Cancer Chemical Biology and Metabolism Training Program

癌症化学生物学与代谢培训项目

基本信息

批准号：
10599241
负责人：
Nika N Danial
金额：
$ 35.92万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10599241
关键词：
Biology Chemicals Malignant Neoplasms Metabolism Training Programs

项目摘要

Project Summary/Abstract The faculty of the Dana-Farber Cancer Institute (DFCI) is requesting funds to support a new, integrative, postdoctoral training program in Cancer Chemical Biology and Metabolism (CCBM) — two synergistic and conceptually related research disciplines grounded in small molecule chemistry and biochemistry that are of growing importance from both basic and translational research perspectives. The goals of this program are to: 1) provide training in a wide range of topics relevant to cancer chemical biology and metabolism such as preclinical cancer target validation, chemical screens, structure-based drug discovery, tumor metabolism, cross-talk between tumor and host metabolism, cellular bioenergetics and metabolomics, mechanistic biochemistry, proteomics and chemoproteomics, and animal tumor modelling; 2) familiarize trainees with state- of-the-art technologies and approaches in chemical biology and metabolic science, 3) train fellows to identify important questions and approaches that will move the field forward and provide translational opportunities to impact cancer treatment; 4) provide trainees with opportunities to develop and enhance their grantsmanship and scientific communication skills; 5) coach fellows on their paths to independent careers in science by implementing Individual Development Plans (IDPs), individual postdoctoral mentoring committees, and customized opportunities for trainees to acquire experience in mentoring and teaching depending on their career goals. The CCBM Training Program will support 8 postdoctoral fellows per year for 2-year appointments. It will be administered by a Director (Dr. Thomas Roberts, Contact PD/PI) and a co-Director (Dr. Nika Danial, PD/PI), and will include 26 mentors and 6 co-mentors from 4 departments at DFCI. The program Director and co- Director will work closely with a Training Oversight Committee (TOC), an External Advisory Board (EAB), and a trainee-led advisory group consisting of current and past program fellows who will help identify ways to optimize the program. Additional strategies to measure trainee satisfaction, quantify outcomes, and evaluate the effectiveness of the program will include annual surveys from trainees and mentors, as well as exit and alumni interviews. Institutional support through state-of-the-art core facilities and technology platforms, as well as funds to support T32-specific training activities and yearly EAB meetings will significantly enhance the training program. In addition to offering robust training in a diverse range of scientific and career development skills, a key goal of the program is to recruit and support a more diverse group of trainees. To further ensure the program's effectiveness in enhancing diversity, our EAB and Training Oversight Committee include leaders with deep experience in diversity and inclusion. We believe the integrative CCBM Training Program will prepare fellows for a range of research careers and train the next generation of scientists who will thrive in the 21st century biomedical workforce that will make breakthroughs in cancer research and treatment. !

项目概要/摘要丹纳法伯癌症研究所 (DFCI) 的教员正在申请资金来支持一个新的、综合性的、癌症化学生物学和代谢（CCBM）博士后培训项目——两个协同和以小分子化学和生物化学为基础的概念上相关的研究学科从基础研究和转化研究的角度来看，该项目的重要性日益增加，该项目的目标是： 1) 提供与癌症化学生物学和代谢相关的广泛主题的培训，例如临床前癌症靶标验证、化学筛选、基于结构的药物发现、肿瘤代谢、肿瘤与宿主代谢之间的串扰、细胞生物能量学和代谢组学、机制生物化学、蛋白质组学和化学蛋白质组学以及动物肿瘤建模；2) 让学员熟悉状态- 化学生物学和代谢科学领域最先进的技术和方法，3）培训研究员识别重要的问题和方法将推动该领域向前发展并提供转化机会影响癌症治疗；4）为学员提供发展和提高资助能力的机会和科学沟通技巧；5）通过以下方式指导研究员走向独立的科学职业道路实施个人发展计划（IDP）、个人博士后指导委员会，以及为学员提供定制机会，根据他们的情况获得指导和教学经验职业目标。 CCBM 培训计划每年将支持 8 名博士后研究员，为期 2 年。由一名董事（Thomas Roberts 博士，联系人 PD/PI）和一名联合董事（Nika Danial 博士，PD/PI）管理，将包括来自 DFCI 4 个部门的 26 名导师和 6 名联合导师。总监将与培训监督委员会 (TOC)、外部顾问委员会 (EAB) 和由实习生领导的咨询小组由现任和过去的项目研究员组成，他们将帮助确定以下方法：优化计划的其他策略来衡量学员满意度、量化结果和评估该方案的有效性将包括对受训者和导师进行的年度调查以及退出和校友访谈。通过最先进的核心设施和技术平台提供机构支持。作为支持 T32 特定培训活动和年度 EAB 会议的资金将显着增强除了提供各种科学和职业发展方面的强有力的培训之外。技能，该计划的一个关键目标是招募和支持更加多样化的学员群体，以进一步确保。该计划在增强多样性方面的有效性，我们的 EAB 和培训监督委员会包括领导者我们相信，综合 CCBM 培训计划将在多元化和包容性方面拥有丰富的经验。为研究员做好各种研究职业的准备，并培训将在该领域蓬勃发展的下一代科学家 21世纪的生物医学劳动力将在癌症研究和治疗方面取得突破。！

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Target 2035 - update on the quest for a probe for every protein.

目标 2035 - 寻找每种蛋白质探针的最新进展。

DOI：
发表时间：
2022-01-27
期刊：
影响因子：
4.1
作者：
Müller, Susanne;Ackloo, Suzanne;Al Chawaf, Arij;Al;Antolin, Albert;Baell, Jonathan B;Beck, Hartmut;Beedie, Shaunna;Betz, Ulrich A K;Bezerra, Gustavo Arruda;Brennan, Paul E;Brown, David;Brown, Peter J;Bullock, Alex N;Carter
通讯作者：
Carter

Three-Component [3+2] Cycloaddition for Regio- and Diastereoselective Synthesis of Spirooxindole-Pyrrolidines.

用于螺吲哚-吡咯烷区域和非对映选择性合成的三组分[3 2]环加成。

DOI：
发表时间：
2022-02-28
期刊：
影响因子：
0
作者：
Zhang, Xiaofeng;Liu, Miao;Zhan, Desheng;Kaur, Manpreet;Jasinski, Jerry P;Zhang, Wei
通讯作者：
Zhang, Wei

Pseudo-Five-Component Reaction for Diastereoselective Synthesis of Butterfly Shaped Bispiro[Oxindole-Pyrrolidine]s.

用于非对映选择性合成蝴蝶形双螺[羟吲哚-吡咯烷]的伪五组分反应。

DOI：
10.1021/acs.joc.1c01797
发表时间：
2021-11-19
期刊：
The Journal of organic chemistry
影响因子：
0
作者：
Xiaofeng Zhang;W. Qiu;S. Murray;Desheng Zhan;Jason J Evans;J. Jasinski;Xiao Wang;Wei Zhang
通讯作者：
Wei Zhang

Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality.

靶向蛋白质降解作为研究工具和药理学方式的严格评估。