Maintenance of Ideal Cardiovascular Health across the Life Course in Women

维持女性整个生命过程中理想的心血管健康

基本信息

批准号：
9925981
负责人：
Holly Catherine Gooding
金额：
$ 16.85万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9925981
关键词：
21 year old Address Adolescence Adolescent Adolescent and Young Adult Adult Age American Area Atherosclerosis Awareness Behavior Behavior Therapy Behavioral Behavioral trial Blood Pressure Boston Cardiovascular Diseases Cardiovascular system Cause of Death Child Health Childhood Cholesterol Chronic Disease Clinical Cognitive Cohort Analysis Cohort Studies Communication Research Coronary Artery Risk Development in Young Adults Study Coupled Data Data Analyses Deterioration Development Diabetes Mellitus Education Environment Epidemiology Ethnic group Female Female Adolescents Focus Groups Future Glucose Goals Growth Guidelines Health Health Care Costs Health Communication Health Promotion Individual Intervention K-Series Research Career Programs Lead Life Life Cycle Stages Life Expectancy Longevity Longitudinal Studies Longitudinal cohort Maintenance Measures Mentors Mentorship Methodology Methods Modeling Morbidity - disease rate National Heart, Lung, and Blood Institute Patients Pattern Pediatric Hospitals Physiological Predisposition Probability Psychological Factors Public Health Practice Public Health Schools Qualitative Methods Qualitative Research Race Research Research Personnel Risk Risk Factors Schools Statistical Methods Techniques Testing Training Training Activity Translating United States Vulnerable Populations Woman Writing Youth adolescent health biopsychosocial cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health career career development catalyst cohort design early adolescence early childhood effective intervention epidemiology study experience girls innovation meetings middle age mortality non-invasive imaging novel novel strategies patient engagement patient oriented patient oriented research perinatal period physiologic model preadolescence preservation primary outcome public health relevance racial and ethnic risk prediction model secondary outcome virtual young adult young woman

项目摘要

DESCRIPTION (provided by applicant): This patient-oriented K23 Career Development Award will provide the candidate with the training and research experience essential to launch an independent research career focused on the early prevention of cardiovascular disease in girls and women. Recent research has identified substantially lower cardiovascular morbidity and mortality in those women able to reach middle age with a constellation of physiologic and behavioral factors known as ideal cardiovascular health. However, little is known about earlier factors that are particularly salient for the maintenance of ideal cardiovascular health into adulthood in general or in women specifically. By using a novel technique of creating sequential risk prediction models in two epidemiologic cohorts with overlapping age ranges, the candidate will quantify the relative importance of cardiovascular health-promoting behavioral, physiologic, and psychological factors during the critical life stages of adolescence and early young adulthood. [The candidate will conduct qualitative studies to identify developmentally appropriate strategies for promotion of behaviors identified in the two cohort studies. The candidate will then be poised to write an R01 application focused on developing and evaluating targeted behavioral interventions for promoting ideal health among adolescent and young adult women from a variety of racial/ethnic backgrounds.] The training plan will support all aspects of the research strategy and uniquely prepare the candidate for an independent research career using longitudinal cohort analyses and qualitative research strategies to inform cutting edge patient-oriented behavioral interventions. The coursework, mentorship team, and research experiences are designed to provide synergistic training in 1) life course and chronic disease epidemiology, 2) statistical methods for studying critical windows in the life course, and 3) [patient-oriented health communications research that informs the design of developmentally appropriate behavioral interventions]. The Harvard School of Public Health, Harvard Graduate School of Education, Harvard Catalyst, and Boston Children's Hospital all offer unparalleled environments in these three areas. The candidate has assembled a mentorship team with expertise in cardiovascular epidemiology, child and adolescent health, longitudinal cohort analysis, focus group methodology, qualitative data analysis, and health communication and health promotion with vulnerable populations. Mentored by this team the candidate will be well-suited to achieve her immediate career goals of furthering her training in patient-oriented research and cardiovascular epidemiology, identifying critical windows in the lives of young women for cardiovascular health maintenance, and translating these findings to cardiovascular health promoting strategies in youth. [Training activities and results will inform submission of R01 proposals to conduct trials of behavioral interventions aimed at the unique needs of adolescent girls and young women and to conduct epidemiologic studies of cardiovascular health promoting factors in early childhood and the peri-natal period.] Ultimately the candidate's goals are to deepen the understanding of factors related to the maintenance of cardiovascular health throughout the life course and to design novel and effective interventions that enhance positive factors and counterbalance negative factors related to cardiovascular disease risk.

