MI-SMART: Methods for Optimizing Multilevel Adaptive Implementation Strategies to Promote the Adoption of Effective SUD and HIV Services

MI-SMART：优化多级自适应实施策略以促进采用有效 SUD 和 HIV 服务的方法

• 批准号: 10640291
• 负责人: Daniel Almirall
• 金额: $ 37.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640291
• 关键词: Address; Adoption; Applet; Behavioral; Clinic; Code; Collaborations; Computer software; Data; Data Analyses; Death Rate; Development; Dose; Educational workshop; Electronic Health Record; Ensure; Evidence based practice; Experimental Designs; Feedback; Generations; Goals; Guidelines; HIV; Heterogeneity; Individual; Intervention; Methodology; Methods; Motivation; Opioid; Patients; Policies; Primary Care; Process; Publishing; Randomized; Risk; Sample Size; Scientist; Sequential Multiple Assignment Randomized Trial; Services; Speed; Substance Use Disorder; System; Techniques; Technology; Time; Training; Update; Urine; Work; Writing; design; drug testing; evidence base; implementation strategy; improved outcome; individualized prevention; non-cancer chronic pain; peer coaching; prescription opioid; prevention service; primary care patient; recovery services; service uptake; skills; substance use; theories; tool; treatment services; trial design; user friendly software; user-friendly; webinar

PROJECT SUMMARY: PROJECT 1 Evidence-based prevention, treatment, and recovery services for substance use disorders (SUDs) and HIV often fail to be implemented or sustained due to barriers at multiple levels, such as lack of time and skills at the practitioner level; lack of support or established processes at the clinic level; or lack of effective technological tools, financing, and policies at the system level. The long-term goal of this project is to develop a new generation of effective, replicable multi-level strategies for implementing evidence-based SUD/HIV services in real-world settings, thus improving the outcomes of individuals with or at risk for SUD or HIV. To achieve this long-term goal, we will: (Aim 1) Develop principles for the design of Multi-level Adaptive Implementation Strategies (MAISYs) to guide how best to adapt (e.g., augment, intensify) implementation strategies based on the context and needs at multiple levels (e.g., clinic, practitioner); and develop a new experimental design—the Multi-level Implementation Sequential, Multiple Assignment, Randomized Trial (MI-SMART), in which sequences of randomizations occur at multiple levels—to inform the construction of optimized MAISYs; (Aim 2) Develop new data analysis methods for use with longitudinal data in an MI-SMART to address a suite of questions about the construction of a MAISY; (Aim 3) Develop sample size calculators for MI-SMARTs to enable SUD/HIV implementation scientists to plan and calculate statistical power for different types of MI- SMART designs; and (Aim 4) Work with the Dissemination and Training Core to disseminate the developed methods so that they can be readily applied by SUD/HIV scientists. This includes the development of webinars, workshops, tutorials, and free, user-friendly software for SUD/HIV scientists.

项目摘要：项目1 基于证据的预防，治疗和恢复服务用于药物使用障碍（SUD）和HIV 由于障碍在多个层面上，通常无法实施或持续，例如缺乏时间和技能 从业者级别；在诊所一级缺乏支持或既定过程；或缺乏有效的技术 在系统层面上的工具，融资和政策。该项目的长期目标是开发新的 生成有效的，可复制的多层次策略，用于实施基于证据的SUD/HIV服务 现实世界中的环境，从而改善了患有SUD或HIV风险的人的结果。实现这一目标 长期目标，我们将：（目标1）制定设计多层次自适应实施的原则 策略（MAISYS）指导如何最好地适应（例如，增强，加强）实施策略 多个级别的上下文和需求（例如，诊所，从业人员）；并开发新的实验设计 - 多级实施顺序，多个分配，随机试验（MI-SMART），其中 随机序列的序列在多个层面上发生 - 告知了优化的Maisys的构建； （目标2） 开发新的数据分析方法，用于在Mi-Smart中与纵向数据一起使用，以解决 关于建造Maisy的问题； （AIM 3）开发Mi-Smarts的样本量计算器至 使SUD/HIV实施科学家能够计划和计算不同类型的MI-的统计能力 智能设计； （目标4）与传播和训练核心合作以传播发达的 方法，以便可以由SUD/HIV科学家轻松应用它们。这包括开发网络研讨会， 用于SUD/HIV科学家的讲习班，教程和免费用户友好的软件。