Maintenance of Ideal Cardiovascular Health across the Life Course in Women

维持女性整个生命过程中理想的心血管健康

基本信息

批准号：
9144826
负责人：
Holly Catherine Gooding
金额：
$ 17.02万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9144826
关键词：
21 year old Address Adolescence Adolescent Adolescent and Young Adult Adult Age American Area Atherosclerosis Awareness Behavior Behavior Therapy Behavioral Biological Preservation Blood Pressure Boston Cardiovascular Diseases Cardiovascular system Cause of Death Child health care Childhood Cholesterol Chronic Disease Clinical Cognitive Cohort Analysis Cohort Studies Communication Research Coronary artery Coupled Data Data Analyses Deterioration Development Diabetes Mellitus Education Environment Epidemiologic Studies Epidemiology Ethnic group Female Female Adolescents Focus Groups Future Glucose Goals Growth Guidelines Health Health Care Costs Health Communication Health Promotion Individual Intervention K-Series Research Career Programs Lead Life Life Cycle Stages Life Expectancy Longevity Longitudinal Studies Maintenance Measures Mentors Mentorship Methodology Methods Modeling Morbidity - disease rate National Heart, Lung, and Blood Institute Patients Pattern Pediatric Hospitals Physiological Predisposition Probability Psychological Factors Public Health Practice Public Health Schools Qualitative Methods Qualitative Research Race Research Research Personnel Research Training Risk Schools Staging Statistical Methods Techniques Testing Training Training Activity Translating United States Vulnerable Populations Woman Writing Youth adolescent health biopsychosocial cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health career career development catalyst cohort design early adolescence early childhood effective intervention experience girls innovation meetings middle age mortality non-invasive imaging novel novel strategies patient oriented patient oriented research predictive modeling primary outcome racial and ethnic secondary outcome young adult young woman

项目摘要

DESCRIPTION (provided by applicant): This patient-oriented K23 Career Development Award will provide the candidate with the training and research experience essential to launch an independent research career focused on the early prevention of cardiovascular disease in girls and women. Recent research has identified substantially lower cardiovascular morbidity and mortality in those women able to reach middle age with a constellation of physiologic and behavioral factors known as ideal cardiovascular health. However, little is known about earlier factors that are particularly salient for the maintenance of ideal cardiovascular health into adulthood in general or in women specifically. By using a novel technique of creating sequential risk prediction models in two epidemiologic cohorts with overlapping age ranges, the candidate will quantify the relative importance of cardiovascular health-promoting behavioral, physiologic, and psychological factors during the critical life stages of adolescence and early young adulthood. [The candidate will conduct qualitative studies to identify developmentally appropriate strategies for promotion of behaviors identified in the two cohort studies. The candidate will then be poised to write an R01 application focused on developing and evaluating targeted behavioral interventions for promoting ideal health among adolescent and young adult women from a variety of racial/ethnic backgrounds.] The training plan will support all aspects of the research strategy and uniquely prepare the candidate for an independent research career using longitudinal cohort analyses and qualitative research strategies to inform cutting edge patient-oriented behavioral interventions. The coursework, mentorship team, and research experiences are designed to provide synergistic training in 1) life course and chronic disease epidemiology, 2) statistical methods for studying critical windows in the life course, and 3) [patient-oriented health communications research that informs the design of developmentally appropriate behavioral interventions]. The Harvard School of Public Health, Harvard Graduate School of Education, Harvard Catalyst, and Boston Children's Hospital all offer unparalleled environments in these three areas. The candidate has assembled a mentorship team with expertise in cardiovascular epidemiology, child and adolescent health, longitudinal cohort analysis, focus group methodology, qualitative data analysis, and health communication and health promotion with vulnerable populations. Mentored by this team the candidate will be well-suited to achieve her immediate career goals of furthering her training in patient-oriented research and cardiovascular epidemiology, identifying critical windows in the lives of young women for cardiovascular health maintenance, and translating these findings to cardiovascular health promoting strategies in youth. [Training activities and results will inform submission of R01 proposals to conduct trials of behavioral interventions aimed at the unique needs of adolescent girls and young women and to conduct epidemiologic studies of cardiovascular health promoting factors in early childhood and the peri-natal period.] Ultimately the candidate's goals are to deepen the understanding of factors related to the maintenance of cardiovascular health throughout the life course and to design novel and effective interventions that enhance positive factors and counterbalance negative factors related to cardiovascular disease risk.

描述（由申请人提供）：这个以患者为导向的 K23 职业发展奖将为候选人提供开展独立研究职业所必需的培训和研究经验，该职业专注于女孩和妇女心血管疾病的早期预防。那些能够达到中年且拥有一系列被称为理想心血管健康的生理和行为因素的女性，其心血管发病率和死亡率较低。然而，人们对通常在成年期维持理想心血管健康特别重要的早期因素知之甚少。或在通过使用一种新技术，在两个年龄范围重叠的流行病学队列中创建序贯风险预测模型，候选人将量化青春期和青春期关键生命阶段促进心血管健康的行为、生理和心理因素的相对重要性。 [候选人将进行定性研究，以确定促进两项队列研究中确定的行为的适合发展的策略，然后候选人将准备编写一份 R01 申请，重点是开发和评估有针对性的行为干预措施，以促进理想的健康。在青少年和来自不同种族/民族背景的年轻成年女性。] 培训计划将支持研究策略的各个方面，并利用纵向队列分析和定性研究策略为候选人提供独特的独立研究职业准备，以告知最先进的以患者为导向的行为课程作业、指导团队和研究经验旨在提供以下方面的协同培训：1) 生命历程和慢性病流行病学，2) 研究生命历程关键窗口的统计方法，以及 3) [以患者为导向的健康传播研究]。通知设计适合发展的行为干预措施]。哈佛大学公共卫生学院、哈佛大学教育研究生院、哈佛催化剂和波士顿儿童医院在这三个领域都提供了无与伦比的环境，他们在心血管流行病学、在该团队的指导下，候选人将非常适合实现其进一步培训的近期职业目标。以患者为导向的研究和心血管流行病学，确定年轻女性生活中维持心血管健康的关键窗口，并将这些发现转化为青年心血管健康促进策略[培训活动和结果将为提交进行行为试验的 R01 提案提供信息。针对青春期女孩和年轻妇女的独特需求的运动，并对幼儿期和围产期心血管健康促进因素进行流行病学研究。]最终候选人的目标是加深对与维持心血管健康相关的因素的理解一生健康课程并设计新颖有效的干预措施，增强与心血管疾病风险相关的积极因素并抵消消极因素。