
• 金额: $ 51.64万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400087
• 关键词: Fellowship Program; Research; addiction

Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the "forward" translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in "backward- translation" -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translational researchers, this application proposes continuation of a successful (17 total trainees; 13 in the current funding period) NIDA T32 Translational Addiction Research Fellowship at the University of Pennsylvania. The (pre- and postdoctoral) training program make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.s or M.D.s, who will accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the "dual" (clinical - preclinical) mentoring, and in the trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma ,stress, cultural norms) influences. Trainees are thus offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn Center for Studies on Addiction; Translational Research Laboratories/CNB; Center for AIDS Research; Center for Integrated Nicotine Research (CIRNA), the Treatment Research Institute, and collaborative laboratories offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the "real world”.

成瘾以及艾滋病毒传播、犯罪和暴力等相关公共卫生问题造成了严重的后果 每年在医疗保健、生产力损失和监禁方面造成数十亿美元的损失。 神经科学和遗传学在过去二十年里取得了飞速的进步，我们需要加快“前进”的速度 将这些知识转化为更有效的离线成瘾临床治疗方法。 具有一些已知功效的治疗方法，我们现在可以在“向后- 翻译”——例如，找出为什么某种治疗方法对某些人有效，但对另一些人则完全无效。 为了满足熟练的转化研究人员的需求，该申请提出了成功的延续（17 受训人员总数；当前资助期间 13 名）NIDA T32 转化成瘾研究奖学金 宾夕法尼亚大学（博士前和博士后）培训计划明确了长期存在的目标。 宾夕法尼亚大学的转化传统，整合临床和基础研究优势来培养实习生，无论是 临床或临床前、博士或医学博士，他们将在未来十年加速成瘾科学的发展。 对翻译的关注反映在该计划的各个层面 - 通过 Co-PI（临床和基础，Childress 博士） 皮尔斯），内部和外部顾问委员会成员，正式的教学法，“双重”（临床 - 临床前）指导，以及受训者指导的研究项目。 该计划的驱动因素是认识到成瘾是一种复杂的疾病，由多种因素的相互作用决定。 遗传脆弱性、接触毒品以及一系列调节因素（例如早期创伤、压力、文化规范） 因此，学员可以通过以下方式获得有关这些相互作用的决定因素的最新知识。 针对该计划的教学系列，并通过指导项目，范围可能从分子和 遗传学研究、脑系统（神经科学和神经影像学）、临床治疗试验和药物政策。 这种广泛的选择得益于大学在成瘾研究方面的悠久历史， 反映在几个学术研究中心（宾夕法尼亚大学成瘾研究中心；转化 研究实验室/CNB；艾滋病研究中心；综合尼古丁研究中心 (CIRNA) 治疗研究所和合作实验室为患者提供熟练、成功的导师 指导研究也在几个附属治疗机构（VA、Presby-Penn、 社区美沙酮诊所和流动艾滋病毒预防单位），对于转化新研究成果至关重要 进入“现实世界”。