Nutritional and Heavy Metals: Effects on Child Learning and Behavior in Uruguay

营养和重金属：对乌拉圭儿童学习和行为的影响

基本信息

批准号：
7688657
负责人：
Katarzyna Kordas
金额：
$ 12.49万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-17 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7688657
关键词：
7 year old Address Affect Age Anemia Area Arsenic Behavior Behavior Disorders Behavioral Biometry Child Childhood Clinic Cognition Cognitive Collaborations Collection Communities Complex Country Data Developed Countries Developing Countries Development Developmental Disabilities Diagnosis Economics Environmental Epidemiology Environmental Exposure Environmental Pollution Epidemiologic Studies Epidemiology Future Goals Growth Heavy Metals Hospitals Human Resources Income Infant Institution Investigation Iron Lead Learning Learning Disabilities Malnutrition Manganese Mercury Metal exposure Nature Needs Assessment Neurocognitive Neurodevelopmental Disability Nutritional Nutritionist Performance Prevalence Process Psychologist Public Health Public Health Schools Research Research Design Research Infrastructure Resources Risk Factors School-Age Population Schools Screening procedure Severities Time Toxic Environmental Substances Toxic effect Toxicant exposure Toxin Trace metal Training Universities Uruguay Woman aged base design epidemiology study forging lead exposure modifiable risk pediatrician prevent psychosocial public health relevance social stressor toxicant

项目摘要

DESCRIPTION (provided by applicant): Neurodevelopmental disabilities in children from low-to-middle income countries produce a substantial negative impact on societal and economic growth. Many of the causes of developmental disabilities, such as environmental toxins, nutritional deficiencies, psychosocial stressors, are common in resource-poor countries. Young children are particularly vulnerable to environmental exposures because rapid development creates windows of opportunity for toxins to exert their effects. In areas of the world where little research on neurodevelopmental disabilities has been conducted, it is necessary to assess the prevalence and nature of cognitive and behavioral deficits. In Montevideo, Uruguay, there is evidence that children are exposed to multiple heavy metals. However, to date very little research exists in this unique setting to understand the effects of multiple metal exposures on cognition, behavior, and school performance of urban children. There is also no research on how these exposures could be prevented or mitigated. We propose to conduct an investigation of cognitive performance and behavior in 200 children aged 6-7 years from Montevideo, Uruguay. Early school age is a period of important intellectual and social growth, and it sets up children's scholastic trajectories. At this time, learning disabilities often become manifested and diagnosed in children. It is also an age when environmental insults are clearly manifested. The goal of this project is to build research capacity and infrastructure in environmental epidemiology. Also, it is to investigate the relationship between heavy metal exposures (lead, arsenic, mercury), trace metals (iron and manganese) and cognition, behavior, and school performance in children from Montevideo, Uruguay. In the process of collecting data, we will identify key steps in the research process that will require additional training or resources. PUBLIC HEALTH RELEVANCE: Neurodevelopmental disabilities in children from low-to-middle income countries produce a substantial negative impact on societal and economic growth. Many of the causes of developmental disabilities, such as environmental toxins and nutritional deficiencies are common in resource-poor countries. We will conduct an investigation of cognitive performance and behavior in 200 children aged 6-7 years from Montevideo, Uruguay to understand the complex relationship between heavy metal exposures (lead, arsenic, mercury), trace metals (iron and manganese), and cognition, behavior, and school performance in children.

描述（由申请人提供）：中低收入国家儿童的神经发育障碍对社会和经济增长产生重大负面影响。造成发育障碍的许多原因，例如环境毒素、营养缺乏、社会心理压力源，在资源匮乏的国家很常见。幼儿特别容易受到环境暴露的影响，因为快速发育为毒素发挥作用创造了机会。在世界上很少对神经发育障碍进行研究的地区，有必要评估认知和行为缺陷的患病率和性质。在乌拉圭蒙得维的亚，有证据表明儿童接触多种重金属。然而，迄今为止，在这种独特的环境中，很少有研究来了解多种金属暴露对城市儿童认知、行为和学校表现的影响。也没有关于如何预防或减轻这些暴露的研究。我们计划对乌拉圭蒙得维的亚 200 名 6-7 岁儿童的认知表现和行为进行调查。学龄初期是智力和社会性成长的重要时期，它设定了儿童的学业轨迹。此时，学习障碍常常在儿童中表现出来并被诊断出来。这也是一个环境侵害明显显现的时代。该项目的目标是建设环境流行病学的研究能力和基础设施。此外，它还调查了乌拉圭蒙得维的亚儿童的重金属暴露（铅、砷、汞）、微量金属（铁和锰）与认知、行为和学校表现之间的关系。在收集数据的过程中，我们将确定研究过程中需要额外培训或资源的关键步骤。公共卫生相关性：中低收入国家儿童的神经发育障碍对社会和经济增长产生重大负面影响。造成发育障碍的许多原因，例如环境毒素和营养缺乏，在资源匮乏的国家很常见。我们将对乌拉圭蒙得维的亚 200 名 6-7 岁儿童的认知表现和行为进行调查，以了解重金属暴露（铅、砷、汞）、微量金属（铁和锰）与认知之间的复杂关系，儿童的行为和学校表现。

项目成果

期刊论文数量（21）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Nutritional status and diet as predictors of children's lead concentrations in blood and urine.

DOI：
10.1016/j.envint.2017.11.013
发表时间：
2018-03
期刊：
Environment international
影响因子：
11.8
作者：
Kordas K;Burganowski R;Roy A;Peregalli F;Baccino V;Barcia E;Mangieri S;Ocampo V;Mañay N;Martínez G;Vahter M;Queirolo EI
通讯作者：
Queirolo EI

Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children.

乌拉圭学童的多种金属暴露、饮食和氧化应激。

DOI：
10.1016/j.envres.2018.06.028
发表时间：
2018
期刊：
Environmental research
影响因子：
8.3
作者：
Kordas,Katarzyna;Roy,Aditi;Vahter,Marie;Ravenscroft,Julia;Mañay,Nelly;Peregalli,Fabiana;Martínez,Gabriela;Queirolo,ElenaI
通讯作者：
Queirolo,ElenaI

A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate.