Is Low-Level Arsenic Exposure Related to Neurobehavioral Deficits in Children

低水平砷暴露与儿童神经行为缺陷有关吗

基本信息

批准号：
8415963
负责人：
Katarzyna Kordas
金额：
$ 16.19万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8415963
关键词：
7 year old Accounting Address Adolescence Affect Age Archives Area Arsenic Behavior Behavioral Cacodylic Acid Categories Child Childhood Chronic Cognition Cognitive Cognitive deficits Cohort Studies Collection Data Development Disease Enrollment Environment Environmental Exposure Environmental Risk Factor Epidemiologic Studies Europe Excretory function Exposure to Folate Future Genes Genetic Genetic Polymorphism Goals Hair Health Communication Human Human body Impaired cognition Impairment Individual Integration Host Factors Intervention Investigation Knowledge Life Measures Methylation Mexico Mission Modification Monitor National Institute of Environmental Health Sciences Neurotoxins Nutritional Nutritional status Outcome Performance Persons Play Policies Population Prevention Prevention strategy Problem behavior Process Public Health Research Risk Risk Assessment Role Sampling Schools Source Testing United States Urine Uruguay Water Work base behavioral impairment cognitive function design disability drinking water experience first grade innovation monomethylarsonic acid neurobehavioral neurotoxic premature sex sound urinary ward

项目摘要

DESCRIPTION (provided by applicant): Millions of children worldwide are exposed to neurotoxic substances in their environment, such as arsenic, that produce potentially irreversible intellectual and behavioral impairments. Cognitive deficits, most typically measured as IQ in school children living in high-exposure areas, have been associated with higher concentrations of arsenic in drinking water, urine and hair. However, we have limited understanding of the extent to which low- level arsenic exposure is associated with children's cognitive function and behavior. This gap in knowledge limits accurate risk assessment and the communication of health risks associated with arsenic exposure. The long-term goal is to understand how low-level arsenic exposure affects neurobehavioral outcomes across childhood and adolescence, and to identify host and environmental factors (such as age, sex, genetic make- up, nutritional status, and other environmental exposures) that may modify the effects of arsenic on child cognition and behavior. The objective of the proposed study is to determine the effects of low-level arsenic exposure and arsenic methylation capacity on cognitive function and behavior in 6-7 year-old children. The central hypothesis is that within low-range of exposures, higher arsenic concentrations in water and urine (particularly higher fraction of urinary methylarsonic acid) will be associated with poorer cognition and behavior problems. The two specific aims are 1) Determine to what extent low-level arsenic exposure (<50 5g/L) is associated with neurobehavioral outcomes in first-grade children, and 2) Determine to what extent low arsenic methylation capacity impairs cognition and behavior in first-grade children exposed to As. Archived water and urine samples from an ongoing study of first-graders from Montevideo, Uruguay will be utilized to address both aims, in addition to the collection of water and urine samples from newly enrolled children. Results from extensive Neurobehavioral assessments of the children and indicators of nutritional status and neurotoxicant exposure will be employed. This approach is innovative because in contrast to previous studies, it systematically examines the effects of low-level arsenic exposure and methylation capacity on child cognition. These methodological advances will result in more accurate risk-assessment of arsenic exposure on its own and provide important data to inform the design of large, systematic investigations of these issues in the future. This research is significant in its contribution to the communication of health risks associated with arsenic exposure. Important strides toward the prevention of exposure and the development of risk-modification strategies can also be achieved once factors associated with the excretion of arsenic (methylation) are identified. Finally, the significance of this research, over the long-term, lies in its potential contribution to policies on arsenic monitoring and action levels in settings, such as the United States, where children typically experience low-level arsenic exposure.

描述（由申请人提供）：全球数百万儿童在其环境中暴露于砷中的神经毒性物质，这些物质会产生潜在的不可逆转的智力和行为障碍。认知缺陷最常见于居住在高曝光地区的小学生中的智商，与饮用水，尿液和头发的砷浓度更高有关。但是，我们对低水平的砷暴露与儿童的认知功能和行为有关的程度有限。知识方面的差距限制了准确的风险评估以及与砷暴露有关的健康风险的交流。长期目标是了解低水平的砷暴露能够影响整个儿童和青春期的神经行为结局，并确定可能改变砷对儿童认知和行为的影响的宿主和环境因素（例如年龄，性别，性别，遗传化妆，营养状况以及其他环境暴露）。拟议的研究的目的是确定低水平砷暴露和砷甲基化能力对6-7岁儿童认知功能和行为的影响。中心假设是，在低范围内，水和尿液中较高的砷浓度（尤其是尿甲基甲基酸的较高部分）将与认知和行为问题较差有关。这两个具体目的是1）确定低水平的砷暴露（<50 5g/l）与一年级儿童的神经行为结局有关，而2）确定在多大程度上，低砷甲基化能力会在多大程度上损害了一年级儿童的认知和行为。除了收集新入学的儿童的水和尿液样本外，还将利用对乌拉圭蒙得维的亚的一年级研究的归档水和尿液样品来解决这两个目标。来自广泛的结果对儿童的神经行为评估以及营养状况和神经毒性暴露的指标。这种方法具有创新性，因为与以前的研究相反，它系统地研究了低水平的砷暴露和甲基化能力对儿童认知的影响。这些方法上的进步将使对砷暴露的风险评估更加准确，并提供重要的数据，以告知对这些问题的大型系统调查的设计。这项研究对与砷暴露相关的健康风险的交流贡献很重要。一旦确定了与砷的排泄（甲基化）相关的因素，也可以实现朝着预防暴露和发展风险调整策略发展的重要步伐。最后，这项研究的重要性在长期的范围内，其潜在的对砷监测和行动水平的政策的潜在贡献，例如美国，在美国，儿童通常会经历低级砷的暴露。