Binge Eating as a Mechanism Underlying the Food Insecurity-Obesity Paradox in Adolescents

暴饮暴食是青少年粮食不安全-肥胖悖论的潜在机制

• 批准号: 10583732
• 负责人: Vivienne M Hazzard
• 金额: $ 11.89万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583732
• 关键词: Accounting; Adolescence; Adolescent; Adolescent obesity; Adult; Affect; Area; Award; Behavior; Beverages; Binge Eating; Body mass index; Child; Data; Decision Trees; Development; Dietary Factors; Dietitian; Eating; Energy consumption; Etiology; Face; Feedback; Feeling; Food; Funding; General Population; Goals; Household; Intervention; Interview; Knowledge; Longitudinal Studies; Machine Learning; Mediating; Mediation; Mediator; Mental Health; Mentors; Mentorship; Methods; Minnesota; Morbidity - disease rate; Nutrient; Obesity; Outcome; Pathway interactions; Pattern; Phase; Premature Mortality; Prevalence; Public Health; Qualitative Research; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Schools; Statistical Methods; Statistical Models; Strategic Planning; Structure; Subgroup; Techniques; Testing; Time; Training; Trees; United States; United States National Institutes of Health; Universities; Weight; Weight Gain; Work; Youth; career; cohort; excessive weight gain; experience; food insecurity; food security; healthy weight; high body mass index; human centered design; improved; innovation; marginalized population; novel; obesity prevention; obesity risk; physical conditioning; population based; prevent; recruit; response; therapy design; therapy development; young adult

PROJECT SUMMARY/ABSTRACT Food insecurity is paradoxically associated with elevated risk of adolescent obesity in the United States. The mechanisms underlying this excess risk are not well understood, and such knowledge is essential for informing obesity prevention efforts for adolescents from under-resourced backgrounds. Thus, aligned with the need emphasized by the Strategic Plan for NIH Obesity Research to identify the reasons contributing to increased risk for obesity among economically marginalized populations, research is critically needed to elucidate modifiable mechanisms to target in obesity prevention efforts among food-insecure adolescents. In the proposed project, Dr. Hazzard, a registered dietitian and public health researcher, will examine binge eating as a potential mechanism to explain the association between food insecurity and elevated risk for adolescent obesity. With the exceptional mentorship team she has assembled and the resources available to her through the University of Minnesota, this Pathway to Independence Award will support Dr. Hazzard in filling critical training gaps and conducting the research necessary to launch her career as an independent investigator conducting intervention work to promote food security and healthy weight among adolescents experiencing food insecurity. To prepare her for this role, a multifaceted training plan including coursework, mentorship, and research is proposed in: (1) qualitative and mixed methods, (2) advanced statistical methods, with a focus on machine learning and causal mediation analysis, and (3) intervention design, development, and dissemination, with an emphasis on human- centered design. The expertise Dr. Hazzard develops through this training plan will be essential for conducting the proposed research. During the mentored K99 phase, she will elucidate the etiology of binge eating in the context of food insecurity during adolescence using a mixed-methods approach that involves (a) conducting qualitative interviews in food-insecure adolescents who report binge eating and (b) leveraging existing data from an NIH-funded observational cohort to employ tree-based machine learning techniques (Aim 1). In the independent R00 phase, Dr. Hazzard will recruit 175 adolescents into a new, independent cohort that she will follow for 18 months to quantify the extent to which binge eating mediates the longitudinal association between food insecurity and weight gain during adolescence (Aim 2). Finally, using a human-centered design approach, she will develop vignettes describing potential school-based interventions to improve food security and prevent excess weight gain among food-insecure adolescents and assess perceived acceptability of the potential interventions using these vignettes in semi-structured interviews with adolescents who have experienced food insecurity (Aim 3). Findings from this project will lay the groundwork for the development and implementation of a school-based intervention to promote food security and healthy weight among adolescents experiencing food insecurity and, in turn, promote Dr. Hazzard’s successful transition to an independent research career. 1

项目摘要/摘要 粮食不安全与美国青少年肥胖风险升高相关。这 这种超出风险的机制尚不清楚，这种知识对于告知信息至关重要 从资源不足的背景下为青少年的肥胖预防工作。那与需求保持一致 NIH肥胖研究的战略计划强调，以确定导致风险增加的原因 对于经济边缘化人群中的肥胖症，需要进行迫切需要研究以阐明可修改 靶向肥胖预防努力的机制。在拟议的项目中 注册营养师和公共卫生研究人员Hazzard博士将研究暴饮暴食是一种潜力 解释粮食不安全与青少年肥胖风险升高之间的关联的机制。与 她已经组装了出色的精明团队，以及通过大学提供的资源 明尼苏达州，这一获得独立奖的奖项将支持Hazzard博士填补关键的培训空白和 进行必要的研究，以启动她作为独立调查员进行干预的职业生涯 努力促进饮食不安全感的青少年中的粮食安全和健康体重。准备 她担任这个角色，一项多方面的培训计划，包括课程，精神训练和研究。 定性和混合方法，（2）高级统计方法，重点是机器学习和因果关系 调解分析以及（3）干预设计，开发和传播，重点是人类 中心设计。 Hazzard博士通过该培训计划发展的专业知识对于进行 拟议的研究。在修改K99阶段，她将阐明在 青少年期间食物不安全感的背景使用混合方法方法，涉及（a）进行（a） 报告Benge饮食和（b）从 基于员工树的机器学习技术的NIH资助的观察队列（AIM 1）。在 独立R00阶段，Hazzard博士将招募175名青少年，成为一个新的独立队列 遵循18个月以量化暴饮暴食的程度 青少年期间的粮食不安全和体重增加（AIM 2）。最后，使用以人为本的设计方法， 她将开发描述潜在基于学校的干预措施以改善粮食安全并防止 食物不安全的青少年体重增加过多，并评估潜在的可接受性 在半结构化的访谈中，使用这些体验的青少年进行干预措施 不安全感（目标3）。该项目的调查结果将为开发和实施奠定基础 一项基于学校的干预措施，以促进粮食的青少年中的粮食安全和健康体重 不安全感，反过来促进了Hazzard博士的成功过渡到独立研究职业。 1