Low-level Exposure to Multiple Metals: Effects on Cognition and Behavior

低水平接触多种金属：对认知和行为的影响

基本信息

批准号：
9060932
负责人：
Katarzyna Kordas
金额：
$ 26.79万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9060932
关键词：
Accounting Adolescence Affect Aggressive behavior Arsenic Attention Attention deficit hyperactivity disorder Behavior Behavioral Biological Biological Markers Blood Blood specimen Body Burden Cadmium Child Child health care Childhood Cognition Cognitive Cognitive deficits Cohort Studies Communication Data Development Disease Enrollment Environment Environmental Exposure Evaluation Exposure to Frustration General Population Goals Hair Hazardous Waste Health Health Communication Human Hyperactive behavior Individual Knowledge Lead Life Link Longitudinal Studies Manganese Measures Memory Metal exposure Metals Mission National Institute of Environmental Health Sciences Neurocognitive Outcome Performance Policies Population Prevention strategy Problem behavior Process Public Health Public Health Practice Recommendation Reporting Research Risk Sampling Schools Severities Short-Term Memory Testing Time Uruguay Uruguayan Visuospatial Work Workload base behavioral construct behavioral outcome child protection cognitive development cognitive function cognitive task cohort design disability executive function fifth grade first grade follow-up improved innovation lead concentration lead exposure middle childhood neurobehavioral prevent relating to nervous system selective attention socioeconomics sound study population teacher third grade toxic metal toxicant trend

项目摘要

DESCRIPTION (provided by applicant): Worldwide, millions of children are exposed to toxic metals, including lead (Pb), arsenic (As), cadmium (Cd), and manganese (Mn), with important consequences for their health and development. Research findings confirm the association between exposure to single toxic metals and neurobehavioral deficits in children. However, metal exposures rarely occur in isolation. Nevertheless, few studies to date have examined interactions among toxic metals on cognitive deficits or behavioral problems, often with mixed results. There is also little under- standing of the long-term consequences of multiple metal exposures on child outcomes. Thus, the scarcity of data and methodological limitations have kept this field from making sound recommendations for the protection of children and pediatric practice. The long-term goal of this research is to understand how low-level exposure to multiple toxic metals affects neurobehavioral outcomes across childhood and adolescence, identifying potential synergistic effects of metals on children's outcomes. The objective of the proposed study is to determine how children's exposure to multiple metals affects specific cognitive functions and behavior through middle child- hood. The proposed study is a longitudinal cohort study that will take place in Montevideo, Uruguay and builds on previous research in 1st grade children. The study focuses on As, Cd, Mn, Pb because these occur at biologically relevant levels in the environment and biological samples collected from the Uruguayan children. The central hypothesis is that within low range of exposures, higher concentrations of As, Cd, Mn and Pb will be individually associated with poorer cognition and behavior over time, and that co-exposure to these metals will produce additive or multiplicative negative effects on neurobehavioral outcomes. The specific aims of this study are to: 1) describe the trends and variability of the long-term exposure to As, Cd, Mn and Pb, 2) characterize the extent to which body burden of the metals is associated with deficits in specific cognitive functions, and 3) characterize the extent to which the metals are associated with reported and observed problem behaviors. The study population will consist of ~760 children. The study has a staggered design, entailing: 1) the follow-up of children who had been evaluated as 1st-graders in 2 previous studies (years 2010-2013), and 2) the enrollment in 1st grade and follow-up of additional cohorts of children. Hair and blood samples will be collected yearly, and children's cognition and behavior will be evaluated in 1st, 3rd and 5th grade. This approach is innovative because, in contrast to previous studies, in employs a longitudinal approach to examine interactions among multiple metals that occur at low levels in the environment, and employs specific process-oriented cognitive outcomes as opposed to IQ, which is a summative measure. This research is significant in its contribution to the communication of health risks associated with exposure to multiple toxic metals, and in its potential contribution to approaches that will prevent or alleviate the developmental consequences of exposure.

描述（由申请人提供）：在全球范围内，数百万儿童暴露于有毒金属，包括铅（PB），砷（AS），镉（CD）和锰（MN），对他们的健康和发展产生了重要影响。研究发现证实了暴露于单一有毒金属的接触与儿童神经行为缺陷之间的关联。但是，金属暴露很少会孤立地发生。然而，迄今为止，很少有研究检查有毒金属在认知缺陷或行为问题上的相互作用，通常会出现不同的结果。多种金属暴露于儿童结局的长期后果也几乎没有理解。因此，数据和方法论上的局限性的稀缺使该领域无法为保护儿童和小儿实践提出明智的建议。这项研究的长期目标是了解低水平对多种有毒金属的接触如何影响整个儿童和青春期的神经行为结局，从而确定金属对儿童预后的潜在协同作用。拟议的研究的目的是确定儿童接触多种金属如何通过中间儿童影响特定的认知功能和行为。拟议的研究是一项纵向队列研究，该研究将在乌拉圭蒙得维的亚举行，并在一年级儿童的先前研究基础上进行。该研究重点关注AS，CD，MN，PB，因为这些发生在环境中的生物学水平和从乌拉圭儿童中收集的生物样品。中心假设是，在较低的暴露范围内，较高的AS，CD，MN和PB会单独与较差的认知和行为随着时间的推移而单独相关，并且对这些金属的共暴露会对神经行为的添加性或多重性负面影响。这项研究的具体目的是：1）描述长期暴露于AS，CD，MN和PB的趋势和可变性，2）表征金属的身体负担与特定认知功能的缺陷有关，以及3）表征金属与报告和观察到的问题相关的金属的程度。研究人群将由约760名儿童组成。这项研究的设计交错，需要：1）在先前的2项研究中被评估为一年级的儿童的随访（2010-2013年），以及2）1年级的入学率和其他儿童同伙的随访。头发和血液样本将每年收集，儿童的认知和行为将在一年级，三年级和5年级评估。这种方法具有创新性，因为与以前的研究相比，采用了一种纵向方法来检查在环境中低水平的多种金属之间的相互作用，并采用了特定的面向过程的认知结果，而不是智商，这是一种总结措施。这项研究对与暴露于多种有毒金属相关的健康风险的贡献以及其对方法的潜在贡献对可以防止或减轻暴露的发展后果的潜在贡献是重要的。