描述（由申请人提供）：这一面向患者的K23职业发展奖将为候选人提供培训和研究经验，这是启动独立研究职业至关重要的，该研究专注于早期预防女孩和女性心血管疾病。最近的研究已经确定那些能够达到中年的女性的心血管发病率和死亡率较低，其生理和行为因素被称为理想心血管健康。但是，对于早期的因素而言，对维持理想的心血管健康至少成年或专门为女性而言特别重要的因素知之甚少。通过使用一种新的技术，该技术在两个流行病学人群中创建顺序风险预测模型具有重叠的年龄范围，候选人将量化在青春期和年轻成年早期的关键生活阶段期间心血管健康行为，生理和心理因素的相对重要性。 [候选人将进行定性研究，以确定在两项队列研究中确定的行为的发展上适当的策略。然后，候选人将准备编写R01申请，重点是开发和评估有针对性的行为干预措施，以促进来自各种种族/种族背景的青少年和年轻妇女的理想健康。]培训计划将支持研究策略的所有方面并使用纵向队列分析和定性研究策略为候选人提供独特的候选人，以告知尖端面向患者的行为干预措施。课程工作，指导团队和研究经验旨在在1）生活课程和慢性病流行病学中提供协同培训，2）用于研究生活课程中关键窗口的统计方法，以及3）[面向患者的健康通信研究设计适当的行为干预措施的设计]。哈佛大学公共卫生学院，哈佛大学教育学院，哈佛大学催化剂和波士顿儿童医院都在这三个领域提供了无与伦比的环境。该候选人已经组建了一个指导团队，该团队在心血管流行病学，儿童和青少年健康，纵向队列分析，焦点小组方法论，定性数据分析以及健康沟通和健康促进方面具有专业知识。由这个团队的指导，候选人将非常适合实现她在以患者为导向的研究和心血管流行病学方面培训她的近期职业目标，确定了年轻女性在心血管健康维持的生活中的关键窗口，并将这些发现转化为心血管血管内的发现。健康促进青年的策略。 [培训活动和结果将为R01提案提交，以进行针对青少年女孩和年轻妇女独特需求的行为干预措施的试验，并在幼儿期和生日期间对心血管健康促进因素进行流行病学研究。]最终。]候选人的目标是加深对与心血管健康有关的因素的理解，并设计新颖有效的干预措施，以增强与心血管疾病风险相关的积极因素和平衡负面因素。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Adolescent and Young Adult Use of Social Media for Health and Its Implications.

DOI：
10.1016/j.jadohealth.2016.12.025
发表时间：
2017-06
期刊：
The Journal of adolescent health : official publication of the Society for Adolescent Medicine
影响因子：
0
作者：
Hausmann JS;Touloumtzis C;White MT;Colbert JA;Gooding HC
通讯作者：
Gooding HC

Improving Cardiovascular Health in a Pediatric Preventive Cardiology Practice.

在儿科预防心脏病学实践中改善心血管健康。

DOI：
10.1016/j.jpeds.2021.01.070
发表时间：
2021
期刊：
The Journal of pediatrics
影响因子：
0
作者：
Gooding,HollyC;Gauvreau,Kimberlee;Bachman,Jennifer;Baker,Annette;Griggs,SSkylar;Hartz,Jacob;Huang,Yisong;Mendelson,MichaelM;Palfrey,Hannah;deFerranti,SarahD
通讯作者：
deFerranti,SarahD

Staying Young at Heart: Cardiovascular Disease Prevention in Adolescents and Young Adults.